General Information | |||
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Term | aspartic-type endopeptidase activity | ID (Ontology) | GO:0004190 (Gene Ontology) |
Definition | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.[ ISBN:0198506732 ] | ||
Also Known As | "aspartic endopeptidase activity" | ||
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QuickGO data AmiGO data | |||
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Records annotated with this term OR any of its CHILD TERMS | |||
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records | |||
peptidase activity |__endopeptidase activity____________ |__aspartic-type peptidase activity__| aspartic-type endopeptidase activity 29 rec. |__aspartic endopeptidase activity, intramembrane cleaving 4 rec. |__aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 1 rec. |
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Is a |
endopeptidase activity aspartic-type peptidase activity |
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External Crossreferences & Linkouts | |||
EC:3.4.23.- Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" Reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)" Reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" Reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants" Reactome:R-HSA-373705 "Caspase cleavage of DCC" Reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3" Reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3" Reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4" |