FB2024_03 , released June 25, 2024
Gene Group: NON-SELECTIVE CATION CHANNEL SUBUNITS
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General Information
Name
NON-SELECTIVE CATION CHANNEL SUBUNITS
Species
D. melanogaster
Symbol
NSCC
FlyBase ID
FBgg0000586
Date last reviewed
2016-09-26
Number of members
114
Description
Description
Non-selective cation channels are transmembrane channels that conduct a small range of cations.
Notes on Group
Source Material
The NON-SELECTIVE CATION CHANNEL SUBUNITS Gene Group has been compiled using the following publication(s): Monteil et al., 2024, Corrà et al., 2023, Dow et al., 2022, Li et al., 2022, Mier et al., 2022, Hehlert et al., 2021, Li and Montell, 2021, Guo et al., 2020, Himmel and Cox, 2020, Jin et al., 2020, Yapici, 2020, Murthy et al., 2018, Zhang et al., 2018, Elbourne et al., 2017, Gosselin-Badaroudine et al., 2016, Žarsky and Doležal, 2016, Coste et al., 2015, Dong et al., 2015, Hoskins et al., 2015, Ghezzi et al., 2014, Venkatachalam et al., 2014, Fowler and Montell, 2013, Lear et al., 2013, Zhang et al., 2013, Chorna and Hasan, 2012, Coste et al., 2012, Dupuis et al., 2012, Li et al., 2011, Zhang et al., 2011, Cooper et al., 2010, Matsuura et al., 2009, Robertson, 2009, Humphrey et al., 2007, Jones et al., 2005, Montell, 2005, Sattelle et al., 2005, Robertson et al., 2003, Voets and Nilius, 2003, Kaupp and Seifert, 2002, Nash et al., 2002, Littleton and Ganetzky, 2000, Warr et al., 2000, and Finn et al., 1998 .
Key Gene Ontology (GO) terms
Molecular Function
monoatomic cation transmembrane transporter activity
Biological Process
monoatomic cation transmembrane transport
Cellular Component
membrane
Related Gene Groups
Parent group(s)
ION CHANNELS BY CONDUCTANCE
Component group(s)
CYCLIC NUCLEOTIDE-GATED CHANNEL SUBUNITS
MPV17/PMP22 CHANNEL FAMILY
NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS
ODORANT RECEPTORS
PIEZO ION CHANNELS
POLYCYSTIN CATION CHANNEL FAMILY
ROMO1 FAMILY
SODIUM CHANNEL-LIKE CATION CHANNEL SUBUNITS
SODIUM LEAK CHANNEL COMPLEX
TMEM63 MECHANICALLY ACTIVATED ION CHANNEL SUBUNITS
TRANSIENT RECEPTOR POTENTIAL ION CHANNELS
TRANSMEMBRANE CHANNEL-LIKE FAMILY SUBUNITS
Members (114)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
CYCLIC NUCLEOTIDE-GATED CHANNEL SUBUNITS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG42260
lincRNA.378
(Kaupp and Seifert, 2002)
CngA
Cyclic nucleotide-gated ion channel subunit A
DmCNGC, Cng, Cyclic-nucleotide-gated ion channel protein
(Kaupp and Seifert, 2002, Finn et al., 1998)
CngB
Cyclic nucleotide-gated ion channel subunit B
(Kaupp and Seifert, 2002, Finn et al., 1998)
Cngl
Cyclic nucleotide-gated ion channel-like
CNG channel-like
(Kaupp and Seifert, 2002)
MPV17/PMP22 PUTATIVE MITOCHONDRIAL CHANNEL FAMILY
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG1662
(Corrà et al., 2023)
CG5906
(Corrà et al., 2023)
CG12355
(Corrà et al., 2023)
CG14777
EG:80H7.10
(Corrà et al., 2023)
CG14778
(Corrà et al., 2023)
CG32262
(Corrà et al., 2023)
CG32263
(Corrà et al., 2023)
Mpv17
Mitochondrial inner membrane protein MPV17
dMpv17
(Corrà et al., 2023)
plh
pasang lhamu
(Corrà et al., 2023)
MPV17/PMP22 PUTATIVE PEROXISOMAL CHANNEL FAMILY
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG7970
(Corrà et al., 2023)
NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
nAChRα1
nicotinic Acetylcholine Receptor α1
ALS, Dα1, nAcRalpha-96Aa, nAcRα-96Aa, nAChR
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα2
nicotinic Acetylcholine Receptor α2
Dα2, SAD, nAcRα-96Ab, nAChR, nAcRalpha-96Ab
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα3
nicotinic Acetylcholine Receptor α3
Dα3, nACRalpha-7E, nAChR, nAcRα-7E, Drosophila alpha-like subunit 3
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα4
nicotinic Acetylcholine Receptor α4
Dα4, rye, nAChR, redeye, nAcRα-80B
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα5
nicotinic Acetylcholine Receptor α5
Dα5, BG:DS05899.4, nAChR, nAcRalpha-34E, nAcRα-34E
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα6
nicotinic Acetylcholine Receptor α6
Dα6, nAcRα-30D, nAcRalpha-30D, nAChR, nicotinic Acetylcholine Receptor α 30D
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRα7
nicotinic Acetylcholine Receptor α7
Dα7, gfA, nAChR, nAcRα-18C, giant fibre A
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRβ1
nicotinic Acetylcholine Receptor β1
ARD, Dβ1, nAcRβ-64B, nAChR, nAcRbeta-64B
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRβ2
nicotinic Acetylcholine Receptor β2
SBD, Dβ2, nAcRbeta-96A, nAChR, second beta-like subunit of Drosophila
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
nAChRβ3
nicotinic Acetylcholine Receptor β3
Dβ3, nAcRβ-21C, nAChR, nAcRbeta-21C, nicotinic acetylcholine receptor beta 21C
(Dupuis et al., 2012, Sattelle et al., 2005, Littleton and Ganetzky, 2000)
ODORANT RECEPTORS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Or1a
Odorant receptor 1a
1a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or2a
Odorant receptor 2a
EG:30B8.7, AN4, Olfactory receptor 2F.1
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or7a
Odorant receptor 7a
7a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or9a
Odorant receptor 9a
DmOr9a, 9a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or10a
Odorant receptor 10a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or13a
Odorant receptor 13a
13a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or19a
Odorant receptor 19a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or19b
Odorant receptor 19b
(Mier et al., 2022, Robertson et al., 2003)
Or22a
Odorant receptor 22a
AN11, DOR22a, Dor53, 22A.1, DmOr22a
(Mier et al., 2022, Robertson, 2009, Jones et al., 2005, Robertson et al., 2003, Warr et al., 2000)
Or22b
Odorant receptor 22b
AN12, 22A.2, DOR22A.2, Dor67
(Mier et al., 2022, Robertson, 2009, Jones et al., 2005, Robertson et al., 2003, Warr et al., 2000)
Or22c
Odorant receptor 22c
22c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or23a
Odorant receptor 23a
AN5, DOR64
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or24a
Odorant receptor 24a
Or24D.1, 24a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or30a
Odorant receptor 30a
30a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or33a
Odorant receptor 33a
AN3
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or33b
Odorant receptor 33b
AN1, 33b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or33c
Odorant receptor 33c
AN2
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or35a
Odorant receptor 35a
BG:BACR44L22.5, 35a
(Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or42a
Odorant receptor 42a
42a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or42b
Odorant receptor 42b
42b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or43a
Odorant receptor 43a
DOR87, AN14
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or43b
Odorant receptor 43b
AN7, 43b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or45a
Odorant receptor 45a
45a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or45b
Odorant receptor 45b
45b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or46a
Odorant receptor 46a
Or46aA, Or46aB, Or46b, AN9, AN8
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or47a
Odorant receptor 47a
AN10, DOR24, 47a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or47b
Odorant receptor 47b
Or47E.2
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or49a
Odorant receptor 49a
49a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or49b
Odorant receptor 49b
AN13
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or56a
Odorant receptor 56a
56a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or59a
Odorant receptor 59a
AN6, 59a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or59b
Odorant receptor 59b
DmOr59b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or59c
Odorant receptor 59c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or63a
Odorant receptor 63a
63a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or65a
Odorant receptor 65a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or65b
Odorant receptor 65b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or65c
Odorant receptor 65c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or67a
Odorant receptor 67a
67a, DmOr67a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or67b
Odorant receptor 67b
67b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or67c
Odorant receptor 67c
67c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or67d
Odorant receptor 67d
DmOr67d
(Mier et al., 2022, Robertson et al., 2003)
Or69a
Odorant receptor 69a
Or69aA, Or69aB, Or69b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or71a
Odorant receptor 71a
Or71c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or74a
Odorant receptor 74a
74a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or82a
Odorant receptor 82a
82a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or83a
Odorant receptor 83a
83a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or83c
Odorant receptor 83c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85a
Odorant receptor 85a
85a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85b
Odorant receptor 85b
DmOr85b, 85b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85c
Odorant receptor 85c
85c
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85d
Odorant receptor 85d
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85e
Odorant receptor 85e
Odorant receptor 104, Dor104
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or85f
Odorant receptor 85f
85f, DmOr85f
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or88a
Odorant receptor 88a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or92a
Odorant receptor 92a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or94a
Odorant receptor 94a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or94b
Odorant receptor 94b
94b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or98a
Odorant receptor 98a
98a
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Or98b
Odorant receptor 98b
(Mier et al., 2022, Robertson, 2009, Robertson et al., 2003, Warr et al., 2000)
Orco
Odorant receptor co-receptor
Or83b
(Mier et al., 2022, Robertson, 2009, Jones et al., 2005, Robertson et al., 2003, Warr et al., 2000)
PIEZO ION CHANNELS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Piezo
Piezo
Dmpiezo
(Hehlert et al., 2021, Jin et al., 2020, Coste et al., 2015, Coste et al., 2012)
Pzl
Piezo-like
(Hoskins et al., 2015)
POLYCYSTIN CATION CHANNEL FAMILY
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
brv1
brivido-1
(Elbourne et al., 2017)
brv2
brivido-2
Brv-2
(Elbourne et al., 2017)
brv3
brivido-3
EG:BACR7C10.7, Brv-3
(Elbourne et al., 2017)
CG30048
(Dow et al., 2022, Elbourne et al., 2017)
CG42685
DS07721.6-like protein, BG:DS07721.6
(Elbourne et al., 2017)
Pkd2
Polycystic kidney disease 2
amo, Almost there, Polycystic kidney disease gene-2, TRPP2, Dmpkd2
(Dow et al., 2022, Elbourne et al., 2017)
PRY
polycystine-related-Y
(Hoskins et al., 2015)
ROMO1 FAMILY
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG6878
Romo1
(Žarsky and Doležal, 2016)
SODIUM CHANNEL-LIKE CATION CHANNEL SUBUNITS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
NaCP60E
Na channel protein 60E
DSC1, smi60E, DSC, Na-CP
(Gosselin-Badaroudine et al., 2016, Dong et al., 2015, Zhang et al., 2013, Li et al., 2011, Zhang et al., 2011)
SODIUM LEAK CHANNEL COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Mid1
Mid1
Nlf-1
(Monteil et al., 2024, Ghezzi et al., 2014)
na
narrow abdomen
har38, har, NALCN, har85
(Monteil et al., 2024, Ghezzi et al., 2014, Lear et al., 2013, Humphrey et al., 2007, Nash et al., 2002)
unc79
uncoordinated 79
dunc79
(Monteil et al., 2024, Ghezzi et al., 2014, Lear et al., 2013, Humphrey et al., 2007)
unc80
uncoordinated 80
(Monteil et al., 2024, Ghezzi et al., 2014, Lear et al., 2013)
TMEM63 MECHANICALLY ACTIVATED ION CHANNEL SUBUNITS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Tmem63
Transmembrane protein 63
(Li et al., 2022, Hehlert et al., 2021, Li and Montell, 2021, Jin et al., 2020, Murthy et al., 2018)
TRANSIENT RECEPTOR POTENTIAL ION CHANNELS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
brv1
brivido-1
(Himmel and Cox, 2020, Zhang et al., 2018, Littleton and Ganetzky, 2000)
brv2
brivido-2
Brv-2
(Himmel and Cox, 2020, Littleton and Ganetzky, 2000)
brv3
brivido-3
EG:BACR7C10.7, Brv-3
(Himmel and Cox, 2020, Littleton and Ganetzky, 2000)
CG42638
noncoding_13567
(Cooper et al., 2010)
iav
inactive
TRPV
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
nan
nanchung
TRPV
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005)
nompC
no mechanoreceptor potential C
TRPN, TRPN1, jf24, l(2)jf24
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Voets and Nilius, 2003, Littleton and Ganetzky, 2000)
pain
painless
EP2251
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
Pkd2
Polycystic kidney disease 2
amo, Almost there, Polycystic kidney disease gene-2, TRPP2, Dmpkd2
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
pyx
pyrexia
dTRPA2
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
trp
transient receptor potential
559, dTRP, DmTRP
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Voets and Nilius, 2003, Littleton and Ganetzky, 2000)
TrpA1
Transient receptor potential cation channel A1
dTrpA1, dANKTM1, DmTRPA1, TrpA, Transient receptor potential A1
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
Trpγ
Transient receptor potential cation channel γ
trp-γ
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005)
trpl
transient receptor potential-like
trp-like, DmTRPL, trp-l
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005, Voets and Nilius, 2003, Littleton and Ganetzky, 2000)
Trpm
Transient receptor potential cation channel, subfamily M
dTRPM
(Himmel and Cox, 2020, Venkatachalam et al., 2014, Fowler and Montell, 2013, Chorna and Hasan, 2012, Matsuura et al., 2009, Montell, 2005)
Trpml
Transient receptor potential cation channel, mucolipin
l(3)76BDi, transient receptor potential mucolipin
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
wtrw
water witch
dTRPA3
(Venkatachalam et al., 2014, Fowler and Montell, 2013, Matsuura et al., 2009, Montell, 2005, Littleton and Ganetzky, 2000)
TRANSMEMBRANE CHANNEL-LIKE FAMILY SUBUNITS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Tmc
Transmembrane channel-like
(Hehlert et al., 2021, Guo et al., 2020, Jin et al., 2020, Yapici, 2020)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
NSCC
NON-SELECTIVE CATION CHANNEL SUBUNITS
Secondary FlyBase ID(s)
References (44)