FB2024_04 , released June 25, 2024
Gene: Dmel\Orco
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General Information
Symbol
Dmel\Orco
Species
D. melanogaster
Name
Odorant receptor co-receptor
Annotation Symbol
CG10609
Feature Type
protein_coding_gene
FlyBase ID
FBgn0037324
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Odorant receptor co-receptor (Orco) encodes a broadly expressed in the chemosensory organs, where it forms heteromultimeric complexes with ligand-selective odorant receptors (ORs). It serves dual role as a chaperone for cell surface expression of the OR/Orco complex as well as being integral to the function of the olfactory receptor complex. It does not itself respond to olfactory ligands, but is thought to contribute to the putative ion-conducting pore. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Or83b

Key Links
Genomic Location
Cytogenetic map
83A2-83A2
Sequence location
Recombination map
3-47.5
RefSeq locus
NT_033777 REGION:5407183..5412406
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
enables calmodulin binding
inferred from mutant phenotype
(Mukunda et al., 2014)
enables coreceptor activity
inferred from mutant phenotype
(Carraher et al., 2015)
enables intracellularly gated calcium channel activity
inferred from direct assay
(Mukunda et al., 2014)
contributes_to ionotropic olfactory receptor activity
inferred from direct assay
(Nichols and Luetje, 2010)
inferred from genetic interaction with FLYBASE:Or22b; FB:FBgn0026397,FLYBASE:Or22a; FB:FBgn0026398
(Carraher et al., 2015)
enables ionotropic olfactory receptor activity
inferred from direct assay
(Mukunda et al., 2014)
enables odorant binding
inferred from physical interaction with FLYBASE:Or67a; FB:FBgn0036009
(Tegler et al., 2015)
inferred from physical interaction with FLYBASE:Or85b; FB:FBgn0037590
(Tegler et al., 2015)
enables olfactory receptor activity
inferred from direct assay
(Benton et al., 2006)
enables protein homodimerization activity
inferred from physical interaction with FLYBASE:Orco; FB:FBgn0037324
(Benton et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables calmodulin binding
inferred from sequence model
(Mukunda et al., 2014)
enables odorant binding
inferred from electronic annotation with InterPro:IPR004117
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:Or43b; FB:FBgn0026393
(Gene Ontology Curators, 2002-)
enables olfactory receptor activity
inferred from electronic annotation with InterPro:IPR004117
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in behavioral response to ethanol
inferred from mutant phenotype
(Kong et al., 2010)
involved_in detection of chemical stimulus involved in sensory perception of smell
inferred from direct assay
(Mukunda et al., 2014, Nichols and Luetje, 2010)
inferred from mutant phenotype
(Carraher et al., 2015, Ronderos et al., 2014)
involved_in olfactory behavior
inferred from mutant phenotype
(Lee et al., 2017, Fishilevich et al., 2005, Larsson et al., 2004)
involved_in regulation of protein localization
inferred from mutant phenotype
(Ha et al., 2014)
involved_in response to pheromone
inferred from mutant phenotype
(Jin et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in detection of chemical stimulus involved in sensory perception of smell
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(GO Reference Genome Project, 2011-)
involved_in sensory perception of smell
inferred from electronic annotation with InterPro:IPR004117
(InterPro Project Members, 2004-)
traceable author statement
(Keller and Vosshall, 2003)
non-traceable author statement
(Carlson, 2001)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
part_of cation channel complex
inferred from direct assay
(Nichols and Luetje, 2010)
colocalizes_with cilium
inferred from direct assay
(Ha et al., 2014)
located_in cilium
inferred from direct assay
(Kuzhandaivel et al., 2014)
located_in dendrite
inferred from direct assay
(Bahk and Jones, 2016, Benton et al., 2006)
inferred from mutant phenotype
(Carraher et al., 2015)
is_active_in plasma membrane
inferred from direct assay
(Nichols and Luetje, 2010)
located_in plasma membrane
inferred from direct assay
(Benton et al., 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of cation channel complex
traceable author statement
(Carraher et al., 2015)
located_in dendrite membrane
inferred from sequence or structural similarity with FLYBASE:Or22a; FB:FBgn0026398
(Gene Ontology Curators, 2002-)
located_in membrane
inferred from electronic annotation with InterPro:IPR004117
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred by curator from GO:0170020
(Carraher et al., 2015)
inferred from biological aspect of ancestor with PANTHER:PTN000474402
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily. (Q9VNB5)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Odorant receptor co-receptor (Orco) encodes a broadly expressed in the chemosensory organs, where it forms heteromultimeric complexes with ligand-selective odorant receptors (ORs). It serves dual role as a chaperone for cell surface expression of the OR/Orco complex as well as being integral to the function of the olfactory receptor complex. It does not itself respond to olfactory ligands, but is thought to contribute to the putative ion-conducting pore. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
ODORANT RECEPTORS -
Insect odorant receptors (ORs) are a family of chemoreceptors activated by volatile chemicals. ORs form heteromeric complexes, believed to function as non-selective cation channels, comprising an OR and the co-receptor Orco. ORs are expressed in the dendrites of subsets of olfactory neurons in the antenna and maxillary palp. (Adapted from FBrf0168007 and FBrf0220463).
Protein Function (UniProtKB)
Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.
(UniProt, Q9VNB5)
Summary (Interactive Fly)

7 TM odorant receptor - broadly expressed receptor of unknown function - required for dendritic localization of conventional odorant receptors - mutation disrupts behavioral and electorphysiological responses to many odorants

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Orco for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VNB5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model as per FBrf0136024

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Orco-RA
FBtr0078794
NM_079511
1929
486
Orco-RB
FBtr0113193
NM_001104217
1743
486
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Orco-PA
FBpp0078438
54.4
486
8.65
Q9VNB5
NP_524235
AAF52031
Orco-PB
FBpp0112105
54.4
486
8.65
Q9VNB5
NP_001097687
ABW08603
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

486 aa isoforms: Orco-PA, Orco-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.

(UniProt, Q9VNB5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orco using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron of antennal coeloconic sensillum ac3
(Benton et al., 2009)
neuron of basiconic sensillum of antennal segment 3
(Benton et al., 2009)
neuron of trichoid sensillum of antennal segment 3
(Benton et al., 2009)
third segment of antenna
(Neuhaus et al., 2005)
antenna
(Benton et al., 2007)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
antenna
(Croset et al., 2010)
Additional Descriptive Data

Orco transcript is observed in the neurons of the basiconicum, trichodeum and coeloconic sensilla ac3 of the third segment of the antenna. In sensillum ac3 it is co-expressed with Ir75a, Ir75b, Or35a and Ir76b.

(Benton et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
embryonic/larval olfactory receptor neuron
(Prieto-Godino et al., 2012)
adult stage
antenna
(Benton et al., 2007)
sensory neuron of trichoid sensillum
(Benton et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of cation channel complex
inferred from direct assay
(Nichols and Luetje, 2010)
colocalizes_with cilium
inferred from direct assay
(Ha et al., 2014)
located_in cilium
inferred from direct assay
(Kuzhandaivel et al., 2014)
located_in dendrite
inferred from direct assay
(Bahk and Jones, 2016, Benton et al., 2006)
inferred from mutant phenotype
(Carraher et al., 2015)
is_active_in plasma membrane
inferred from direct assay
(Nichols and Luetje, 2010)
located_in plasma membrane
inferred from direct assay
(Benton et al., 2006)
Expression Deduced from Reporters
Reporter: P{Orco-GAL4.7.087}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
olfactory receptor neuron of maxillary palp | subset
(Yu et al., 2004)
antenna
(Hallem et al., 2004, Yu et al., 2004)
olfactory receptor neuron of maxillary palp
(Hallem et al., 2004)
olfactory receptor neuron of antenna | subset
(Yu et al., 2004)
olfactory receptor neuron of antenna
(Hallem et al., 2004)
maxillary palp
(Hallem et al., 2004, Yu et al., 2004)
olfactory receptor neuron | subset
(Hallem et al., 2004, Yu et al., 2004, Ng et al., 2002)
maxillary palp olfactory receptor neuron | subset
(Hallem et al., 2004)
adult antennal olfactory receptor neuron | subset
(Hallem et al., 2004)
adult antennal lobe glomerulus | subset
(Yu et al., 2004, Ng et al., 2002)
Reporter: P{Orco-GAL4.C}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
neuron | subset of adult brain
(Chen et al., 2012)
olfactory receptor neuron

Comment: strong expression

(Chen et al., 2012)
Reporter: P{Orco-GAL4.K}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
olfactory receptor neuron
(Kreher et al., 2005)
larval stage -- adult stage
olfactory receptor neuron
(Deng et al., 2011)
adult stage
adult olfactory receptor neuron | subset
(Zhang et al., 2020)
Reporter: P{Orco-GAL4.T:Hsim\VP16}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
olfactory receptor neuron | subset
(Kalidas and Smith, 2002)
Reporter: P{Orco-GAL4.W}
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval olfactory receptor neuron | restricted
(Masuda-Nakagawa et al., 2009)
adult stage
olfactory receptor neuron of basiconic sensillum of antennal segment 3 | subset
(Tanoue et al., 2004)
olfactory receptor neuron of maxillary palp basiconic sensillum | subset
(Tanoue et al., 2004)
maxillary palp basiconic sensillum | subset
(Tanoue et al., 2004)
olfactory receptor neuron | subset
(Root et al., 2008, Suh et al., 2004, Tanoue et al., 2004, Wang et al., 2003)
basiconic sensillum of antennal segment 3 | subset
(Tanoue et al., 2004)
adult olfactory receptor neuron | subset
(Shang et al., 2007, Suh et al., 2004)
adult olfactory receptor neuron Or22
(Ronderos et al., 2014, Shang et al., 2007)
adult olfactory receptor neuron Or47a
(Shang et al., 2007)
adult olfactory receptor neuron Or92a
(Shang et al., 2007)
adult olfactory receptor neuron
(Kain et al., 2008, Lai and Lee, 2006)
antenna | restricted
(Kain et al., 2008, Root et al., 2008)
third segment of antenna | restricted
(Kain et al., 2008)
maxillary palp | restricted
(Root et al., 2008)
adult antennal lobe | restricted
(Root et al., 2008)
adult antennal lobe glomerulus | subset
(Wang et al., 2003)
adult antennal lobe glomerulus
(Lai and Lee, 2006)
Reporter: P{Orco-LexA-VP16}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
embryonic/larval olfactory receptor neuron

Comment: 21h AEL

(Prieto-Godino et al., 2012)
adult stage
antenna | restricted
(Root et al., 2008)
maxillary palp | restricted
(Root et al., 2008)
olfactory receptor neuron | subset
(Root et al., 2008)
adult olfactory receptor neuron
(Gordon and Scott, 2009, Lai and Lee, 2006)
adult antennal lobe | restricted
(Root et al., 2008)
adult olfactory receptor neuron | subset
(Coates et al., 2017)
adult antennal lobe glomerulus
(Lai and Lee, 2006)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Orco in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Orco
Transgenic constructs containing regulatory region of Orco
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel9029
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal behavior | male
abnormal chemosensory behavior, with Orco2/Orco1, Scer\GAL4Or42b.PF
abnormal chemosensory behavior (with Orco1)
abnormal chemosensory behavior (with Orco1), with OrcoUAS.GFP, Scer\GAL4Or42b.PF
abnormal chemosensory behavior (with Orco2)
abnormal chemosensory behavior (with Orco2), with OrcoUAS.GFP, Scer\GAL4Or42b.PF
abnormal chemosensory behavior | adult stage
abnormal chemosensory behavior | adult stage (with Df(3R)ED5156)
abnormal chemosensory behavior | adult stage (with Orco1)
abnormal chemosensory behavior | adult stage (with Orco2)
abnormal chemosensory behavior | larval stage
abnormal locomotor behavior
abnormal locomotor behavior | larval stage
abnormal mating rhythm
abnormal neurophysiology
abnormal neurophysiology (with Orco1)
abnormal neurophysiology (with Orco2)
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage, with Orco2, Scer\GAL4Orco.2.642.Hsim\VP22
abnormal neurophysiology | adult stage, with OrcoS289A.UAS, Scer\GAL4Orco.2.642.Hsim\VP22
abnormal neurophysiology | adult stage | conditional
abnormal neurophysiology | embryonic stage
abnormal neurophysiology | first instar larval stage
abnormal smell perception
abnormal smell perception, with Orco1, Scer\GAL4Or42a.PF
abnormal smell perception, with Orco2/Orco1, Scer\GAL4Or42a.PF
abnormal smell perception, with OrcoUAS.cLa, Scer\GAL4Or42a.PF
abnormal smell perception (with Orco1)
abnormal smell perception (with Orco1), with OrcoUAS.cLa, Scer\GAL4Or42a.PF
abnormal smell perception (with Orco1), with OrcoUAS.GFP, Scer\GAL4Or42a.PF
abnormal smell perception (with Orco2)
abnormal smell perception (with Orco2), with OrcoUAS.cLa, Scer\GAL4Or42a.PF
abnormal smell perception (with Orco2), with OrcoUAS.GFP, Scer\GAL4Or42a.PF
abnormal smell perception | adult stage
abnormal smell perception | dominant | female
chemical resistant | conditional
chemical sensitive | conditional
decreased rate of movement | conditional
increased rate of movement | conditional
long lived | female
long lived | male
Phenotype manifest in
Allele
adult lateral horn type II neuron
adult olfactory receptor neuron
adult olfactory receptor neuron Or22 | conditional
adult olfactory receptor neuron Or67d, with Orco2, Scer\GAL4Orco.2.642.Hsim\VP22
adult olfactory receptor neuron Or67d, with OrcoS289A.UAS, Scer\GAL4Orco.2.642.Hsim\VP22
antenna
antennal intermediate sensillum ai2
antennal sense organ
embryonic/larval olfactory receptor neuron
olfactory receptor neuron (with Orco1)
olfactory receptor neuron (with Orco2)
olfactory receptor neuron | adult stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (69)
Agam\OR7_ANOGA
11 of 12
Yes
Yes
Agam\AgaP_AGAP003055
1 of 12
No
No
Agam\AgaP_AGAP005495
1 of 12
No
No
Agam\AgaP_AGAP009411
1 of 12
No
No
Agam\AgaP_AGAP012854
1 of 12
No
No
Agam\AgaP_AGAP013396
1 of 12
No
No
Agam\GPROR3
1 of 12
No
No
Agam\GPROR4
1 of 12
No
No
Agam\GPROR5
1 of 12
No
No
Agam\GPROR6
1 of 12
No
No
Agam\GPROR8
1 of 12
No
No
Agam\GPROR9
1 of 12
No
No
Agam\GPROR10
1 of 12
No
No
Agam\GPROR11
1 of 12
No
No
Agam\GPROR12
1 of 12
No
No
Agam\GPROR13
1 of 12
No
No
Agam\GPROR14
1 of 12
No
No
Agam\GPROR15
1 of 12
No
No
Agam\GPROR16
1 of 12
No
No
Agam\GPROR17
1 of 12
No
No
Agam\GPROR18
1 of 12
No
No
Agam\GPROR20
1 of 12
No
No
Agam\GPROR22
1 of 12
No
No
Agam\GPROR23
1 of 12
No
No
Agam\GPROR25
1 of 12
No
No
Agam\GPROR26
1 of 12
No
No
Agam\GPROR27
1 of 12
No
No
Agam\GPROR28
1 of 12
No
No
Agam\GPROR29
1 of 12
No
No
Agam\GPROR30
1 of 12
No
No
Agam\GPROR31
1 of 12
No
No
Agam\GPROR32
1 of 12
No
No
Agam\GPROR33
1 of 12
No
No
Agam\GPROR34
1 of 12
No
No
Agam\GPROR35
1 of 12
No
No
Agam\GPROR37
1 of 12
No
No
Agam\GPROR38
1 of 12
No
No
Agam\GPROR39
1 of 12
No
No
Agam\GPROR40
1 of 12
No
No
Agam\GPROR41
1 of 12
No
No
Agam\GPROR42
1 of 12
No
No
Agam\GPROR43
1 of 12
No
No
Agam\GPROR44
1 of 12
No
No
Agam\GPROR45
1 of 12
No
No
Agam\GPROR46
1 of 12
No
No
Agam\GPROR47
1 of 12
No
No
Agam\GPROR48
1 of 12
No
No
Agam\GPROR49
1 of 12
No
No
Agam\GPROR51
1 of 12
No
No
Agam\GPROR52
1 of 12
No
No
Agam\GPROR53
1 of 12
No
No
Agam\GPROR55
1 of 12
No
No
Agam\GPROR56
1 of 12
No
No
Agam\GPROR57
1 of 12
No
No
Agam\GPROR59
1 of 12
No
Yes
Agam\GPROR61
1 of 12
No
Yes
Agam\GPROR63
1 of 12
No
No
Agam\GPROR65
1 of 12
No
No
Agam\GPROR66
1 of 12
No
No
Agam\GPROR68
1 of 12
No
No
Agam\GPROR69
1 of 12
No
No
Agam\GPROR70
1 of 12
No
No
Agam\GPROR71
1 of 12
No
No
Agam\GPROR72
1 of 12
No
No
Agam\GPROR73
1 of 12
No
No
Agam\GPROR74
1 of 12
No
No
Agam\GPROR77
1 of 12
No
No
Agam\OR1_ANOGA
1 of 12
No
No
Agam\OR2_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Orco. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (59)
Or1a
2 of 13
Or2a
2 of 13
Or7a
2 of 13
Or9a
2 of 13
Or10a
2 of 13
Or13a
2 of 13
Or19a
2 of 13
Or19b
2 of 13
Or22a
2 of 13
Or22b
2 of 13
Or22c
2 of 13
Or23a
2 of 13
Or24a
2 of 13
Or30a
2 of 13
Or33a
2 of 13
Or33b
2 of 13
Or33c
2 of 13
Or42a
2 of 13
Or42b
2 of 13
Or43a
2 of 13
Or43b
2 of 13
Or45a
2 of 13
Or45b
2 of 13
Or46a
2 of 13
Or47a
2 of 13
Or47b
2 of 13
Or49a
2 of 13
Or49b
2 of 13
Or56a
2 of 13
Or59a
2 of 13
Or59b
2 of 13
Or59c
2 of 13
Or63a
2 of 13
Or65a
2 of 13
Or65b
2 of 13
Or65c
2 of 13
Or67a
2 of 13
Or67c
2 of 13
Or69a
2 of 13
Or71a
2 of 13
Or74a
2 of 13
Or82a
2 of 13
Or83a
2 of 13
Or83c
2 of 13
Or85a
2 of 13
Or85b
2 of 13
Or85c
2 of 13
Or85d
2 of 13
Or85e
2 of 13
Or85f
2 of 13
Or88a
2 of 13
Or92a
2 of 13
Or94a
2 of 13
Or94b
2 of 13
Or98a
2 of 13
Or98b
2 of 13
Or35a
1 of 13
Or67b
1 of 13
Or67d
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Orco1
    DOES NOT model  alcohol use disorder
    CEA
    (Kong et al., 2010)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Orco
    suppressible
    Ir8a
    (Silbering et al., 2011)
    Orco
    suppressible
    Or83c
    (Ronderos et al., 2014)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    shop
    enhanceable
    Orco
    (Otto et al., 2018)
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
    (UniProt, Q9VNB5 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-47.5
    Cytogenetic map
    83A2-83A2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    83A2-83A2
    Limits computationally determined from genome sequence between P{EP}EP974 and P{PZ}Snr101319&P{PZ}Itp-r83A05616
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-47.5

    (FlyBase, 2016)

    3-44.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (16)
    Genomic Clones (28)
    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Pacalon et al., 2023, Guo et al., 2017)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          The Or83b product is required to maintain odorant receptor localization and stability.

          (Benton et al., 2006)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: Or83b CG10609

          (Warr and Vosshall, 2000.5.19)

          Source for identity of: Orco Or83b

          (Vosshall and Hansson, 2011.1.24)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (27)
          Reported As
          Symbol Synonym
          83A.2
          (Warr and Vosshall, 2000.5.19)
          83b
          (Vogt et al., 2002)
          A45
          CG10609
          (Meadows, 2017.1.11, Keleman et al., 2009.8.5, Ni et al., 2009, Perkins et al., 2009, Robertson, 2009, Ni et al., 2008)
          DOR45
          (Warr and Vosshall, 2000.5.19)
          DOR83b
          (Neuhaus et al., 2005)
          DmORCO
          (Tegler et al., 2015)
          DmOrco
          (Romaine et al., 2014)
          DmelOrco
          (Kumar et al., 2013)
          OR49
          (Nozawa and Nei, 2007)
          OR83B
          (Ni et al., 2009)
          OR83b
          (Das et al., 2019, Fulterer et al., 2018, Ziegler et al., 2013, Harini and Sowdhamini, 2012, Jones and Grotewiel, 2011, Störtkuhl and Fiala, 2011, Croset et al., 2010, Nichols and Luetje, 2010, Benton et al., 2009, Rhodenizer et al., 2008, Libert, 2007, Lundin et al., 2007, Nozawa and Nei, 2007, Benton et al., 2006, Gross, 2006, Stocker, 2006, Kalidas and Smith, 2002, Kalidas et al., 2001)
          ORCO
          (Gaspar et al., 2022, Montell, 2021, Ono et al., 2021, Jiang et al., 2020, Schmidt and Benton, 2020, Fulterer et al., 2018, Gomez-Diaz et al., 2018, Fischer et al., 2017, Ramdya et al., 2015, Ai et al., 2013, Gomez-Diaz et al., 2013, Min et al., 2013)
          Or83b
          (Zhao et al., 2024, Miller et al., 2020, Ping et al., 2020, Brankatschk et al., 2018, Ganguly et al., 2017, Lone et al., 2016, Murmu and Martin, 2016, Dekker et al., 2015, Del Pino et al., 2015, Sujkowski et al., 2015, Chi et al., 2014, Dipt et al., 2014, Gendron et al., 2014, Honda et al., 2014, Krstic et al., 2013, Leal, 2013, Billeter et al., 2012, Immonen and Ritchie, 2012, Jeong et al., 2012, Linford et al., 2012, Lone and Sharma, 2012, Prieto-Godino et al., 2012, Simon et al., 2012, Deng et al., 2011, Franco et al., 2011, Kazama et al., 2011, Lone and Sharma, 2011, Lone and Sharma, 2011, Niewalda et al., 2011, Störtkuhl and Fiala, 2011, Bellmann et al., 2010, Bhandawat et al., 2010, Foley et al., 2010, Kong et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Larkin et al., 2010, Lee et al., 2010, Mishra et al., 2010, Miyazaki and Ito, 2010, Poon et al., 2010, Wang and Anderson, 2010, Yao and Carlson, 2010, Asahina et al., 2009, Chiang et al., 2009, Krstic et al., 2009, Masuda-Nakagawa et al., 2009, Robertson, 2009, Zhou et al., 2009, Asahina et al., 2008, DasGupta and Waddell, 2008, Ditzen et al., 2008, Hiroi et al., 2008, Hoare et al., 2008, Huang et al., 2008, Jin et al., 2008, Krishnan et al., 2008, Louis et al., 2008, Olsen and Wilson, 2008, Poon et al., 2008, Sambandan et al., 2008, Sato et al., 2008, Smart et al., 2008, Wicher et al., 2008, Benton et al., 2007, Benton et al., 2007, Fujii et al., 2007, Grillenzoni et al., 2007, Guo and Kim, 2007, Jones et al., 2007, Kwon et al., 2007, Leslie, 2007, Libert et al., 2007, McBride et al., 2007, Olsen et al., 2007, Sachse et al., 2007, Bargmann, 2006, de Bruyne and Warr, 2006, Kamikouchi et al., 2006, Lai and Lee, 2006, Morozova et al., 2006, van der Goes van Naters and Carlson, 2006, Jones et al., 2005, Kreher et al., 2005, Sen et al., 2005, Robertson et al., 2003)
          OrCo
          (Fischer et al., 2017)
          Orco
          (Sadanandappa and Bosco, 2024, Ali et al., 2023, Ha et al., 2023, Lee et al., 2023, Song et al., 2023, Walker et al., 2023, Ali et al., 2022, Deshpande et al., 2022, Eickelberg et al., 2022, Guo and Smith, 2022, He et al., 2022, Kleinheinz et al., 2022, Komarov and Sprecher, 2022, Koranteng et al., 2022, Li et al., 2022, Mier et al., 2022, Pang et al., 2022, Tumkaya et al., 2022, Wiesel et al., 2022, Yang and Zhang, 2022, Zocchi et al., 2022, Cai et al., 2021, Gao et al., 2021, He et al., 2021, Ishimoto and Kamikouchi, 2021, Jafari and Alenius, 2021, Jana et al., 2021, Kolesov et al., 2021, McLaughlin et al., 2021, Mika and Benton, 2021, Montanari and Royet, 2021, Sadanandappa et al., 2021, Task and Potter, 2021, Vogt et al., 2021, Wang et al., 2021, Brenman-Suttner et al., 2020, Guo et al., 2020, Lucke et al., 2020, Miller et al., 2020, Slankster et al., 2020, Sun et al., 2020, Wolterhoff et al., 2020, Batra et al., 2019, Chai et al., 2019, Chakraborty et al., 2019, Kacsoh et al., 2019, Kadakia and Emonet, 2019, Li et al., 2019, Li et al., 2019, Miazzi et al., 2019, Narasimha et al., 2019, Qiao et al., 2019, Rivera et al., 2019, Si et al., 2019, Abu et al., 2018, Alisch et al., 2018, Chin et al., 2018, Halty-deLeon et al., 2018, Jung et al., 2018, Landayan et al., 2018, MacWilliam et al., 2018, Rode et al., 2018, Utashiro et al., 2018, Watanabe et al., 2018, Yu et al., 2018, Cao et al., 2017, Croft et al., 2017, Giang et al., 2017, Guo et al., 2017, Keita et al., 2017, Kim and Dickinson, 2017, Ramdya et al., 2017, Retzke et al., 2017, Bahk and Jones, 2016, Corrales-Carvajal et al., 2016, Dubey et al., 2016, Dweck et al., 2016, Enjin et al., 2016, Getahun et al., 2016, Grabe et al., 2016, Hussain et al., 2016, Newquist et al., 2016, Sarov et al., 2016, Dekker et al., 2015, Del Pino et al., 2015, Dweck et al., 2015, Grotewiel and Bettinger, 2015, Lin et al., 2015, Liu et al., 2015, Proshkina et al., 2015, Slepian et al., 2015, Del Pino et al., 2014, Fişek and Wilson, 2014, Gomez-Marin and Louis, 2014, Grewal et al., 2014, Ha et al., 2014, Kuzhandaivel et al., 2014, Liu et al., 2014, Menuz et al., 2014, Mukunda et al., 2014, Ronderos et al., 2014, Schneider and Levine, 2014, Turner et al., 2014, Ueira-Vieira et al., 2014, Carlsson et al., 2013, Fujita et al., 2013, Garbaczewska et al., 2013, Getahun et al., 2013, Joo et al., 2013, Leal, 2013, Risse et al., 2013, Röllecke et al., 2013, Tan et al., 2013, Wang et al., 2013, Wasserman et al., 2013, Billeter et al., 2012, Nakagawa et al., 2012, Prieto-Godino et al., 2012, Schneider et al., 2012, Schneider et al., 2012, Smith, 2012, Trott et al., 2012, Gomez-Marin et al., 2011, Hoare et al., 2011, Montague et al., 2011, Nichols et al., 2011, Niewalda et al., 2011, Silbering et al., 2011, Vosshall and Hansson, 2011, Vosshall and Hansson, 2011.1.24, Wang et al., 2011, Wisotsky et al., 2011)
          or83b
          (Suyama et al., 2023, Cho et al., 2021, Riveron et al., 2013, Wang et al., 2013, Reis et al., 2010, Liu et al., 2007)
          orco
          (Ueda et al., 2023, Coya et al., 2022, He et al., 2022, Golovin et al., 2021, Jezovit et al., 2021, Poudel et al., 2021, Üçpunar and Grunwald Kadow, 2021, Yan et al., 2020, Zhang et al., 2020, Krämer et al., 2019, Lin et al., 2018, Yanagawa et al., 2018, Dombrovski et al., 2017, Ganguly et al., 2017, Hattori et al., 2017, Yamamoto and Kohatsu, 2017, Choi et al., 2016, Silbering et al., 2016, DeGennaro, 2015, Lin et al., 2015, Martin et al., 2013, Riveron et al., 2013)
          vainsA
          (Jin et al., 2008)
          Name Synonyms
          Odorant receptor 83b
          Odorant receptor co-receptor
          (Risse et al., 2013)
          Olfactory coreceptor
          (Kong et al., 2010)
          Or83b
          (Kong et al., 2010)
          Orco
          (Lone et al., 2016)
          odorant receptor 83b
          (Gross, 2006)
          odorant receptor co-receptor
          (Jung et al., 2018)
          odorant receptor coreceptor
          (Wang et al., 2013)
          olfactory co-receptor
          (Kong et al., 2010)
          olfactory receptor co-receptor
          (Vosshall and Hansson, 2011)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 31 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (416)