FB2024_03 , released June 25, 2024
Allele: Dmel\dallyΔGAG
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General Information
Symbol
Dmel\dallyΔGAG
Species
D. melanogaster
Name
FlyBase ID
FBal0399138
Feature type
allele
Associated gene
Dmel\dally
Associated Insertion(s)
TI{TI}dallyΔGAG
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Nakato et al., 2024)
Mutagen
CRISPR/Cas9
(Nakato et al., 2024)
Progenitor genotype
Associated Insertion(s)
TI{TI}dallyΔGAG
Cytology
Description

Five glycosaminoglycan (GAG)-attachment serine residues (at positions 549, 569, 573, 597, and 601) have been substituted for alanines in endogenous dally.

(Nakato et al., 2024)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3L:8,889,226..8,889,227 [+]
Nucleotide change:

AG8889226GC

Amino acid change:

S597A | dally-PA; S597A | dally-PB

Reported amino acid change:

S597A

Comment:

Fourth of five glycosaminoglycan (GAG)-attachment serine residues in dally that have been replaced with Ala. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nakato et al., 2024)
MNV
3L:8,889,238..8,889,239 [+]
Nucleotide change:

AG8889238GC

Amino acid change:

S601A | dally-PA; S601A | dally-PB

Reported amino acid change:

S601A

Comment:

Fifth of five glycosaminoglycan (GAG)-attachment serine residues in dally that have been replaced with Ala. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nakato et al., 2024)
point_mutation
3L:8,888,981..8,888,981 [+]
Nucleotide change:

T8888981G

Amino acid change:

S549A | dally-PA; S549A | dally-PB

Reported amino acid change:

S549A

Comment:

First of five glycosaminoglycan (GAG)-attachment serine residues in dally that have been replaced with Ala. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nakato et al., 2024)
point_mutation
3L:8,889,041..8,889,041 [+]
Nucleotide change:

T8889041G

Amino acid change:

S569A | dally-PA; S569A | dally-PB

Reported amino acid change:

S569A

Comment:

Second of five glycosaminoglycan (GAG)-attachment serine residues in dally that have been replaced with Ala. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nakato et al., 2024)
point_mutation
3L:8,889,053..8,889,053 [+]
Nucleotide change:

T8889053G

Amino acid change:

S573A | dally-PA; S573A | dally-PB

Reported amino acid change:

S573A

Comment:

Third of five glycosaminoglycan (GAG)-attachment serine residues in dally that have been replaced with Ala. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nakato et al., 2024)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      dallyΔGAG has visible | adult stage phenotype, suppressible by dlpΔGAG

      (Nakato et al., 2024)
      Other
      Statement
      Reference

      dallyΔGAG, dlpΔGAG has partially lethal phenotype

      (Nakato et al., 2024)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      dallyΔGAG has wing vein | ectopic phenotype, enhanceable by Df(3)DadP1883Δ32

      (Nakato et al., 2024)
      Suppressed by
      Statement
      Reference

      dallyΔGAG has wing vein | ectopic phenotype, suppressible by dlpΔGAG

      (Nakato et al., 2024)
      NOT Enhancer of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      dallyΔGAG is rescued by dallyhs.PJ

      (Nakato et al., 2024)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dallyΔGAG
      (Nakato et al., 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)