FlyBase Allele Report: Dmel\Cep97[Δ]

General Information

Symbol

Dmel\Cep97^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0362411

Feature type

allele

Associated gene

Dmel\Cep97

Associated Insertion(s)

TI{TI}Cep97^Δ

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Dobbelaere et al., 2020)

Mutagen

ends-out gene targeting

(Dobbelaere et al., 2020)

Progenitor genotype

Associated Insertion(s)

TI{TI}Cep97^Δ

Cytology

Description

The entire coding sequence of Cep97 has been deleted and replaced with a w^+* marker.

(Dobbelaere et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:3,867,982..3,871,189 [+]

Comment:

The coding sequence of Cep97 has been deleted and replaced with a w^+* marker.

(Dobbelaere and Dammermann, 2020.10.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior

(Dobbelaere et al., 2020)

abnormal touch response | third instar larval stage

(Dobbelaere et al., 2020)

decreased fecundity | male

(Dobbelaere et al., 2020)

male semi-fertile

(Ryniawec et al., 2023)

male semi-sterile

(Dobbelaere et al., 2020)

viable

(Dobbelaere et al., 2020)

visible

(Dobbelaere et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cep97^Δ adults exhibit a reduction in their climbing ability and abnormal wing posture.

In Cep97^Δ pupal leg chordotonal organs, cilia are frequently missing and basal bodies appear abnormal.

Cep97^Δ males exhibit a reduction in sperm motility and abnormal pupal spermatids in which axonemes are incomplete or missing.

In Cep97^Δ animals the primary spermatocyte centrioles are longer while the wing disc centrioles are shorter with prominent extensions of individual microtubules emanating from one end.

(Dobbelaere et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Cep97^Δ has male semi-sterile phenotype, enhanceable by Atat^KG05974

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, enhanceable by Atat^KG05974

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, enhanceable by Atat^KG05974

(Dobbelaere et al., 2020)

NOT Enhanced by

Statement

Reference

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-enhanceable by Atat^KG05974

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

NOT suppressed by

Statement

Reference

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-suppressible by Atat^KG05974

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal locomotor behavior phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has decreased fecundity | male phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has male semi-sterile phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has abnormal touch response | third instar larval stage phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Enhancer of

Statement

Reference

Cep97^Δ is an enhancer of abnormal locomotor behavior phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is an enhancer of abnormal touch response | third instar larval stage phenotype of Atat^KG05974

(Dobbelaere et al., 2020)

NOT Enhancer of

Statement

Reference

Cep97^Δ is a non-enhancer of male semi-sterile phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of decreased fecundity | male phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of male semi-sterile phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of abnormal touch response | third instar larval stage phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of abnormal locomotor behavior phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of decreased fecundity | male phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of abnormal touch response | third instar larval stage phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

NOT Suppressor of

Statement

Reference

Cep97^Δ is a non-suppressor of abnormal touch response | third instar larval stage phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of male semi-sterile phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of male semi-sterile phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of abnormal touch response | third instar larval stage phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of abnormal locomotor behavior phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of decreased fecundity | male phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of decreased fecundity | male phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Other

Statement

Reference

Cep104^Δ, Cep97^Δ has decreased rate of adult locomotory behavior phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has male semi-sterile phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has decreased size | spermatogenesis phenotype

(Ryniawec et al., 2023)

Cep97^Δ, HDAC6^KO has viable phenotype

(Dobbelaere et al., 2020)

Cep97^Δ, Sirt2^5B-2-35 has viable phenotype

(Dobbelaere et al., 2020)

Atat^MI10200, Cep97^Δ has visible phenotype

(Dobbelaere et al., 2020)

Atat^MI10200, Cep97^Δ has lethal - all die before end of larval stage phenotype

(Dobbelaere et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Cep97^Δ has spermatid axoneme | P-stage phenotype, enhanceable by Atat^KG05974

(Dobbelaere et al., 2020)

NOT Enhanced by

Statement

Reference

Cep97^Δ has centriole | spermatogenesis phenotype, non-enhanceable by Cep104^Δ

(Ryniawec et al., 2023)

Cep97^Δ has primary spermatocyte | P-stage phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has centriole phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-enhanceable by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has spermatid axoneme | P-stage phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-enhanceable by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has spermatid axoneme | P-stage phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-enhanceable by HDAC6^KO

(Dobbelaere et al., 2020)

Suppressed by

Statement

Reference

Cep97^Δ has wing disc | third instar larval stage phenotype, suppressible | partially by Atat^KG05974

(Dobbelaere et al., 2020)

Cep97^Δ has primary spermatocyte | P-stage phenotype, suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has primary spermatocyte | P-stage phenotype, suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has primary spermatocyte | P-stage phenotype, suppressible by Atat^KG05974

(Dobbelaere et al., 2020)

NOT suppressed by

Statement

Reference

Cep97^Δ has centriole | spermatogenesis phenotype, non-suppressible by Cep104^Δ

(Ryniawec et al., 2023)

Cep97^Δ has primary spermatocyte | P-stage phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has centriole phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has spermatid axoneme | P-stage phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has spermatid axoneme | P-stage phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-suppressible by HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ has wing disc | third instar larval stage phenotype, non-suppressible by Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ has spermatozoon phenotype, non-suppressible by Cp110^Δ

(Dobbelaere et al., 2020)

Enhancer of

Statement

Reference

Cep97^Δ is an enhancer of centriole | spermatogenesis phenotype of Cep104^Δ

(Ryniawec et al., 2023)

Cep97^Δ is an enhancer of spermatozoon phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

NOT Enhancer of

Statement

Reference

Cep97^Δ is a non-enhancer of spermatozoon phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of spermatid axoneme | P-stage phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of centriole phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of wing disc | third instar larval stage phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of spermatozoon phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-enhancer of spermatid axoneme | P-stage phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

NOT Suppressor of

Statement

Reference

Cep97^Δ is a non-suppressor of spermatozoon phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of spermatid axoneme | P-stage phenotype of HDAC6^KO

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of spermatozoon phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of spermatid axoneme | P-stage phenotype of Sirt2^5B-2-35

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of centriole phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Cep97^Δ is a non-suppressor of wing disc | third instar larval stage phenotype of Cp110^Δ

(Dobbelaere et al., 2020)

Other

Statement

Reference

Cep104^Δ, Cep97^Δ has cystic bulge | decreased number phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has waste bag | decreased number phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has seminal vesicle phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has spermatid phenotype

(Ryniawec et al., 2023)

Cep104^Δ, Cep97^Δ has spermatid axoneme phenotype

(Ryniawec et al., 2023)

Atat^MI10200, Cep97^Δ has wing phenotype

(Dobbelaere et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

In wing discs, Atat^KG05974 suppresses the prominent extensions of individual microtubules emanating from one end of centrioles phenotype while it does not modify the centriole length phenotype of Cep97^Δ.

(Dobbelaere et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cep97^Δ is rescued by Cep97^GFP

(Dobbelaere et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cep97^Δ

(Dobbelaere et al., 2020)

Cep97Δ

(Aydogan et al., 2022)

cep97^Δ

(Ryniawec et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (4)

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