FlyBase Gene Report: Dmel\CCT5

General Information

Symbol

Dmel\CCT5

Species

D. melanogaster

Name

Chaperonin containing TCP1 subunit 5

Annotation Symbol

CG8439

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010621

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Chaperonin containing TCP1 subunit 5 (CCT5) encodes a component of the TCP-1 ring complex (TRiC) chaperonin. It is involved in myofibril organization maintenance, cardiac physiological rhythm and lifespan determination. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)06444, T-complex Chaperonin 5

Key Links

Genomic Location

Cytogenetic map

48E4-48E4

Sequence location

2R:12,174,802..12,177,516 [+]

Recombination map

2-66

RefSeq locus

NT_033778 REGION:12174802..12177516

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR002423, InterPro:IPR012718

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR002194

(InterPro Project Members, 2004-)

enables ATP-dependent protein folding chaperone

inferred from electronic annotation with InterPro:IPR017998

(InterPro Project Members, 2004-)

enables unfolded protein binding

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012718

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein folding

inferred from biological aspect of ancestor with PANTHER:PTN004253040

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002194, InterPro:IPR012718

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of chaperonin-containing T-complex

inferred from biological aspect of ancestor with PANTHER:PTN000144283

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

Gene Group (FlyBase)

CHAPERONIN CONTAINING TCP-1 COMPLEX -: Group II Heat Shock Protein 60 chaperonins are paralogous subunits that assemble to form a multi-subunit ring complex, the TCP-1 Ring Complex (TRiC) or Chaperonin Containing TCP-1 (CCT) complex. Within the cytoplasm, TRiC/CCT catalyses the ATP-dependent folding of approximately 10% of of newly synthesized proteins. (Adapted from FBrf0210519, FBrf0232269 and PMID:11580267).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CCT5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KKI0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CCT5-RA

FBtr0087987

NM_078983

1948

542

CCT5-RB

FBtr0087988

NM_165867

1754

512

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CCT5-PA

FBpp0087095

59.3

542

6.17

FBpp0087096

55.8

512

6.01

A1Z8U4

NP_725107

AAM71027

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CCT5 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.70

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

organism

• pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CCT5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CCT5

View exonic expression by tissue for Dmel\CCT5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010621

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36308/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010621

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010621

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010621

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8439

Flygut - An atlas of the Drosophila adult midgut

FBgn0010621

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CCT5

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CCT5

Transgenic constructs containing regulatory region of CCT5

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)BSC699

(Christensen et al., 2008.12.28)

In(2R)vg^W

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)vg135

(BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

CCT5^GD13925

lethal, with Scer\GAL4^pnr-MD237

CCT5^GD13925

lethal | recessive

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

CCT5^GD13925

lethal - all die during pharate adult stage, with Scer\GAL4^ey.PU

partially lethal - majority die

CCT5⁰⁶⁴⁴⁴

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CCT5^GD13925

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

CCT5^GD13925

short lived, with Scer\GAL4^HCH.Hand

short lived, with Scer\GAL4^tin.CΔ4

visible | pharate adult stage, with Scer\GAL4^ey.PU

Phenotype manifest in

Allele

adult head | pharate adult stage, with Scer\GAL4^ey.PU

adult heart

CCT5^k06005

adult heart, with Scer\GAL4^HCH.Hand

adult heart | progressive, with Scer\GAL4^tin.CΔ4

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

CCT5^GD13925

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

CCT5^GD13925

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (14)

Hsap\CCT5

14 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\CCT8L1P

1 of 14

Hsap\CCT8L2

1 of 14

Hsap\VKORC1L1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (13)

Rnor\Cct5

14 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Bbs10

1 of 14

Rnor\Cct8l1

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Cct5

14 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Bbs10

1 of 14

Mmus\Cct8l1

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\cct5

11 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (10)

Drer\cct5

14 of 14

Yes

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\tcp1

2 of 14

Drer\cct2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\cct-5

13 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP008249

12 of 12

Yes

Agam\AgaP_AGAP009505

4 of 12

Agam\AgaP_AGAP012475

4 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\AT1G24510

13 of 13

Yes

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\CCT5

13 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\cct5

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

Escherichia coli (enterobacterium) (1)

Ecol\groL

2 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CCT5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (12)

6 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cardiac dysfunction (postulated), TRiC/CCT complex

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 4 )

Allele

Disease

Evidence

References

CCT5^k06005

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT5^GD13925

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

CCT5^KK108095

model of intrinsic cardiomyopathy

CEA

(Melkani et al., 2017)

model of sensory peripheral neuropathy

CEA

(Pavel et al., 2016)

CCT5^NIG.8439R

model of sensory peripheral neuropathy

CEA

(Pavel et al., 2016)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

CCT5^KK108095

model of sensory peripheral neuropathy

is ameliorated by Atg8a^KG07569

(Pavel et al., 2016)

CCT5^NIG.8439R

model of sensory peripheral neuropathy

is ameliorated by Atg8a^KG07569

(Pavel et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCT5; chaperonin containing TCP1 subunit 5

14 of 14

610150

NEUROPATHY, HEREDITARY SENSORY, WITH SPASTIC PARAPLEGIA, AUTOSOMAL RECESSIVE

CCT3; chaperonin containing TCP1 subunit 3

4 of 14

600114

CCT4; chaperonin containing TCP1 subunit 4

4 of 14

605142

CCT2; chaperonin containing TCP1 subunit 2

3 of 14

605139

CCT6A; chaperonin containing TCP1 subunit 6A

3 of 14

104613

CCT6B; chaperonin containing TCP1 subunit 6B

3 of 14

610730

CCT7; chaperonin containing TCP1 subunit 7

3 of 14

605140

TCP1; t-complex 1

3 of 14

186980

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CCT5 - Akt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT5 - CCT1

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT2

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT3

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT4

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT7

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - CCT8

experimental knowledge based

(Guruharsha et al., 2011)

CCT5 - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT5 - S6k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT5 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

CCT5 - coil

two hybrid

(Hu et al., 2017.6.13)

CCT5 - mst

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Palumbo et al., 2015)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

CCT5

(Shaheen et al., 2021)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62089

DroID - A comprehensive database of gene and protein interactions.

FBgn0010621

MIST (protein-protein) - An integrated Molecular Interaction Database

36308

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-66

Cytogenetic map

48E4-48E4

Sequence location

2R:12,174,802..12,177,516 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

48E4-48E4

Limits computationally determined from genome sequence between P{PZ}SmD3⁰²⁸³³ and P{PZ}Cam⁰³⁹⁰⁹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

48E10-48E11

(determined by in situ hybridisation)

(Spradling et al., 1999)

48E10-48E11

48E6--9 48E8--11

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-66

(FlyBase, 2016)

2-67.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41818

y¹ v¹; P{TRiP.GL01246}attP2

12315

P{PZ}CCT5⁰⁶⁴⁴⁴ cn¹/CyO; ry⁵⁰⁶

10393

y¹ w^67c23; P{lacW}CCT5^k06005/CyO

78122

y¹ sc^* v¹ sev²¹; P{TOE.GS01245}attP40

83763

y¹ sc^* v¹ sev²¹; P{TKO.GS03483}attP40

57440

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04747}attP40

Kyoto

111085

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}CCT5^k06005 /CyO y⁺

NIG-Fly

2RG-1163

y² VhaAC39-1^cho-1 v¹; P{U6-CCT5.NIG.sgRNA}attP40/CyO

VDRC

v109505

P{KK108095}VIE-260B

v24098

w¹¹¹⁸ P{GD13925}v24098

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (183)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GM12270

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010621

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010621

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene in S2 cell results in dim staining of microtubules, and a short monopolar spindle. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CCT5 Cct5

(Monzo et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BcDNA.GM12270

(Tsang, 1999.7.26)

BcDNA:GM12270

CCT5

(Hung et al., 2020, Wang et al., 2020, Kim and Choi, 2019, Hu et al., 2017.6.13, Völker-Albert et al., 2016, Monzo et al., 2010)

CG8439

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Moutinho-Pereira et al., 2013, Monzo et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Goshima et al., 2007)

TCP-1ε

(Monzo et al., 2010)

TCP1-epsilon

(Palumbo et al., 2015)

Tcp1-epsilon

(Fisher et al., 2008)

cct5

(Ohhara et al., 2019, Gill et al., 2015)

l(2)06444

(Beaton, 2000.1.31, Jackle and Janning, 1998.8.10, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

Chaperonin containing TCP1 subunit 5

T-complex Chaperonin 5

(Moutinho-Pereira et al., 2013, McGraw et al., 2008, Spradling et al., 1999)

Secondary FlyBase IDs

FBgn0027913

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36308

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KKI0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KKI0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010621

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36308/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010621

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010621

FlyMine - An integrated database for Drosophila genomics

FBgn0010621

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8439

MARRVEL_MODEL - MARRVEL (model organism gene)

36308

Linkouts

BioGRID - A database of protein and genetic interactions.

62089

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010621

DroID - A comprehensive database of gene and protein interactions.

FBgn0010621

DRSC - Results frm RNAi screens

FBgn0010621

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010621

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010621

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8439

Flygut - An atlas of the Drosophila adult midgut

FBgn0010621

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010621

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007744

MIST (protein-protein) - An integrated Molecular Interaction Database

36308

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (90)

The following external sites may use different assemblies or annotations than FlyBase.

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