FlyBase Gene Report: Dmel\Itgbn

General Information

Symbol

Dmel\Itgbn

Species

D. melanogaster

Name

Integrin betanu subunit

Annotation Symbol

CG1762

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010395

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth. (UniProt, Q27591)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

βν, betaInt-nu, βInt-ν, βv, βν integrin

Key Links

Genomic Location

Cytogenetic map

39A1-39A1

Sequence location

2L:21,053,033..21,058,044 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:21053033..21058044

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein heterodimerization activity

inferred from physical interaction with FLYBASE:scb; FB:FBgn0286785

(Nonaka et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables integrin binding

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in apoptotic cell clearance

inferred from mutant phenotype

(Nonaka et al., 2013)

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Howell et al., 2012)

involved_in muscle cell cellular homeostasis

inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003

(Kucherenko et al., 2011)

involved_in negative regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Tsai et al., 2012, Tsai et al., 2008)

involved_in phagocytosis

inferred from mutant phenotype

(Nonaka et al., 2013)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in cell adhesion mediated by integrin

inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657

(Gene Ontology Curators, 2002-)

involved_in cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

involved_in cell-matrix adhesion

traceable author statement

(Hynes and Zhao, 2000)

involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

traceable author statement

(Hynes and Zhao, 2000)

involved_in integrin-mediated signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of integrin complex

inferred from direct assay

(Nonaka et al., 2013)

located_in membrane

inferred from direct assay

(Nonaka et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cell surface

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

is_active_in focal adhesion

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

part_of integrin complex

traceable author statement

(Hynes and Zhao, 2000)

inferred from sequence or structural similarity

(Brown, 2000)

non-traceable author statement

(Brower, 2003)

inferred from biological aspect of ancestor with PANTHER:PTN000801545

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657

(Yee and Hynes, 1993)

Gene Group (FlyBase)

INTEGRINS

Protein Family (UniProt)

Belongs to the integrin beta chain family. (Q27591)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

INTEGRINS -: Integrins are heterodimeric transmembrane receptors composed of an α and β subunit that mediate cell-cell and cell-extracellular matrix adhesion. As well as maintaining tissue integrity, they are involved in morphogenesis and development. (Adapted from FBrf0167428).

Protein Function (UniProtKB)

(UniProt, Q27591)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Itgbn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q27591)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Itgbn-RA

FBtr0081461

NM_078884

3340

799

Itgbn-RB

FBtr0346711

NM_001316404

3076

799

Additional Transcript Data and Comments

Reported size (kB)

3.6 (longest cDNA)

(Yee and Hynes, 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Itgbn-PA

FBpp0080990

90.8

799

4.41

FBpp0312322

90.8

799

4.41

Q27591

NP_001303333

ALI30216

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

799 aa isoforms: Itgbn-PA, Itgbn-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

799 (aa); 130 (kD observed)

(Yee and Hynes, 1993)

Comments

External Data

Subunit Structure (UniProtKB)

Heterodimer of an alpha and a beta subunit. Interacts with scb/alpha-PS3.

(UniProt, Q27591)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Itgbn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Itgbetanu_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.43

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

endoderm of midgut

(Yee and Hynes, 1993)

embryonic stage -- adult stage

(Yee and Hynes, 1993)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

midgut imaginal island

(Yee and Hynes, 1993)

embryonic/larval proventriculus

(Yee and Hynes, 1993)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

endoderm of midgut

(Yee and Hynes, 1993)

larval stage

larval hindgut imaginal ring

(Yee and Hynes, 1993)

gastric caecum

(Yee and Hynes, 1993)

Additional Descriptive Data

βInt-ν protein is found exclusively in the developing midgut endoderm in embryos. Unlike the mRNA, there is no gradient of βInt-ν protein expression in the midgut. In larvae, expression is observed in the midgut imaginal islands, in the gastric caecae, and in the hindgut imaginal ring. Low levels are observed in the proventriculus.

(Yee and Hynes, 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of integrin complex

inferred from direct assay

(Nonaka et al., 2013)

located_in membrane

inferred from direct assay

(Nonaka et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Itgbn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Itgbn

View exonic expression by tissue for Dmel\Itgbn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010395

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35368/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010395

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010395

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010395

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1762

Flygut - An atlas of the Drosophila adult midgut

FBgn0010395

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Itgbn

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Itgbn

Transgenic constructs containing regulatory region of Itgbn

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)DS6

(Reuter et al., 1993)

Df(2L)Exel7080

(Ryder, 2004.4.26)

Df(2L)pr-A14

(Reuter et al., 1993)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal immune response | larval stage

Itgbn^BG01037

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

Itgbn^EP2235

abnormal neuroanatomy | third instar larval stage

Itgbn¹

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PU

Itgbn^UAS.cTa

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^nSyb.PS

Itgbn^GD2503

abnormal neuroanatomy | third instar larval stage (with Itgbn¹)

Itgbn²

abnormal neuroanatomy | third instar larval stage (with Itgbn²)

Itgbn¹

abnormal sleep

Itgbn^BG01037

abnormal smell perception

Itgbn^BG01037

flightless, with Scer\GAL4^Mef2.PR

Itgbn^GD14392

visible, with Scer\GAL4^pnr-MD237

Itgbn^GD14392

Phenotype manifest in

Allele

anterior fascicle & synapse, with Scer\GAL4^elav-C155

Itgbn^EP2235

embryonic/larval hemocyte

embryonic/larval hemocyte, with Scer\GAL4^srp.Hemo

Itgbn^NIG.1762R

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

Itgbn^NIG.1762R

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

Itgbn^GD2503

larval intersegmental nerve, with Scer\GAL4^elav-C155

Itgbn^EP2235

neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PU

Itgbn^UAS.cTa

neuromuscular junction | third instar larval stage (with Itgbn¹)

Itgbn²

neuromuscular junction | third instar larval stage (with Itgbn²)

Itgbn¹

NMJ bouton | increased number | third instar larval stage

Itgbn¹

NMJ bouton | increased number | third instar larval stage (with Itgbn¹)

Itgbn²

NMJ bouton | increased number | third instar larval stage (with Itgbn²)

Itgbn¹

trichogen cell, with Scer\GAL4^pnr-MD237

Itgbn^GD14392

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (13)

Hsap\ITGB3

6 of 14

Yes

Hsap\ITGB5

6 of 14

Yes

Hsap\ITGB6

6 of 14

Yes

Hsap\ITGB1

5 of 14

Hsap\ITGB4

5 of 14

Yes

Hsap\ITGB7

5 of 14

Hsap\ITGB8

5 of 14

Yes

4 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Itgb6

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Rnor\Itgb3

4 of 14

Rnor\Itgb4

4 of 14

Yes

Rnor\Itgbl1

3 of 14

Rnor\Itgb5

1 of 14

Yes

Rnor\Tenm3

1 of 14

Rnor\Tnc

1 of 14

Rnor\Tnr

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Itgb3

6 of 14

Yes

Mmus\Itgb5

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Mmus\Itgb6

5 of 14

Mmus\Itgb7

5 of 14

Mmus\Itgb8

5 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (16)

Xtro\itgb2

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\mmd

2 of 13

Xtro\cep295

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\itgb8

1 of 13

Xtro\polr1f

1 of 13

Xtro\rnf112

1 of 13

Yes

Xtro\trim44

1 of 13

Yes

Danio rerio (Zebrafish) (22)

Drer\itgb3a

6 of 14

Yes

Drer\itgb3b

6 of 14

Yes

Drer\itgb5

6 of 14

Yes

Drer\itgb6

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Drer\itgb7

5 of 14

Drer\itgb2

4 of 14

Drer\itgb8

4 of 14

Yes

Drer\itgb1b

3 of 14

Drer\itgbl1

3 of 14

Drer\LOC110437890

2 of 14

Yes

Drer\si:dkey-237h12.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\pat-3

5 of 14

Yes

Cele\C05D9.3

2 of 14

Yes

Cele\ten-1

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP010233

12 of 12

Yes

3 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Itgbn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

mys

6 of 13

LRP1

1 of 13

Ten-a

1 of 13

Ten-m

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ITGB6; integrin subunit beta 6

model of amelogenesis imperfecta type 1H

IEA

(FlyBase, 2019-)

ITGB4; integrin subunit beta 4

model of junctional epidermolysis bullosa with pyloric atresia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Itgbn^BG01037

exacerbates muscular dystrophy

modeled by Dg^O86

(Kucherenko et al., 2011)

Itgbn^HM05089

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Hernandez et al., 2023)

Itgbn^HMJ23472

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-231.UAS}

(Hernandez et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ITGB3; integrin subunit beta 3

6 of 14

173470

ITGB5; integrin subunit beta 5

6 of 14

147561

ITGB6; integrin subunit beta 6

6 of 14

147558

AMELOGENESIS IMPERFECTA, TYPE IH; AI1H

amelogenesis imperfecta type 1H

ITGB1; integrin subunit beta 1

5 of 14

135630

ITGB4; integrin subunit beta 4

5 of 14

147557

junctional epidermolysis bullosa with pyloric atresia

ITGB7; integrin subunit beta 7

5 of 14

147559

ITGB8; integrin subunit beta 8

5 of 14

604160

ITGB2; integrin subunit beta 2

4 of 14

600065

LEUKOCYTE ADHESION DEFICIENCY, TYPE I; LAD1

leukocyte adhesion deficiency 1

ITGBL1; integrin subunit beta like 1

3 of 14

604234

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Itgbn - scb

anti bait coimmunoprecipitation, western blot

(Nonaka et al., 2013)

Itgbn - wun2

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Gao et al., 2022)

RNA-RNA

Physical Interaction

Assay

References

Itgbn - mir-184

luminiscence technology

(Iovino et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Itgbn

enhanceable

drpr

(Nagaosa et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

drpr

enhanceable

Itgbn

(Nagaosa et al., 2011)

eas

suppressible

Itgbn

(Hekmat-Scafe et al., 2005)

fz2

suppressible

Itgbn

(Tsai et al., 2012)

mys

enhanceable

Itgbn

(Lin et al., 2013, Devenport and Brown, 2004)

suppressible

(Lin et al., 2013)

suppressible

(Tsai et al., 2012)

External Data

Subunit Structure (UniProtKB)

Heterodimer of an alpha and a beta subunit. Interacts with scb/alpha-PS3.

(UniProt, Q27591 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010395

MIST (protein-protein) - An integrated Molecular Interaction Database

35368

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

39A1-39A1

Sequence location

2L:21,053,033..21,058,044 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39A1-39A1

Limits computationally determined from genome sequence between P{PZ}l(2)38EFd⁰⁴⁵³⁰ and P{PZ}l(2)05287⁰⁵²⁸⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

38B-38B

(Yee, 1993.8.26)

39B-39B

(determined by in situ hybridisation)

(Yee and Hynes, 1993)

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

600168

w^*; Itgbn²

12532

w¹¹¹⁸; P{GT1}Itgbn^BG01037

24022

w¹¹¹⁸; Mi{ET1}Itgbn^MB02607

28601

y¹ v¹; P{TRiP.HM05089}attP2

61916

y¹ v¹; P{TRiP.HMJ23472}attP40

93832

y¹ w^*; TI{CRIMIC.TG4.1}Itgbn^{CR70314-TG4.1}/SM6a

NIG-Fly

HMJ23472

y¹ v¹; P{TRiP.HMJ23472}attP40/CyO

M2L-0661

y¹ w¹¹¹⁸; Itgbn^SK3 P{neoFRT}40A/CyO-Tb

M2L-0662

y¹ w¹¹¹⁸; Itgbn^SK4 P{neoFRT}40A/CyO-Tb

VDRC

v40895

w¹¹¹⁸; P{GD2503}v40895

v42235

w¹¹¹⁸; P{GD14392}v42235

v318193

PBac{fTRG00698.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD14269

Other clones

LD09848

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010395

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010395

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Shiratsuchi et al., 2012, Nagaosa et al., 2011, Yee and Hynes, 1993)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila Integrin beta subunit gene, Acc. No. L13305. Probable Intron in Drosophila integrin gene.

(Davies, 2001.3.15)

Embryos transheterozygous for deficiencies that remove βInt-ν develop a normal midgut.

(Reuter et al., 1993)

The βInt-ν gene was identified by PCR, and is expressed in the embryonic midgut endoderm, larval midgut and the midgut adult imaginal cells.

(Yee and Hynes, 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: βInt-ν CG1762

(Adams, 1999.11)

Source for identity of: Itgbn βInt-ν

(Brown et al., 2013.2.5)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (45)

Reported As

Symbol Synonym

CG1762

(National Institute of Genetics Fly Stocks, 2022-, Hadar et al., 2012, Howell et al., 2012, Perkins et al., 2009, Kraut et al., 2001, Kraut et al., 2001)

CT5192

(Hynes and Zhao, 2000)

Fly βν

(Takada et al., 2007, Takada et al., 2007)

ITGβ PSv

(Hernandez et al., 2023)

Integrinβν

(Péan and Dionne, 2014)

Itgbn

(Huang et al., 2023, Kim et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Parra and Johnston, 2020, Yildirim et al., 2019, Gene Disruption Project members, 2018-, Mossman et al., 2016, Brown et al., 2013.2.5, Iovino et al., 2009)

Itgβnu

(Olivares et al., 2023)

Itgβv

(Ferguson et al., 2021, Pastor-Pareja, 2020)

Itgβν

(Xu et al., 2019, Brown et al., 2013.2.5)

betaInt

(Hadar et al., 2012)

betaInt-nu

(Sarov et al., 2016, Nainu et al., 2015, Nonaka et al., 2013, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Shiratsuchi et al., 2012, Nagaosa et al., 2011, Smith et al., 2011, Badal et al., 2006)

betaV-integrin

(Kucherenko et al., 2011)

integrin betaPs

(Xiao, 2022)

intβν

(Hernández de Madrid and Casanova, 2018)

Β_ν

(Reuter et al., 1993, Yee and Hynes, 1993)

β integrin

(Hughes et al., 2020, Hung et al., 2020, Sun et al., 2019)

β-Integrin

(D'Souza et al., 2022)

β-ν

(Hughes, 2001)

β_v

(Tanentzapf et al., 2007, Gotwals et al., 1994)

β^vintegrin

(Gao et al., 2022)

β^ν-integrin

(Koh et al., 2004)

βInt ν

(Brown and Feder, 2005)

βInt-&ngr

(Koper et al., 2012)

βInt-ν

(Terriente-Félix et al., 2017, Carreira et al., 2011, Stofanko et al., 2010, Carreira et al., 2009, Morozova et al., 2007)

βInt^ν

βgr;-ν

(Okumura et al., 2014)

βv

(Gates, 2012, Lo, 2006, Brower, 2003, Beumer et al., 1999)

βν

(Younes et al., 2020, Park et al., 2018, Takeda et al., 2018, Nainu et al., 2017, Wood and Martin, 2017, Lin et al., 2013, Nonaka et al., 2013, Bulgakova et al., 2012, Tsai et al., 2012, Urbano et al., 2011, Tsai et al., 2008, Becam et al., 2005, Devenport and Brown, 2004, Devenport and Brown, 2004, Bokel and Brown, 2002, Brown, 2000, Brown et al., 2000, Hynes and Zhao, 2000)

Name Synonyms

Integrin

(Hughes et al., 2020)

Integrin BetaPS

(Wei et al., 2021)

Integrin betanu subunit

(Brown et al., 2013.2.5)

Integrin bn

(Kraut et al., 2001, Kraut et al., 2001)

Integrin βν subunit

(Mossman et al., 2016)

integrin beta neu

(Yee, 1993.8.26)

integrin β v

(Ramond et al., 2020, Okumura et al., 2005)

integrin βν

(Ekowati et al., 2017)

integrin βν subunit

(Brown et al., 2013.2.5)

integrinβν

(Okumura et al., 2007)

β-Integrin-ν

(Peters and Berg, 2016)

βνIntegrin

(Lee et al., 2017)

βvintegrin

(Harbison and Sehgal, 2008)

βν integrin

(Harbison and Sehgal, 2008, Morozova et al., 2007)

βv integrin

(Lo, 2006)

βν Integrin

(Kucherenko et al., 2011)

βν integrin

(Lin et al., 2013, Thimgan et al., 2013, Carreira et al., 2009, Sambandan et al., 2006)

βνintegrin

(Campbell et al., 2018)

Secondary FlyBase IDs

FBgn0010216
FBgn0025116

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35368

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q27591

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q27591

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q27591

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010395

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35368/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010395

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010395

FlyMine - An integrated database for Drosophila genomics

FBgn0010395

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1762

MARRVEL_MODEL - MARRVEL (model organism gene)

35368

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010395

DroID - A comprehensive database of gene and protein interactions.

FBgn0010395

DRSC - Results frm RNAi screens

FBgn0010395

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Itgbetanu_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010395

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010395

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1762

Flygut - An atlas of the Drosophila adult midgut

FBgn0010395

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010395

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005782

MIST (protein-protein) - An integrated Molecular Interaction Database

35368

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (122)

The following external sites may use different assemblies or annotations than FlyBase.

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