FlyBase Allele Report: Dmel\norpA[EE5]

General Information

Symbol

Dmel\norpA^EE5

Species

D. melanogaster

Name

FlyBase ID

FBal0013100

Feature type

allele

Associated gene

Dmel\norpA

Associated Insertion(s)

Carried in Construct

Also Known As

norpA⁷

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Yoshioka et al., 1985)

Mutagen

ethyl methanesulfonate

(Inoue et al., 1989)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of retinal degeneration

CEA

(Kinser and Dolph, 2012)

model of retinal disease

CEA

(Chinchore et al., 2012, Orem et al., 2006)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of retinal degeneration

is ameliorated by CtsL1^llcnbw38

(Kinser and Dolph, 2012)

is exacerbated by CtsL1^EY05806

(Kinser and Dolph, 2012)

model of retinal disease

is ameliorated by AP-2α⁰⁶⁶⁹⁴

(Orem et al., 2006)

is ameliorated by Arr2^K391A

(Orem et al., 2006)

is ameliorated by Arr2^R393A

(Orem et al., 2006)

is ameliorated by BacA\p35^GMR.PH

(Chinchore et al., 2012)

is ameliorated by Dredd^B118

(Chinchore et al., 2012)

is ameliorated by Rel^E20

(Chinchore et al., 2012)

is ameliorated by Rel^E38

(Chinchore et al., 2012)

is ameliorated by key¹

(Chinchore et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye

(Kinser and Dolph, 2012, Alloway et al., 2000)

eye photoreceptor cell

(LaLonde et al., 2005)

eye photoreceptor cell | conditional | somatic clone

(Orem et al., 2006)

ocellus

(Stark et al., 1989)

ocellus rhabdomere

(Stark et al., 1989)

ommatidium

(Kinser and Dolph, 2012, LaLonde et al., 2005)

ommatidium | progressive | conditional

(Chinchore et al., 2012)

photoreceptor neuron

(Inoue et al., 1989)

retina

(LaLonde et al., 2005, Lee et al., 2003, Alloway et al., 2000)

retina | conditional | somatic clone

(Orem et al., 2006)

retina | progressive | conditional

(Chinchore et al., 2012)

rhabdomere

(Kinser and Dolph, 2012)

rhabdomere | conditional | somatic clone

(Orem et al., 2006)

rhabdomere | progressive | conditional

(Chinchore et al., 2012)

rhabdomere R1

(Alloway et al., 2000)

rhabdomere R2

(Alloway et al., 2000)

rhabdomere R3

(Alloway et al., 2000)

rhabdomere R4

(Alloway et al., 2000)

rhabdomere R5

(Alloway et al., 2000)

rhabdomere R6

(Alloway et al., 2000)

Detailed Description

Statement

Reference

norpA⁷ mutants have no visual transduction in 90% of photoreceptor cells.

(Chaturvedi et al., 2014)

norpA⁷ mutant flies on 4 days of light exposure show retinal degeneration and loss of some photoreceptors; by 7 days of exposure they have undergone complete retinal degeneration with loss of most of the photoreceptors. No retinal degeneration is seen in dark-raised flies as compared to the WT control.

(Chinchore et al., 2012)

norpA⁷ mutants exposed to six days constant light display retinal degeneration. This degeneration is characterised by a decrease in rhabdomeres and disorganisation of the ommatidial array. Exposure to eight days of constant light leads to a complete loss of rhabdomeres.

After 4 weeks of constant light, norpA⁷ flies begin to exhibit signs of retinal degeneration. There is a decrease in the number of rhabdomeres with approximately 5 remaining per ommatidium. The rhabdomeres that remain are shrunken and exhibit vacuolization.

(Kinser and Dolph, 2012)

Mutant flies do not show defects in auditory responses, as measured by the sound-evoked compound action potentials in the antennal nerve and the displacement response of the antenna over a range of sound particle velocities.

(Senthilan et al., 2012)

norpA⁷ flies show a normal lifespan on dead yeast medium, but show reduced survival compared to controls on live yeast medium. The gut cells of the mutant flies fed on live yeast medium show severe apoptosis (the gut cells of mutant flies fed on dead yeast medium do not show severe apoptosis).

norpA⁷ flies show a 100-fold increase in the number of yeast colony-forming units (CFUs) in the gut compared to control flies when fed on live yeast medium.

(Ha et al., 2009)

norpA⁷ mutants exhibit greatly reduced thermotactic behaviour, losing the 18[o]C versus 24[o]C preference found in wild-type.

(Kwon et al., 2008)

Mutant flies maintain a high level of activity in an open field arena over the full 10-minute assay (wild-type flies show a decay in locomotor activity over time in this assay).

(Liu et al., 2007)

norpA⁷ somatic mutant eye clones from animals raised in the dark and then exposed to 5 days of constant room light show massive retinal degeneration. These mutants exhibit loss of ommatidial organisation, and shrinking or disappearance of most of the rhabdomeres.

(Orem et al., 2006)

Electroretinograms show that, in contrast to controls, a light-stimulated change in the membrane potential of retinal photoreceptors is not observed in norpA⁷ flies.

By 21 days after eclosion, norpA⁷ flies display light-dependent retinal degeneration, characterized by irregularly shaped ommatidia with intracellular vacuoles and the loss of multiple photoreceptor cells.

Retinas from norpA⁷ mutant flies raised under continuous light conditions show no apparent retinal degeneration after 1 day, though degeneration (smaller rhabdomeres, some vacuolation) is evident by 6 days after eclosion.

(LaLonde et al., 2005)

norpA⁷ animals do not have a deep pseudopupil after 10 days in a normal light/dark cycle, indicating light-dependent retinal degeneration.

(Lee et al., 2003)

norpA⁷ animals have a normal heartbeat and response to serotonin or norepinephrine is normal.

(Johnson et al., 2002)

After 6 days of exposure to continuous room light, norpA⁷ mutants exhibit a light dependant retinal degeneration phenotype. This is characterised by the phagocytosis of outer R1-R6 photoreceptor cell rhabdomeres by neighbouring cells.

(Alloway et al., 2000)

The DHP-sensitive current is reduced. Application of TPA (phorbol 12-myrisatae 13-acetate) and PDD (phorbol 12,13-didecanoate), activators of PKC, rescues the current in mutant fibres without significantly affecting the normal current. 4αPDD (4α-phorbol 12,13-didecanoate), an inactive analog of PDD, does not affect the normal or mutant current. BIM (bisindolylmaleimide), an inhibitor of PKC, reduces the current in normal fibres without affecting the mutant current. DOG (sn-1,2-dioctanoyl-glycarol), analog of diacylglycerol increases the current in the mutant fibres.

(Gu and Singh, 1997)

The amplitude response to vapours of all odorants tested in the maxillary palp is not significantly different from wild type. The antennal response is also unaffected.

(Riesgo-Escovar et al., 1995)

Strong allele.

(Running Deer et al., 1995)

Males have red eyes. Flies are blind.

(Stark et al., 1993)

No difference in PIP₂ levels, judged by its immunoreactivity, between light and dark adapted photoreceptors.

(Suzuki and Hirosawa, 1992)

norpA⁷ partially suppresses the arrhythmicity of some homozygous e¹ flies.

(Newby and Jackson, 1991)

The major peak of phospholipase C activity seen in wild-type head extracts is missing from homozygous norpA⁷ head extracts.

(Toyoshima et al., 1990)

Flies are blind. There is no receptor potential, and photoreceptors appear to degenerate relatively late in adult life.

(Inoue et al., 1989)

The ocelli of 3 week old flies lack rhabdomeres, and there is an accumulation of debris under the cornea. The somata, projection and synapses of the receptor axons and interneurons appear normal, although occasionally abnormal striations on the soma's plasmalemma are seen.

(Stark et al., 1989)

norpA⁷ flies lack both the receptor potential and the transient components of the electroretinogram.

(Harris and Stark, 1977)

very small (<3mV) ERG, even with high intensity stimuli

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, non-enhanceable by imd¹

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, non-enhanceable by Fadd^f02804

(Chinchore et al., 2012)

Suppressed by

Statement

Reference

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by Dredd^B118

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by Rel^E20

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by Rel^E38/Rel^E20

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by key¹

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by key⁴/key¹

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, suppressible by BacA\p35^GMR.PH/Scer\GAL4^GMR.PU

(Chinchore et al., 2012)

NOT suppressed by

Statement

Reference

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, non-suppressible by Dark^G8

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, non-suppressible by imd¹

(Chinchore et al., 2012)

norpA^EE5 has abnormal neuroanatomy | adult stage | progressive | conditional phenotype, non-suppressible by Fadd^f02804

(Chinchore et al., 2012)

norpA^EE5 has abnormal neurophysiology phenotype, non-suppressible by Scer\GAL4^ninaE.PD/Pld^UAS.cLa

(LaLonde et al., 2005)

NOT Suppressor of

Statement

Reference

norpA^EE5/norpA^EE5 is a non-suppressor of abnormal locomotor behavior | adult stage | drug conditional phenotype of Rnor\P2rx2^UAS.cLa, Scer\GAL4^{shakB.lethal.4.1}

(Lima and Miesenbock, 2005)

norpA^EE5/norpA^EE5 is a non-suppressor of abnormal locomotor behavior | adult stage | drug conditional phenotype of Rnor\P2rx2^UAS.cLa, Scer\GAL4^c17

(Lima and Miesenbock, 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

norpA^EE5 has eye phenotype, enhanceable by CtsL1^EY05806/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, enhanceable by CtsL1^EY05806/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, enhanceable by CtsL1^EY05806/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has retina phenotype, enhanceable by Pld^null

(LaLonde et al., 2005)

NOT Enhanced by

Statement

Reference

norpA^EE5 has retina | progressive | conditional phenotype, non-enhanceable by imd¹

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, non-enhanceable by Fadd^f02804

(Chinchore et al., 2012)

Suppressed by

Statement

Reference

norpA^EE5 has retina | progressive | conditional phenotype, suppressible by BacA\p35^GMR.PH/Scer\GAL4^GMR.PU

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, suppressible by Dredd^B118

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, suppressible by Rel^E20

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, suppressible by Rel^E38/Rel^E20

(Chinchore et al., 2012)

norpA^EE5 has eye phenotype, suppressible by CtsL1^llcnbw38

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, suppressible by CtsL1^llcnbw38

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, suppressible by CtsL1^llcnbw38

(Kinser and Dolph, 2012)

norpA^EE5 has eye phenotype, suppressible by Cys^GMR.PK

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, suppressible by Cys^GMR.PK

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, suppressible by Cys^GMR.PK

(Kinser and Dolph, 2012)

norpA^EE5 has eye phenotype, suppressible by Spn42Da^unspecified/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, suppressible by Spn42Da^unspecified/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, suppressible by Spn42Da^unspecified/Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has eye phenotype, suppressible by Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, suppressible by Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, suppressible by Scer\GAL4^GMR.long

(Kinser and Dolph, 2012)

norpA^EE5 has retina | conditional | somatic clone phenotype, suppressible by AP-2α⁰⁶⁶⁹⁴

(Orem et al., 2006)

norpA^EE5 has eye photoreceptor cell | conditional | somatic clone phenotype, suppressible by AP-2α⁰⁶⁶⁹⁴

(Orem et al., 2006)

norpA^EE5 has rhabdomere | conditional | somatic clone phenotype, suppressible by AP-2α⁰⁶⁶⁹⁴

(Orem et al., 2006)

norpA^EE5 has retina | conditional | somatic clone phenotype, suppressible by Arr2^R393A

(Orem et al., 2006)

norpA^EE5 has eye photoreceptor cell | conditional | somatic clone phenotype, suppressible by Arr2^R393A

(Orem et al., 2006)

norpA^EE5 has rhabdomere | conditional | somatic clone phenotype, suppressible by Arr2^R393A

(Orem et al., 2006)

norpA^EE5 has retina | conditional | somatic clone phenotype, suppressible by Arr2^K391A

(Orem et al., 2006)

norpA^EE5 has eye photoreceptor cell | conditional | somatic clone phenotype, suppressible by Arr2^K391A

(Orem et al., 2006)

norpA^EE5 has rhabdomere | conditional | somatic clone phenotype, suppressible by Arr2^K391A

(Orem et al., 2006)

norpA^EE5 has retina phenotype, suppressible by Scer\GAL4^ninaE.PD/Pld^UAS.cLa

(LaLonde et al., 2005)

norpA^EE5 has retina phenotype, suppressible by Arr2^3KQ/Arr2⁵

(Lee et al., 2003)

norpA^EE5 has eye phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has retina phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R2 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R3 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R4 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R5 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R6 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R1 phenotype, suppressible by Arr2⁵

(Alloway et al., 2000)

NOT suppressed by

Statement

Reference

norpA^EE5 has retina | progressive | conditional phenotype, non-suppressible by Dark^G8

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, non-suppressible by imd¹

(Chinchore et al., 2012)

norpA^EE5 has retina | progressive | conditional phenotype, non-suppressible by Fadd^f02804

(Chinchore et al., 2012)

norpA^EE5 has eye phenotype, non-suppressible by cathD²⁴

(Kinser and Dolph, 2012)

norpA^EE5 has rhabdomere phenotype, non-suppressible by cathD²⁴

(Kinser and Dolph, 2012)

norpA^EE5 has ommatidium phenotype, non-suppressible by cathD²⁴

(Kinser and Dolph, 2012)

norpA^EE5 has retina phenotype, non-suppressible by Scer\GAL4^ninaE.PD/Pld^UAS.cLa

(LaLonde et al., 2005)

norpA^EE5 has rhabdomere R2 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R3 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R3 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R4 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R4 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R5 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R5 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R6 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R6 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has eye phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has eye phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has retina phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has retina phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R1 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R1 phenotype, non-suppressible by shi¹

(Alloway et al., 2000)

norpA^EE5 has rhabdomere R2 phenotype, non-suppressible by ninaE^Δ356

(Alloway et al., 2000)

Suppressor of

Statement

Reference

norpA^EE5 is a suppressor of eye phenotype of Arr2⁵

(Alloway et al., 2000)

norpA^EE5 is a suppressor of retina phenotype of Arr2⁵

(Alloway et al., 2000)

norpA^EE5 is a suppressor of ommatidium phenotype of Arr2⁵

(Alloway et al., 2000)

norpA^EE5 is a suppressor of phenotype of rdgB¹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R1 phenotype of rdgB⁹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R2 phenotype of rdgB⁹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R3 phenotype of rdgB⁹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R4 phenotype of rdgB⁹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R5 phenotype of rdgB⁹

(Harris and Stark, 1977)

norpA^EE5 is a suppressor of photoreceptor cell R6 phenotype of rdgB⁹

(Harris and Stark, 1977)

NOT Suppressor of

Statement

Reference

norpA^EE5 is a non-suppressor of retina phenotype of Arr2¹⁰

(Alloway et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

A Cp1^llcnbw38 mutant background rescues the eye degeneration seen in norpA⁷ mutants exposed to six days constant light.

A cathD²⁴ background does not suppress the photoreceptor cell death and degeneration seen in norpA⁷ mutants exposed to six days constant light.

Expression of Cys^GMR in norpA⁷ mutants fully rescues the retinal degeneration seen upon exposure to constant light for 6 days. This rescue is robust and provides protection when light exposure is extended to 8 days.

Overexpression of Spn42Da^unspecified in the eye under the control of Scer\GAL4^GMR.long suppresses retinal degeneration in norpA⁷ mutants. Ectopic expression of Spn42Da^unspecified results in rescue of endocytosis-mediated retinal degeneration resulting in robust rhabdomeres and an ordered array of rhabdomeres.

norpA⁷ mutants carrying Scer\GAL4^GMR.long require five weeks of light ot exhibit complete retinal degeneration due to the presence of screening pigment. Retinal degeneration in a red-eyed background not only takes longer but many rhabdomeres are not completely lost. Instead, there is a shrinking and malformation of the rhabdomeres and a loss of the ordered ommatidial array.

The retinal degeneration seen in norpA⁷ flies exposed to 4 weeks of constant light is accelerated when Cp1^EY05806 is expressed under the control of Scer\GAL4^GMR.long.

(Kinser and Dolph, 2012)

In α-Adaptin⁰⁶⁶⁹⁴,norpA⁷ double mutant eye clones, from animals raised in the dark and then exposed to 5 days of constant room light, retinal degeneration is rescued and eyes show wild-type morphology.

Arr2^K391A completely rescues the retinal degeneration observed in norpA⁷ mutant eyes from animals raised in the dark and then exposed to 5 days of constant room light.

Arr2^R393A completely rescues the retinal degeneration observed in norpA⁷ mutant eyes from animals raised in the dark and then exposed to 5 days of constant room light.

(Orem et al., 2006)

The absence of light-stimulated change in the membrane potential of retinal photoreceptors in norpA⁷ flies is not rescued by expressing Pld^Scer\UAS.cLa under the control of Scer\GAL4^ninaE.PD.

Expression of Pld^Scer\UAS.cLa under the control of Scer\GAL4^ninaE.PD partially suppresses the norpA⁷ retinal degeneration phenotype.

Retinas from Pld^null), norpA⁷ double mutant flies raised under continuous light conditions show a much more severe retinal degeneration phenotype than the norpA⁷ single mutants: at 1 day after eclosion, the double mutants already exhibit advanced degeneration (small rhabdomeres and decreased cell body size), while by 6 days after eclosion, retinal degeneration is extensive with only rhabdomeres R7 and R8 remaining.

(LaLonde et al., 2005)

norpA⁷/norpA⁷ rarely fly, but can be stimulated to by exposure to UV if the flies also carry Rnor\P2rx2^Scer\UAS.cLa with Scer\GAL4^c17 or Scer\GAL4^{shakB.lethal.4.1} and have had 40-70 mM DMNPE-ATP(*) microinjected into their CNS.

(Lima and Miesenbock, 2005)

The loss of the deep pseudopupil seen in norpA⁷ animals is suppressed by Arr2⁵/Arr2^3KQ, although the rhabdomeres of these animals reared for 2 weeks in a 12 hour light/12 hour dark cycle do not have normal morphology.

(Lee et al., 2003)

norpA⁷, Arr2⁵ double mutants completely rescue the degeneration observed in individual mutant and result in an ommatidial structure that closely resembles wild-type. The addition of ninaE^Δ356 to norpA⁷ mutants has no effect on the retinal phenotype. The addition of norpA⁷ to Arr2¹⁰ mutants has no effect on the retinal phenotype. The addition of shi¹ to norpA⁷ mutants partially rescued the light dependant retinal degeneration phenotype.

(Alloway et al., 2000)

norpA⁷ rdgB⁹ double mutants have normal looking R1-6 photoreceptors even after 20 days in constant light at 18^oC.

(Harris and Stark, 1977)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

norpA^suIII

(Harris and Stark, 1977)

norpA^suII

(Harris and Stark, 1977)

norpA^suI

(Harris and Stark, 1977)

Rescued by

norpA^EE5 is rescued by norpA^UAS.RFP(Unk)/Scer\GAL4^da.G32

(Ha et al., 2009)

norpA^EE5 is rescued by norpA^UAS.RFP(Unk)/Scer\GAL4^NP3084

(Ha et al., 2009)

Not rescued by

norpA^EE5 is not rescued by norpA^UAS.RFP(Unk)/Scer\GAL4^c564

(Ha et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

5685

108362

Notes on Origin

Discoverer

Benzer.

Comments

norpA RNA and protein expression, and phospholipase C activity have been studied in norpA⁷ flies.

(Zhu et al., 1993)

Phospholipase C activation is reduced in norpA⁷ mutants.

(Running Deer et al., 1995)

FlyBase curator comment: "norpA⁷" is stated to be the same as "norpA^P24" in FBrf0187818. However, this appears to have been an error (see Frohman, 2007.1.29, personal communication to FlyBase). The allele actually used in FBrf0187818 appears to be "norpA⁷".

(LaLonde et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

PLC-β-KO

(Ha et al., 2009)

norp⁷

(Lee et al., 2013)

norpA⁷

(Damulewicz et al., 2022, Tanaka and Clark, 2022, Schnaitmann et al., 2018, Mauss et al., 2015, Chaturvedi et al., 2014, Mauss et al., 2014, Haikala et al., 2013, Schnaitmann et al., 2013, Senthilan et al., 2012, Ha et al., 2009, Ha et al., 2009, Frohman, 2007.1.29, Liu et al., 2007, Wijnen et al., 2006, LaLonde et al., 2005, Lima and Miesenbock, 2005)

Name Synonyms

Secondary FlyBase IDs

References (46)

Report Sections

Open Close