FB2024_03 , released June 25, 2024
Allele: Dmel\αCOP2750
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General Information
Symbol
Dmel\αCOP2750
Species
D. melanogaster
Name
FlyBase ID
FBal0392961
Feature type
allele
Associated gene
Dmel\αCOP
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Maddison et al., 2023)
Mutagen
ethyl methanesulfonate
(Maddison et al., 2023)
Progenitor genotype
Cytology
Description

28bp deletion within the αCOP coding sequence; results in a premature stop codon.

(Maddison et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,644,432..1,644,459 [-]
Comment:

A 28bp deletion within alphaCOP results in a frameshift and early translation termination. The deleted sequence is CTGCGTAAGAAGAACGTGGCTCCCGGGC.

(Maddison et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Phenotype Manifest In
      NOT Enhanced by
      Suppressed by
      Statement
      Reference

      αCOP2750 has axon | somatic clone | adult stage phenotype, suppressible by Disc\RFPmRFP.UAS.cGa.Tag:Mito(mAkap1),Tag:ER(yUBC6)/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has combined L1-L3 nerve | somatic clone | adult stage phenotype, suppressible by Disc\RFPmRFP.UAS.cGa.Tag:Mito(mAkap1),Tag:ER(yUBC6)/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has mitochondrion | somatic clone | adult stage | decreased number phenotype, suppressible by Disc\RFPmRFP.UAS.cGa.Tag:Mito(mAkap1),Tag:ER(yUBC6)/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has endoplasmic reticulum | somatic clone | adult stage | decreased number phenotype, suppressible | partially by Disc\RFPmRFP.UAS.cGa.Tag:Mito(mAkap1),Tag:ER(yUBC6)/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has axon | somatic clone | adult stage phenotype, suppressible | partially by Drp1HMC03230/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has mitochondrion | somatic clone | adult stage phenotype, suppressible | partially by Drp1HMC03230/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has combined L1-L3 nerve | somatic clone | adult stage phenotype, suppressible | partially by Drp1HMC03230/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has axon | somatic clone | adult stage phenotype, suppressible | partially by MarfUAS.cSa.Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has mitochondrion | somatic clone | adult stage | decreased number phenotype, suppressible | partially by MarfUAS.cSa.Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has combined L1-L3 nerve | somatic clone | adult stage phenotype, suppressible | partially by MarfUAS.cSa.Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has axon | somatic clone | adult stage phenotype, suppressible by Vap33UAS.Tag:FLAG,Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has mitochondrion | somatic clone | adult stage | decreased number phenotype, suppressible by Vap33UAS.Tag:FLAG,Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has combined L1-L3 nerve | somatic clone | adult stage phenotype, suppressible by Vap33UAS.Tag:FLAG,Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)

      αCOP2750 has endoplasmic reticulum | somatic clone | adult stage | decreased number phenotype, suppressible | partially by Scer\GAL4unspecified/MiroUAS.cGa

      (Maddison et al., 2023)

      αCOP2750 has endoplasmic reticulum | somatic clone | adult stage | decreased number phenotype, suppressible | partially by Vap33UAS.Tag:FLAG,Tag:HA/Scer\GAL4unspecified

      (Maddison et al., 2023)
      NOT suppressed by
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(3)2750
      (Maddison et al., 2023)
      αCOP2750
      Name Synonyms
      Secondary FlyBase IDs
        References (1)