FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: NEGATIVE ELONGATION FACTOR
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General Information
Name
NEGATIVE ELONGATION FACTOR
Species
D. melanogaster
Symbol
NELF
FlyBase ID
FBgg0001727
Date last reviewed
Number of members
4
Description
Description
The negative elongation factor (NELF) is a multisubunit transcription regulator complex. It binds with DRB sensitivity-inducing factor (DSIF) complex and RNA polymerase II elongation complex and induces transcriptional pausing. P-TEFb phosphorylates the repressive DSIF-NELF complex, causing NELF to dissociate from Pol II and promotes RNA polymerase II elongation. (Adapted from FBrf0211126, FBrf0203142 and FBrf0184223).
Notes on Group
Source Material
The NEGATIVE ELONGATION FACTOR Gene Group has been compiled using the following publication(s): Mazina et al., 2021, Missra and Gilmour, 2010, and Wu et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
transcription elongation factor activity
Biological Process
negative regulation of transcription elongation by RNA polymerase II
Cellular Component
NELF complex
Related Gene Groups
Parent group(s)
TRANSCRIPTION ELONGATION FACTOR COMPLEXES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Nelf-A
Negative elongation factor A
NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
NELF-B
NELF-B
NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
Nelf-E
Negative elongation factor E
NELF, anon-66Da, NelfE
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
TH1
TH1
NELF-D, NELF
(Mazina et al., 2021, Missra and Gilmour, 2010, Wu et al., 2005)
External Data
Synonyms and Secondary IDs
Synonym(s)
NELF
NEGATIVE ELONGATION FACTOR
Secondary FlyBase ID(s)
References (4)