FlyBase Gene Report: Dmel\Tfb1

General Information

Symbol

Dmel\Tfb1

Species

D. melanogaster

Name

Transcription factor B1

Annotation Symbol

CG8151

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033929

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Transcription factor B1 (Tfb1) encodes a subunit of the Transcription factor II H complex (TFIIH). TFIIH operates in RNA polymerase I and II-mediated transcription, DNA repair and cell cycle regulation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(2)06949, p62, TfBl

Key Links

Genomic Location

Cytogenetic map

50F6-50F6

Sequence location

2R:14,363,048..14,365,473 [+]

Recombination map

2-70

RefSeq locus

NT_033778 REGION:14363048..14365473

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (9 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in response to UV

inferred from mutant phenotype

(Castro et al., 2002)

Terms Based on Predictions or Assertions (8 terms)

CV Term

Evidence

References

involved_in DNA repair

inferred from biological aspect of ancestor with PANTHER:PTN000304482

(GO Reference Genome Project, 2011-)

involved_in DNA-templated transcription

inferred from electronic annotation with InterPro:IPR027079

(InterPro Project Members, 2004-)

involved_in nucleotide-excision repair

inferred from sequence or structural similarity with HGNC:4655

(Castro et al., 2002)

inferred from electronic annotation with InterPro:IPR027079

(InterPro Project Members, 2004-)

involved_in RNA polymerase II promoter clearance

inferred from sequence or structural similarity with HGNC:4655

(Castro et al., 2002)

involved_in transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000304482

(GO Reference Genome Project, 2011-)

involved_in transcription by RNA polymerase I

inferred from biological aspect of ancestor with PANTHER:PTN000304482

(GO Reference Genome Project, 2011-)

involved_in transcription initiation at RNA polymerase II promoter

inferred from sequence or structural similarity with HGNC:4655

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000002719

(Aoyagi and Wassarman, 2000)

involved_in transcription open complex formation at RNA polymerase II promoter

inferred from sequence or structural similarity with HGNC:4655

(Castro et al., 2002)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of transcription factor TFIIH holo complex

inferred from direct assay

(Aguilar-Fuentes et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in nucleus

inferred from sequence or structural similarity with HGNC:4655

(Castro et al., 2002)

inferred from sequence or structural similarity with SGD:S000002719

(Castro et al., 2002)

part_of transcription factor TFIIH core complex

inferred from biological aspect of ancestor with PANTHER:PTN000304482

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR027079

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with HGNC:4655

(Castro et al., 2002)

inferred from sequence or structural similarity with SGD:S000002719

(Castro et al., 2002)

part_of transcription factor TFIIH holo complex

inferred from sequence or structural similarity with HGNC:4655

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with SGD:S000002719

(Aoyagi and Wassarman, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000304482

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II H - CORE COMPLEX

Protein Family (UniProt)

Belongs to the TFB1 family. (Q960E8)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TRANSCRIPTION FACTOR II H - CORE COMPLEX -: The general transcription factor complex Transcription factor II H (TFIIH) core complex, is a subcomplex of the TFIIH holoenzyme required in RNA pol II transcription with an ATP-dependent DNA helicase activity required for promoter DNA opening. TFIIH also functions in nucleotide excision repair (NER). After complex loading and the verification step of NER, the cyclin-dependent protein kinase-activating kinase (CAK) subcomplex dissociates and the TFIIH core complex functions independently. (Adapted from PMID:25693126, PMID:21592869 and PMID:30798933).

Protein Function (UniProtKB)

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

(UniProt, Q960E8)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tfb1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q960E8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tfb1-RA

FBtr0087550

NM_166048

2145

585

Tfb1-RB

FBtr0087548

NM_137113

2025

585

Tfb1-RC

FBtr0087549

NM_166049

2022

585

Tfb1-RD

FBtr0305616

NM_001259392

2018

585

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tfb1-PA

FBpp0086678

66.3

585

9.27

FBpp0086676

66.3

585

9.27

FBpp0086677

66.3

585

9.27

FBpp0294063

66.3

585

9.27

Q960E8

NP_001246321

AFH08075

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

585 aa isoforms: Tfb1-PA, Tfb1-PB, Tfb1-PC, Tfb1-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.

(UniProt, Q960E8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tfb1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tfb1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.37

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Castro et al., 2002)

Additional Descriptive Data

RT-PCR analysis indicates that transcript is present in all stages of development. Expression is higher in gastrulating embryos and transcript is expressed preferentially in adult males.

(Castro et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of transcription factor TFIIH holo complex

inferred from direct assay

(Aguilar-Fuentes et al., 2008)

Expression Deduced from Reporters

Reporter: P{PZ}Tfb1⁰⁶⁹⁴⁹

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | medial

(Castro et al., 2002)

adult stage | female

alimentary canal & pericardial cell

(Castro et al., 2002)

adult stage | male

alimentary canal & testis & pericardial cell

(Castro et al., 2002)

wandering third instar larval stage

embryonic/larval brain

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tfb1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tfb1

View exonic expression by tissue for Dmel\Tfb1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033929

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36598/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033929

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033929

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033929

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8151

Flygut - An atlas of the Drosophila adult midgut

FBgn0033929

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tfb1

Transgenic constructs containing regulatory region of Tfb1

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene not disrupted in

Df(2R)03072

(Bischoff et al., 2009, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)trix

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene disrupted in

Df(2R)BSC700

(Christensen et al., 2008.12.28)

Df(2R)ΔP1201

(Dickson et al., 1995)

Df(2R)trix

(Dickson et al., 1995)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | conditional

Tfb1⁰⁶⁹⁴⁹

lethal | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Tfb1^GD4074

viable, with Scer\GAL4^tin.CΔ4

Tfb1^GD4074

Other Phenotypes

Allele

radiation sensitive | dominant

Tfb1⁰⁶⁹⁴⁹

some die during pupal stage, with Scer\GAL4^pnr-MD237

Tfb1^GD4074

visible, with Scer\GAL4^pnr-MD237

Tfb1^GD4074

Phenotype manifest in

Allele

adult cuticle | conditional

Tfb1⁰⁶⁹⁴⁹

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Tfb1^GD4074

trichogen cell, with Scer\GAL4^pnr-MD237

Tfb1^GD4074

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\GTF2H1

14 of 14

Yes

Hsap\PICK1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Gtf2h1

14 of 14

Yes

Rnor\Pick1

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Gtf2h1

13 of 14

Yes

Mmus\Pick1

1 of 14

Xenopus tropicalis (Western clawed frog) (3)

Xtro\gtf2h1

8 of 13

Yes

Xtro\hmox1

6 of 13

Yes

Xtro\cer1

1 of 13

Yes

Danio rerio (Zebrafish) (2)

Drer\gtf2h1

14 of 14

Yes

Drer\pick1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\gtf-2H1

13 of 14

Yes

Cele\Y57G11C.22

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP011110

12 of 12

Yes

Agam\AgaP_AGAP007832

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\AT1G55750

13 of 13

Yes

Atha\AT3G61420

13 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TFB1

9 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\tfb1

7 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tfb1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

PICK1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GTF2H1; general transcription factor IIH subunit 1

14 of 14

189972

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tfb1 - Ssl1

anti bait coimmunoprecipitation, western blot

(Aguilar-Fuentes et al., 2008)

Tfb1 - hay

anti bait coimmunoprecipitation, western blot

(Villicaña et al., 2013)

Tfb1 - p53

anti bait coimmunoprecipitation, western blot

(Villicaña et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q960E8 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62348

DroID - A comprehensive database of gene and protein interactions.

FBgn0033929

MIST (protein-protein) - An integrated Molecular Interaction Database

36598

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-70

Cytogenetic map

50F6-50F6

Sequence location

2R:14,363,048..14,365,473 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50F6-50F6

Limits computationally determined from genome sequence between P{lacW}l(2)s3475^s3475&P{lacW}Hsc70-5^k04907 and P{PZ}Tfb1⁰⁶⁹⁴⁹&P{PZ}l(2)03563⁰³⁵⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

51A1-51A2

(determined by in situ hybridisation)

(Spradling et al., 1999)

51A1-51A2

51A1--5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-70

(FlyBase, 2016)

2-75.4

(Comeron et al., 2012)

(Dickson et al., 1995)

Left of (cM)

Right of (cM)

phyl

(Dickson et al., 1995)

Notes

17 recombinants in 29,738 progeny.

(Dickson et al., 1995)

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

57891

y¹ w^*; Mi{MIC}Tfb1^MI12186

12329

P{PZ}Tfb1⁰⁶⁹⁴⁹ cn¹/CyO; ry⁵⁰⁶

10398

y¹ w^67c23; P{lacW}Tfb1^k06203/CyO

19653

y¹ w^67c23; P{EPgy2}Tfb1^EY02347/CyO

80022

y¹ sc^* v¹ sev²¹; P{TOE.GS02952}attP40

57409

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04714}attP40

NIG-Fly

HMJ24101

y¹ v¹; P{TRiP.HMJ24101}attP40/CyO

2RG-0306

y² VhaAC39-1^cho-1 v¹; P{U6-Tfb1.NIG.sgRNA}attP40/CyO

VDRC

v12580

w¹¹¹⁸; P{GD4074}v12580

v12581

w¹¹¹⁸; P{GD4074}v12581

v341751

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00873}attP40/CyO-GFP

v341924

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01190}attP40/CyO-GFP

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (39)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD04652

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033929

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033929

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Tfb1 heterozygotes are more sensitive to UV light irradiation than normal.

(Castro et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Tfb1 l(2)06949

(Castro et al., 2002)

Additional comments

"Tfb1" may correspond to "Scim25". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim25" near/in "Tfb1" or "CG13941".

(Dobie and Karpen, 2001.4.18)

"l(2)06949" probably corresponds to "CG8151"; the P{PZ} insertion in the "l(2)06949⁰⁶⁹⁴⁹" allele maps 35bp upstream of the 5' end of the CT24236 transcript of "CG8151".

(Misra, 2000.11.18)

Nomenclature History

Source for database identify of

Source for identity of: Tfb1 CG8151

(Aoyagi and Wassarman, 2000)

Nomenclature comments

Etymology

Named "Tfb1" after the S. cerevisiae ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Name Synonyms

TFB1 ortholog

TfBl

(Bischoff et al., 2009)

Tfb1

(Davis et al., 2011)

Transcription factor B1

Secondary FlyBase IDs

FBgn0010631

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 70 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36598

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q960E8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q960E8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4K726

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q960E8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033929

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36598/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033929

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033929

FlyMine - An integrated database for Drosophila genomics

FBgn0033929

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8151

MARRVEL_MODEL - MARRVEL (model organism gene)

36598

Linkouts

BioGRID - A database of protein and genetic interactions.

62348

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033929

DroID - A comprehensive database of gene and protein interactions.

FBgn0033929

DRSC - Results frm RNAi screens

FBgn0033929

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tfb1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033929

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033929

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8151

Flygut - An atlas of the Drosophila adult midgut

FBgn0033929

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033929

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007976

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

36598

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (61)

The following external sites may use different assemblies or annotations than FlyBase.

2.37

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