FB2024_03 , released June 25, 2024
Gene Group - Macromolecular Complex: GAMMA SECRETASE COMPLEX
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General Information
Name
GAMMA SECRETASE COMPLEX
Species
D. melanogaster
Symbol
GSC
FlyBase ID
FBgg0001062
Date last reviewed
Number of members
4
Description
Description
The γ-secretase complex is an intramembrane aspartyl protease complex that cleaves transmembrane proteins. In particular, it is known for cleaving amyloid precursor protein (Appl) and Notch (N) receptor. It is essential for Notch signaling, performing the second ligand-simulated cleavage, which yields Notch intracellular domain. (Adapted from FBrf0211009).
Notes on Group
Source Material
The GAMMA SECRETASE COMPLEX Gene Group has been compiled using the following publication(s): Stempfle et al., 2010 .
Key Gene Ontology (GO) terms
Molecular Function
aspartic-type endopeptidase activity
Biological Process
Notch signaling pathway
Notch receptor processing
Cellular Component
gamma-secretase complex
Enzymatic activity
Enzyme name (EC)
3.4.23.-
Related Gene Groups
Other related group(s)
Notch Signaling Pathway Core Components
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aph-1
anterior pharynx defective 1
pen-1, l(2)23AB6, l(2)23Ag
(Stempfle et al., 2010)
Nct
Nicastrin
dNicastrin, agro, nic
(Stempfle et al., 2010)
pen-2
presenilin enhancer
(Stempfle et al., 2010)
Psn
Presenilin
PS, γ-secretase, Dps, dPsn, dPresenilin
(Stempfle et al., 2010)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
GSC
GAMMA SECRETASE COMPLEX
Gamma secretase
Intramembrane aspartyl protease gamma-secretase
γ-secretase
Secondary FlyBase ID(s)
References (2)