FB2024_02 , released April 23, 2024
Gene Group: TRANSCRIPTION ELONGATION FACTOR COMPLEXES
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General Information
Name
TRANSCRIPTION ELONGATION FACTOR COMPLEXES
Species
D. melanogaster
Symbol
TEFC
FlyBase ID
FBgg0001725
Date last reviewed
2021-04-15
Number of members
34
Description
Description
Transcription elongation factor complex includes various nuclear complexes that interact with RNA polymerase II and contributes to the regulation of transcription elongation. (Adapted from FBrf0246632, FBrf0211126 and FBrf0203142).
Notes on Group
Source Material
The TRANSCRIPTION ELONGATION FACTOR COMPLEXES Gene Group has been compiled using the following publication(s): Mazina et al., 2021, Nguyen et al., 2021, Goodman et al., 2019, Gerlach et al., 2017, Liu et al., 2017, Qiu and Gilmour, 2017, Hur et al., 2016, Hu et al., 2013, Rougeot et al., 2013, Katahira, 2012, Nguyen et al., 2012, Singh et al., 2011, Smith et al., 2011, Kopytova et al., 2010, Missra and Gilmour, 2010, Ardehali et al., 2009, Tsunaka et al., 2009, Smith et al., 2008, Wu et al., 2005, Lehmann, 2004, Rehwinkel et al., 2004, Shimojima et al., 2003, and Peng et al., 1998 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
regulation of transcription elongation by RNA polymerase II
Cellular Component
transcription elongation factor complex
Related Gene Groups
Component group(s)
7SK SMALL NUCLEAR RIBONUCLEOPROTEIN
DRB SENSITIVITY-INDUCING FACTOR COMPLEX
ELONGIN COMPLEX
FACT COMPLEX
LITTLE ELONGATION COMPLEX
NEGATIVE ELONGATION FACTOR
POSITIVE TRANSCRIPTION ELONGATION FACTOR COMPLEX B
RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX
SUPER ELONGATION COMPLEX
THO COMPLEX
Members (34)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
7SK SMALL NUCLEAR RIBONUCLEOPROTEIN
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bin3
bicoid-interacting protein 3
(Singh et al., 2011)
Hexim
Hexamethylene bisacetamide inducible
(Nguyen et al., 2012)
Larp7
La related protein 7
(Nguyen et al., 2012)
snRNA:7SKa
small nuclear RNA 7SK a
snmRNA:331, snRNA:7SK, 7SK, d7SK
(Nguyen et al., 2012)
snRNA:7SKb
small nuclear RNA 7SK b
(Nguyen et al., 2021)
DRB SENSITIVITY-INDUCING FACTOR COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
spt4
spt4
DSIF, Dspt4, l(2)k05316
(Qiu and Gilmour, 2017, Missra and Gilmour, 2010, Wu et al., 2005)
Spt5
Spt5
DSIF, dSpt5
(Qiu and Gilmour, 2017, Missra and Gilmour, 2010, Wu et al., 2005)
ELONGIN COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
EloA
Elongin A
dEloA
(Rougeot et al., 2013, Ardehali et al., 2009)
EloB
Elongin B
(Rougeot et al., 2013)
EloC
Elongin C
(Rougeot et al., 2013, Ardehali et al., 2009)
FACT COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
dre4
dre4
Spt16, dSPT16, l(3)dre4, l(3)62Bg
(Tsunaka et al., 2009, Lehmann, 2004, Shimojima et al., 2003)
Ssrp
Structure specific recognition protein
SSRP1, dSSRP1
(Tsunaka et al., 2009, Lehmann, 2004, Shimojima et al., 2003)
LITTLE ELONGATION COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Eaf
ELL-associated factor
dEaf
(Smith et al., 2011)
Ice1
Interacts with the C terminus of ELL 1
(Hu et al., 2013, Smith et al., 2011)
Ice2
Interacts with the C terminus of ELL 2
(Smith et al., 2011)
Su(Tpl)
Suppressor of Triplolethal
dELL, ELL, l(3)76BDs, SR3-4A, SY3-1
(Hu et al., 2013, Smith et al., 2011)
NEGATIVE ELONGATION FACTOR
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Nelf-A
Negative elongation factor A
NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
NELF-B
NELF-B
NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
Nelf-E
Negative elongation factor E
NELF, anon-66Da, NelfE
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
TH1
TH1
NELF-D, NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
POSITIVE TRANSCRIPTION ELONGATION FACTOR COMPLEX B
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cdk9
Cyclin-dependent kinase 9
P-TEFb, Positive transcription elongation factor b
(Peng et al., 1998)
CycT
Cyclin T
P-TEFb, Dmcyclin T
(Peng et al., 1998)
RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
atms
antimeros
Paf1, l(3)01456
(Goodman et al., 2019, Gerlach et al., 2017)
Atu
Another transcription unit
l(3)s1938
(Goodman et al., 2019, Gerlach et al., 2017)
Ctr9
Ctr9
(Goodman et al., 2019, Gerlach et al., 2017)
hyx
hyrax
Cdc73, Parafibromin
(Goodman et al., 2019, Gerlach et al., 2017)
Rtf1
Rtf1
dRtf1
(Goodman et al., 2019, Gerlach et al., 2017)
SUPER ELONGATION COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Eaf
ELL-associated factor
dEaf
(Smith et al., 2011, Smith et al., 2008)
ear
ENL/AF9-related
ENL/AF-9, ENL/AF9
(Smith et al., 2011)
lilli
lilliputian
l(2)00632, Su(Raf)2A, SS2-1, l(2)23Cc, SY2-1
(Liu et al., 2017, Smith et al., 2011)
Su(Tpl)
Suppressor of Triplolethal
dELL, ELL, l(3)76BDs, SR3-4A, SY3-1
(Liu et al., 2017, Smith et al., 2011, Smith et al., 2008)
THO COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Hpr1
Hpr1
(Hur et al., 2016, Katahira, 2012, Kopytova et al., 2010, Rehwinkel et al., 2004)
tho2
tho2
(Hur et al., 2016, Katahira, 2012, Kopytova et al., 2010, Rehwinkel et al., 2004)
thoc5
thoc5
(Hur et al., 2016, Katahira, 2012, Kopytova et al., 2010, Rehwinkel et al., 2004)
thoc6
thoc6
(Hur et al., 2016, Katahira, 2012, Kopytova et al., 2010, Rehwinkel et al., 2004)
thoc7
thoc7
(Hur et al., 2016, Katahira, 2012, Kopytova et al., 2010, Rehwinkel et al., 2004)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TEFC
TRANSCRIPTION ELONGATION FACTOR COMPLEXES
Secondary FlyBase ID(s)
References (24)