FB2024_03 , released June 25, 2024
Gene Group: GENERAL TRANSCRIPTION FACTORS
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General Information
Name
GENERAL TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
GTF
FlyBase ID
FBgg0000335
Date last reviewed
2015-09-29
Number of members
36
Description
Description
The general transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH) cooperate with RNA polymerase II to bind and open promoter DNA, to initiate RNA synthesis and stimulate the escape of RNA Pol II from the promoter. For initiation, RNA polymerase II assembles with the GTFs at promoter DNA to form the pre-initiation complex. (Adapted from PMID:25693126).
Notes on Group
Source Material
The GENERAL TRANSCRIPTION FACTORS Gene Group has been compiled using the following publication(s): Fan et al., 2017, Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Tora, 2002, Larochelle et al., 2001, Aoyagi and Wassarman, 2000, Wang et al., 1997, Austin and Biggin, 1996, Gong et al., 1995, Hansen and Tjian, 1995, Chen et al., 1994, Yokomori et al., 1994, and Wampler and Kadonaga, 1992 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
transcription initiation at RNA polymerase II promoter
Cellular Component
RNA polymerase II transcription regulator complex
Related Gene Groups
Component group(s)
TRANSCRIPTION FACTOR II A
TRANSCRIPTION FACTOR II B
TRANSCRIPTION FACTOR II D
TRANSCRIPTION FACTOR II E
TRANSCRIPTION FACTOR II F
TRANSCRIPTION FACTOR II H HOLOENZYME
Protein Complex group(s)
RNA POLYMERASE II
Members (36)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
CDK-ACTIVATING KINASE COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Cdk7
Cyclin-dependent kinase 7
DmCdk7, Mo15, DmMO15
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Larochelle et al., 2001, Aoyagi and Wassarman, 2000)
CycH
Cyclin H
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Larochelle et al., 2001, Aoyagi and Wassarman, 2000)
Mat1
Menage a trois 1
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Larochelle et al., 2001, Aoyagi and Wassarman, 2000)
GENERAL TRANSCRIPTION FACTOR II A COMPLEX - GERMLINE SPECIFIC VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
TfIIA-L
Transcription factor IIA L
TFIIA, dTFIIA
(Aoyagi and Wassarman, 2000)
TfIIA-S-2
TfIIA-S-2
TFIIA, EG:BACR7A4.7
(Aoyagi and Wassarman, 2000)
GENERAL TRANSCRIPTION FACTOR II A COMPLEX - TFIIA-S VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
TfIIA-L
Transcription factor IIA L
TFIIA, dTFIIA
(Aoyagi and Wassarman, 2000, Hansen and Tjian, 1995, Yokomori et al., 1994)
TfIIA-S
Transcription-factor-IIA-S
TFIIA, dTFIIA-S, F121
(Aoyagi and Wassarman, 2000, Hansen and Tjian, 1995, Yokomori et al., 1994)
TRANSCRIPTION FACTOR II B
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
TfIIB
Transcription factor IIB
dTFIIB, dmTFIIB
(Aoyagi and Wassarman, 2000, Hansen and Tjian, 1995, Wampler and Kadonaga, 1992)
TRANSCRIPTION FACTOR II D
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
caz
cabeza
dFUS, Sarcoma-associated RNA-binding fly homolog, SARFH, P19
(Aoyagi and Wassarman, 2000)
Gas41
Gas41
dGas41
(Aoyagi and Wassarman, 2000)
Taf1
TBP-associated factor 1
dTAFII230, dTAFII250, TAFII250, Taf250, TAFII230
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf2
TBP-associated factor 2
dTAFII150, TAFII150, Taf150, TFIID, TAFII150
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf3
TBP-associated factor 3
bip2, TFIID, Bric-a-brac interacting protein 2, TAFII155, dTAFII155
(Fan et al., 2017, Tora, 2002)
Taf4
TBP-associated factor 4
dTAFII110, TAFII110, TAF110, TAFII110, TFIID
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf5
TBP-associated factor 5
dTAFII80, Taf80, TAFII80, TFIID, TAFII80
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf6
TBP-associated factor 6
dTAFII60, TAFII60, Taf60, dTAFII62, TFIID
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf7
TBP-associated factor 7
TFIID, Taf55
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000)
Taf8
TBP-associated factor 8
prodos, pds, TFIID, HL-VIII, dmTAF8
(Fan et al., 2017, Tora, 2002)
Taf9
TBP-associated factor 9
dTAFII40, e(y)1, dTAFII42, TAFII40, TFIID
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf10
TBP-associated factor 10
TFIID, dTAFII24, TAFII24, dmTAF10
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000)
Taf10b
TBP-associated factor 10b
TFIID, dTAFII16, TAFII16
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000)
Taf11
TBP-associated factor 11
Taf30β, dTAFII30β, TAFII30β, TFIID, dTAFII30
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf12
TBP-associated factor 12
TBP-associated factor 30kD subunit α, Taf30α, dTAFII30α, TFIID, TAFII30α
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000, Chen et al., 1994)
Taf13
TBP-associated factor 13
TFIID, 38B.15, dTAFII18
(Fan et al., 2017, Tora, 2002, Aoyagi and Wassarman, 2000)
Tbp
TATA binding protein
TFIID, dTBP, TFIIDτ, TATA box-binding protein, dTFIID
(Fan et al., 2017, Aoyagi and Wassarman, 2000, Chen et al., 1994)
TRANSCRIPTION FACTOR II E
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
TfIIEα
Transcription factor IIEα
TFIIE
(Aoyagi and Wassarman, 2000, Wang et al., 1997, Austin and Biggin, 1996)
TfIIEβ
Transcription factor IIEβ
TFIIE, TFIIbeta
(Aoyagi and Wassarman, 2000, Wang et al., 1997, Austin and Biggin, 1996)
TRANSCRIPTION FACTOR II F
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ear
ENL/AF9-related
ENL/AF9, ENL/AF-9
(Aoyagi and Wassarman, 2000)
TfIIFα
Transcription factor IIFα
TFIIF
(Aoyagi and Wassarman, 2000, Austin and Biggin, 1996, Gong et al., 1995)
TfIIFβ
Transcription factor TFIIFβ
TFIIF, RAP30, dTFIIF30, l(3)j3C1
(Aoyagi and Wassarman, 2000, Austin and Biggin, 1996, Gong et al., 1995)
TRANSCRIPTION FACTOR II H - CORE COMPLEX
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
hay
haywire
XPB, ERCC3, TFIIH, DmXPB, nc2
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
mrn
marionette
p52, Tfb2, Dmp52, marionnette, nc16
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
Ssl1
Suppressor of stem-loop mutation
p44
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
Tfb1
Transcription factor B1
l(2)06949, p62, TfBl
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
Tfb4
Transcription factor B4
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
Tfb5
Transcription factor B5
p8, TTDA, lincRNA.843, Dmp8
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004)
Xpd
Xeroderma pigmentosum D
DmXPD, ERCC2, l(2)SH2137
(Stettler et al., 2015, Aguilar-Fuentes et al., 2008, Gutierrez et al., 2004, Aoyagi and Wassarman, 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
GTF
GENERAL TRANSCRIPTION FACTORS
Basal transcription factors
Secondary FlyBase ID(s)
References (15)