D-La, 38C.38, DLa/SS-B
Please see the JBrowse view of Dmel\La for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
1.6 (northern blot)
1.5 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
390 (aa); 44.9 (kD predicted)
390 (aa); 52 (kD observed); 45 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\La using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as embryonic central brain mushroom body
The 1.6 kb La transcript is detected in embryonic, larval, pupal and adult stages. In situ localization shows that it is not expressed in all ovary cells. Nurse cells express La throughout oogenesis, and follicle cells express La only up to stage S9. Oocytes express very little La at stages S10-S14. Peritoneal sheath cells express La. Its generalized expression in early embryogenesis becomes restricted to mesodermal expression by stage 7. Expression is restricted to the visceral mesoderm and gonad starting at stage 13. At stag 17, La is expressed in the salivary gland.
In S2 cells, La protein localizes to the nucleus.
JBrowse - Visual display of RNA-Seq signals
View Dmel\La in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.