FB2024_02 , released April 23, 2024
Gene Group - Macromolecular Complex: 7SK SMALL NUCLEAR RIBONUCLEOPROTEIN
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General Information
Name
7SK SMALL NUCLEAR RIBONUCLEOPROTEIN
Species
D. melanogaster
Symbol
7SKRNP
FlyBase ID
FBgg0001641
Date last reviewed
Number of members
5
Description
Description
7SK small nuclear ribonucleoprotein (7SK snRNP) plays a central role in RNA polymerase II elongation control by sequestering positive transcription elongation factor complex b (P-TEFb) and therefore regulating the availability of active P-TEFb. (Adapted from PMID:28431135.)
Notes on Group

The definition of 7SK snRNP components varies depending on the source definition. For the 7SK SMALL NUCLEAR RIBONUCLEOPROTEIN gene group, the definition from PMID:31467394 has been used.

Source Material
The 7SK SMALL NUCLEAR RIBONUCLEOPROTEIN Gene Group has been compiled using the following publication(s): Nguyen et al., 2021, Nguyen et al., 2012, and Singh et al., 2011 .
Key Gene Ontology (GO) terms
Molecular Function
P-TEFb complex binding
Biological Process
negative regulation of transcription elongation by RNA polymerase II
Cellular Component
7SK snRNP
Related Gene Groups
Parent group(s)
SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLES
TRANSCRIPTION ELONGATION FACTOR COMPLEXES
Protein Complex group(s)
POSITIVE TRANSCRIPTION ELONGATION FACTOR COMPLEX B
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bin3
bicoid-interacting protein 3
(Singh et al., 2011)
Hexim
Hexamethylene bisacetamide inducible
(Nguyen et al., 2012)
Larp7
La related protein 7
(Nguyen et al., 2012)
snRNA:7SKa
small nuclear RNA 7SK a
snmRNA:331, snRNA:7SK, 7SK, d7SK
(Nguyen et al., 2012)
snRNA:7SKb
small nuclear RNA 7SK b
(Nguyen et al., 2021)
External Data
Synonyms and Secondary IDs
Synonym(s)
7SKRNP
7SK SMALL NUCLEAR RIBONUCLEOPROTEIN
7SK snRNP
Secondary FlyBase ID(s)
References (4)