FB2024_03 , released June 25, 2024
Gene Group: RISC LOADING COMPLEXES
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General Information
Name
RISC LOADING COMPLEXES
Species
D. melanogaster
Symbol
RLC
FlyBase ID
FBgg0001550
Date last reviewed
2020-07-06
Number of members
6
Description
Description
RISC-loading complexes (RLC) are trimeric complexes that assemble on miRNA or siRNA duplexes consisting of an Argonaute protein, a Dicer RNA helicase and an RNA binding protein. During RISC loading, the RNA duplex is transferred to Argonaute and the other RLC components dissociate. (Adapted from FBrf0215456 and FBrf0237457.)
Notes on Group
Source Material
The RISC LOADING COMPLEXES Gene Group has been compiled using the following publication(s): Tants et al., 2017, Miyoshi et al., 2009, and Tomari et al., 2007 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
RISC complex assembly
Cellular Component
RISC-loading complex
Related Gene Groups
Component group(s)
ALTERNATIVE siRNA RISC-LOADING COMPLEX
miRNA RISC LOADING COMPLEX
siRNA RISC-LOADING COMPLEX
Protein Complex group(s)
miRNA-INDUCED SILENCING COMPLEX
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
ALTERNATIVE siRNA RISC-LOADING COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AGO2
Argonaute 2
Ago-2, dAgo2, Argonaute, DmAgo2
(Tants et al., 2017)
Dcr-2
Dicer-2
Dcr2, Dicer, dmDcr-2, dcr
(Tants et al., 2017)
loqs
loquacious
R3D1, Loqs-PD, TRBP, R3D1-S, R3D1-L
(Tants et al., 2017)
miRNA RISC LOADING COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AGO1
Argonaute-1
Ago-1, Argonaute, dAGO1, l(2)04845, MRE20
(Miyoshi et al., 2009)
Dcr-1
Dicer-1
Dicer, Dcr1
(Miyoshi et al., 2009)
loqs
loquacious
R3D1, Loqs-PD, TRBP, R3D1-S, R3D1-L
(Miyoshi et al., 2009)
siRNA RISC-LOADING COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
AGO2
Argonaute 2
Ago-2, dAgo2, Argonaute, DmAgo2
(Tomari et al., 2007)
Dcr-2
Dicer-2
Dcr2, Dicer, dmDcr-2, dcr
(Tomari et al., 2007)
r2d2
r2d2
(Tomari et al., 2007)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RLC
RISC LOADING COMPLEXES
RNA-induced silencing complex-loading complexes
Secondary FlyBase ID(s)
References (4)