FlyBase Gene Report: Dmel\CCT7

General Information

Symbol

Dmel\CCT7

Species

D. melanogaster

Name

Chaperonin containing TCP1 subunit 7

Annotation Symbol

CG8351

Feature Type

protein_coding_gene

FlyBase ID

FBgn0037632

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Tcp-1eta, Tcp-1η

Key Links

Genomic Location

Cytogenetic map

85B1-85B2

Sequence location

3R:8,801,564..8,806,234 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8801564..8806234

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012720

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012720

(InterPro Project Members, 2004-)

enables ATP-dependent protein folding chaperone

inferred from electronic annotation with InterPro:IPR017998

(InterPro Project Members, 2004-)

enables unfolded protein binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012720

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012720

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of chaperonin-containing T-complex

inferred from biological aspect of ancestor with PANTHER:PTN000143937

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX -: Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CCT7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VHL2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CCT7-RA

FBtr0081918

NM_141578

1964

544

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CCT7-PA

FBpp0081401

59.4

544

6.27

Q9VHL2

NP_649835

AAF54292

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VHL2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tcp-1eta_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.29

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{769.FSVS-1}CCT7^CPTI002629

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

Comment: large neurons in the adult brain cortex

(Knowles-Barley, 2011.8.24)

adult brain

Comment: low expression in neuropil throughout adult brain

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CCT7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CCT7

View exonic expression by tissue for Dmel\CCT7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41054/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037632

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037632

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037632

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8351

Flygut - An atlas of the Drosophila adult midgut

FBgn0037632

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CCT7

Transgenic constructs containing regulatory region of CCT7

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6150

(Ryder, 2004.4.26)

Df(3R)Exel8143

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

CCT7^CA07228

lethal, with Scer\GAL4^insc-Mz1407

CCT7^GD13899

lethal, with Scer\GAL4^pnr-MD237

CCT7^GD13899

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

CCT7^GD13899

lethal - all die during pharate adult stage, with Scer\GAL4^ey.PU

partially lethal, with Scer\GAL4^tin.CΔ4

CCT7^GD13899

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CCT7^GD13899

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

CCT7^GD13899

decreased size | adult stage, with Scer\GAL4^ey.PH

CCT7^VDRC.cUa

homeotic | adult stage, with Scer\GAL4^ey.PH

CCT7^VDRC.cUa

short lived, with Scer\GAL4^HCH.Hand

short lived, with Scer\GAL4^tin.CΔ4

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

CCT7^GD13899

visible | pharate adult stage, with Scer\GAL4^ey.PU

Phenotype manifest in

Allele

adult head | pharate adult stage, with Scer\GAL4^ey.PU

adult heart

CCT7^KG01477

adult heart, with Scer\GAL4^HCH.Hand

adult heart | progressive, with Scer\GAL4^tin.CΔ4

antenna | ectopic, with Scer\GAL4^ey.PH

CCT7^VDRC.cUa

cardiac myofibril | adult stage, with Scer\GAL4^tin.CΔ4

eye, with Scer\GAL4^ey.PH

CCT7^VDRC.cUa

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

CCT7^GD13899

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

CCT7^GD13899

sarcomere, with Scer\GAL4^Mef2.PR

CCT7^GD13899

Z disc, with Scer\GAL4^Mef2.PR

CCT7^GD13899

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\CCT7

14 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\BBS10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Cct7

14 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Cct8l1

1 of 14

Rnor\Cct8

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Cct7

13 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Cct6a

1 of 14

Mmus\Cct8l1

1 of 14

Mmus\Cct8

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\cct7

7 of 13

Yes

3 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\ctsa

1 of 13

Yes

Xtro\hspd1

1 of 13

Xtro\nat10

1 of 13

Xtro\tcp1

1 of 13

Danio rerio (Zebrafish) (11)

Drer\cct7

14 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\bbs10

1 of 14

Yes

Drer\cct6a

1 of 14

Drer\cct8

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\cct-7

13 of 14

Yes

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP002762

12 of 12

Yes

4 of 12

4 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\AT3G11830

13 of 13

Yes

4 of 13

4 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\CCT7

13 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\cct7

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Escherichia coli (enterobacterium) (1)

Ecol\groL

2 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CCT7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cardiac dysfunction (postulated), TRiC/CCT complex

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

CCT7^KG01477

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT7^GD13899

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT7^KK101540

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

model of sensory peripheral neuropathy

CEA

(Pavel et al., 2016)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CCT7^KK101540

model of sensory peripheral neuropathy

is ameliorated by Atg8a^KG07569

(Pavel et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCT7; chaperonin containing TCP1 subunit 7

14 of 14

605140

CCT2; chaperonin containing TCP1 subunit 2

4 of 14

605139

TCP1; t-complex 1

4 of 14

186980

CCT4; chaperonin containing TCP1 subunit 4

3 of 14

605142

CCT5; chaperonin containing TCP1 subunit 5

3 of 14

610150

NEUROPATHY, HEREDITARY SENSORY, WITH SPASTIC PARAPLEGIA, AUTOSOMAL RECESSIVE

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

CCT7 - Fmr1

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Monzo et al., 2010)

protein-protein

Physical Interaction

Assay

References

CCT7 - Akt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT7 - CCT1

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT3

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT4

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT5

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CCT8

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - CG33303

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Chc

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Cndp2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Cyp12d1-p

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - FASN1

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Fim

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Gp93

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Idh3a

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Kap-α3

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Karyβ3

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Lst8

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

CCT7 - MRP

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Ost48

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - OstΔ

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Past1

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Pc

anti bait coimmunoprecipitation, anti tag western blot

(Shaheen et al., 2021)

CCT7 - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT7 - Rpt1

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - SerRS

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - Vha68-2

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - fax

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - mst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Palumbo et al., 2015)

CCT7 - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT7 - spidey

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - viaf

experimental knowledge based

(Guruharsha et al., 2011)

CCT7 - wal

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Nsf2

suppressible

CCT7

(Laviolette et al., 2005)

enhanceable

CCT7

(Shaheen et al., 2021)

trx

suppressible

CCT7

(Shaheen et al., 2021)

upd1

suppressible

CCT7

(Mukherjee et al., 2006)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66226

DroID - A comprehensive database of gene and protein interactions.

FBgn0037632

MIST (protein-protein) - An integrated Molecular Interaction Database

41054

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85B1-85B2

Sequence location

3R:8,801,564..8,806,234 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85B1-85B2

Limits computationally determined from genome sequence between P{lacW}l(3)L4740^L4740 and P{EP}D1^EP473

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-45.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

83559

y¹ sc^* v¹ sev²¹; P{TKO.GS04346}attP40

34931

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01281}attP2

26487

w¹¹¹⁸; Mi{ET1}CCT7^MB09573 CG9839^MB09573/TM6C, Sb¹

13446

y¹; P{SUPor-P}CCT7^KG01477 ry⁵⁰⁶/TM3, Sb¹ Ser¹

15191

y¹; P{SUPor-P}CCT7^KG09501 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

115311

w¹¹¹⁸; PBac{769.FSVS-1}CCT7^CPTI002629

200804

w^*; P{GSV2}CCT7^GS5233/TM3, Sb¹ Ser¹

NIG-Fly

HMS01281

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01281}attP2

VDRC

v108585

P{KK101540}VIE-260B

v28895

w¹¹¹⁸; P{GD13899}v28895

v341347

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00402}attP40/CyO-GFP

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (66)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD47396

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0037632

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0037632

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-DGRC : S2 cells were stably transfected with pMT-FLAG-CCT7.
(Shaheen et al., 2021)

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tcp-1η CG8351

(Goshima et al., 2007)

Source for identity of: CCT7 Tcp-1η

(Monzo et al., 2010)

Nomenclature comments

FlyBase curator comment: Renamed from 'Tcp-1η' to 'CCT7' to unify the nomenclature used for the CCT/TRiC subunits in FlyBase, following the nomenclature used in this paper (FBrf0210519) and other species.

(Monzo et al., 2010)

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CCT7

(Heigwer et al., 2023, Deolankar et al., 2022, Känel et al., 2022, Perlegos et al., 2022, Kim and Choi, 2019)

CG8351

(Kolkhof et al., 2017, Çiçek et al., 2016, Hosono et al., 2015, Moutinho-Pereira et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Cammarato et al., 2011, Glatter et al., 2011, Ni et al., 2011.7.19, Monzo et al., 2010, Keleman et al., 2009.8.5, Dorogova et al., 2008, Hughes et al., 2008, Buszczak et al., 2007, Goshima et al., 2007, Quinones-Coello, 2007, Liebl et al., 2006, Mukherjee et al., 2006, Laviolette et al., 2005)

Cct7

(Melkani et al., 2017, Pavel et al., 2016, Monzo et al., 2010)

Q9VHL2_DROME

(Fukuyama et al., 2012)

T-cp1eta

(Ogneva et al., 2016)

T-cpleta

(Kupriyanova et al., 2016)

TCP1-eta

(Palumbo et al., 2015)

TCP1η

(Álvarez-Fernández et al., 2015)

TCPeta

(Völker-Albert et al., 2016)

Tcp-1-eta1

(Goshima et al., 2007)

Tcp-1eta

(Transgenic RNAi Project members, 2017-, Spratford and Kumar, 2015, Zirin et al., 2015, Kwon et al., 2013, Friedman et al., 2011, Neumüller et al., 2011, Rees et al., 2011, Kallappagoudar et al., 2010, Kong et al., 2010, Fisher et al., 2008)

Tcp-1η

(Monzo et al., 2010)

cct7

(Ohhara et al., 2019)

tcp-1eta

(Gill et al., 2015)

tcp1eta

(Gill et al., 2015)

Name Synonyms

CG8351

Chaperonin containing TCP1 subunit 7

TCP1-ζ homologue

(Moutinho-Pereira et al., 2013)

Tcp-1η

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41054

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VHL2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VHL2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VHL2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41054/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0037632

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0037632

FlyMine - An integrated database for Drosophila genomics

FBgn0037632

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8351

MARRVEL_MODEL - MARRVEL (model organism gene)

41054

Linkouts

BioGRID - A database of protein and genetic interactions.

66226

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0037632

DroID - A comprehensive database of gene and protein interactions.

FBgn0037632

DRSC - Results frm RNAi screens

FBgn0037632

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tcp-1eta_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037632

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0037632

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8351

Flygut - An atlas of the Drosophila adult midgut

FBgn0037632

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0037632

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005004

MIST (protein-protein) - An integrated Molecular Interaction Database

41054

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

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