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Term | gamma-secretase complex | ID (Ontology) | GO:0070765 (Gene Ontology) |
Definition | A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.[ PubMed:15286082 PubMed:15890777 PubMed:17047368 PubMed:22122073 PubMed:25565961 PubMed:28320827 PubMed:32616437 ] | ||
Also Known As | "presenilin complex" | ||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records | |||
plasma membrane |__plasma membrane protein complex__ protein-containing complex | |__catalytic complex________________| membrane protein complex | |__plasma membrane protein complex__| gamma-secretase complex 5 rec. |
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plasma membrane protein complex catalytic complex |
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