Pglym78, Phosphoglyceromutase, Pglym, phosphoglycerate mutase, Phosphoglyceromutase 78
Please see the JBrowse view of Dmel\Pgam1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
1.0 (northern blot)
192 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgam1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: rapidly degraded
Pgam1 transcripts are very abundant in the earliest embryonic stages. They become undetectable as embryogenesis proceeds and are detected again in 12hr embryos. During larval, pupal, and adult stages, levels rise, fall, and then rise again in a pattern similar to that of transcripts of other glycolytic genes.
Glycolytic enzymes, including Pgam1 protein are localized to M bands and Z discs, as visualized in the isolated myofibrils of flight muscles, where immunoreactivity appears as alternating bright and less-intense bands.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pgam1 in JBrowse3-97
3-94.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Characterisation of Pglym78 reveals it shares properties to other genes that encode enzymes of the glycolytic pathway: promoter region with no TATA box but multiple closely spaced transcription initiation sites and a similar expression pattern. Comparison of the gene structure of Pglym78 and Pglym87 suggests that Pglym87 arose through retrotransposition from a Pglym78 transcript, additional more complex mechanisms may have played some role in the origin of Pglym87.
Source for identity of: Pglym78 CG1721
Source for identity of: Pgam1 Pglym78
Renamed from 'Pglym78' to 'Pgam1' to (i) remove the species-specific reference to cytogenetic location (which is erroneously given as '78' when the gene maps to 98F); (ii) use the more widely used nomenclature prefix for this gene across species.