FlyBase Allele Report: Dmel\Itgbn[1]

General Information

Symbol

Dmel\Itgbn¹

Species

D. melanogaster

Name

FlyBase ID

FBal0188372

Feature type

allele

Associated gene

Dmel\Itgbn

Associated Insertion(s)

Carried in Construct

Also Known As

βν¹

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Devenport and Brown, 2004)

Progenitor genotype

P{EP}EP2030

(Devenport and Brown, 2004)

Cytology

Description

Imprecise excision of P{EP}EP2030 has produced a 1431bp deletion which includes part of P{EP} and the first 69 codons of βInt-ν.

(Devenport and Brown, 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Tsai et al., 2012)

abnormal neuroanatomy | third instar larval stage (with Itgbn²)

(Tsai et al., 2008)

fertile

(Devenport and Brown, 2004)

viable

(Devenport and Brown, 2004)

Phenotype Manifest In

embryonic/larval hemocyte

(Nagaosa et al., 2011)

neuromuscular junction | third instar larval stage (with Itgbn²)

(Tsai et al., 2008)

NMJ bouton | increased number | third instar larval stage

(Tsai et al., 2012)

NMJ bouton | increased number | third instar larval stage (with Itgbn²)

(Tsai et al., 2008)

Detailed Description

Statement

Reference

Posterior midguts from Itgbn¹ heterozygous and homozygous adults have a similar proportion of intestinal stem cells to each other and are morphologically indistinguishable from wild-type.

(Lin et al., 2013)

At 22[o]C, homozygous larvae have enlarged neuromuscular junctions (NMJs) (increased bouton number per muscle area) compared to controls. When reared at 29[o]C, the mutant larvae show no further increase in NMJ size, in contrast to wild-type controls, which show enlarged NMJs at 29[o]C compared to at 22[o]C. The mutant larvae do not show an increase in NMJ size after 8 hours food deprivation, in contrast to controls.

(Tsai et al., 2012)

Itgbn¹ mutant embryonic hemocytes show a decreased competence to undertake phagocytosis of apoptotic cells, despite of no changes in proportions of hemocytes or apoptotic cells in those embryos, as compared to controls.

(Nagaosa et al., 2011)

Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in βInt-ν¹/βInt-ν² third instar larvae.

(Tsai et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Itgbn¹/betaInt-nu[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^Mhc.PU, fz2^UAS.N

(Tsai et al., 2012)

Other

Statement

Reference

Itgbn¹/betaInt-nu[+], LanA^9-32/LanA^C01-190 has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2012)

Itgbn¹/betaInt-nu[+], LanA^9-32 has abnormal neuroanatomy | dominant | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Tsai et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Itgbn¹/Itgbn¹ is an enhancer of anterior midgut primordium phenotype of mys¹¹

(Devenport and Brown, 2004)

Itgbn¹/Itgbn¹ is an enhancer of embryonic/larval visceral muscle & midgut phenotype of mys¹¹

(Devenport and Brown, 2004)

Itgbn¹/Itgbn¹ is an enhancer of embryonic midgut constriction phenotype of mys¹¹

(Devenport and Brown, 2004)

Itgbn¹ is an enhancer of salivary gland common duct primordium | maternal effect phenotype of mys¹¹

(Devenport and Brown, 2004)

NOT Enhancer of

Statement

Reference

Itgbn¹/Itgbn¹ is a non-enhancer of circular visceral muscle primordium | maternal effect phenotype of mys¹¹

(Devenport and Brown, 2004)

Suppressor of

Statement

Reference

Itgbn¹/betaInt-nu[+] is a suppressor of neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^Mhc.PU, fz2^UAS.N

(Tsai et al., 2012)

Other

Statement

Reference

Itgbn¹/betaInt-nu[+], LanA^9-32/LanA^C01-190 has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2012)

Itgbn¹/betaInt-nu[+], LanA^9-32 has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Itgbn¹/betaInt-nu[+], LanA^9-32 has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has neuromuscular junction | third instar larval stage phenotype

(Tsai et al., 2008)

Fak^N30/Fak^KG00304, Itgbn¹/betaInt-nu[+] has NMJ bouton | increased number | third instar larval stage phenotype

(Tsai et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Adult posterior midguts from mys^M2/+; Itgbn¹/Itgbn¹ have a similar proportion of intestinal stem cells to Itgbn¹ heterozygotes and homozygotes.

(Lin et al., 2013)

βInt-ν¹/+ ; LanA^9-32/LanA^C01-190 third instar larvae show overgrowth of the neuromuscular junction.

The reduction in neuromuscular junction size seen in third instar larvae expressing fz2^Scer\UAS.N under the control of Scer\GAL4^Mhc.PU is suppressed if they are also heterozygous for βInt-ν¹.

(Tsai et al., 2012)

Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in βInt-ν¹/+ Fak^N30/Fak^KG00304 third instar larvae.

Significant overgrowth of the NMJ (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in βInt-ν¹/+ LanA^9-32/+ third instar larvae.

(Tsai et al., 2008)

Midgut constrictions fail to form in mys¹¹; βInt-ν¹ double homozygotes. This may be a secondary effect of defects in the visceral muscle surrounding the midgut: the midgut is initially enclosed by visceral muscle, but by stage 16 this muscle becomes highly disorganized and patchy and detaches from the underlying endoderm. (Note these phenotypes are for embryos maternally and zygotically βInt-ν¹/βInt-ν¹ - zygotic alone not tested). In embryos maternally and zygotically homozygous for mys¹¹ and βInt-ν¹, migration of the midgut primordia fails to occur, but disorganization of the visceral mesoderm (circular visceral muscle primordium?) seen in mys¹¹ maternal/zygotic homozygotes in not enhanced. Other mutant phenotypes of mys¹¹ mutant embryos (defects in dorsal closure, germ-band retraction and muscle detachement) are unaffected by βInt-ν¹.

(Devenport and Brown, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Itgbn¹

Itgβν¹

betaInt-nu¹

(Nagaosa et al., 2011)

β-Int ν1

(Nakano et al., 2019)

βInt-&ngr¹

(Koper et al., 2012)

βInt-ν¹

βν¹

(Lin et al., 2013, Tsai et al., 2012, Tsai et al., 2008, Becam et al., 2005, Devenport and Brown, 2004)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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