FB2024_03 , released June 25, 2024
Allele: Hsap\TARDBPUAS.TDPBR
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General Information
Symbol
Hsap\TARDBPUAS.TDPBR
Species
H. sapiens
Name
FlyBase ID
FBal0344470
Feature type
allele
Associated gene
Hsap\TARDBP
Associated Insertion(s)
Carried in Construct
M{UAS-hTARDBP.TDPBR}
Also Known As
UAS-TDP-43_TDPBR
Key Links
Transgenic product class
wild_type
(Pons et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pons et al., 2017)
Mutagen
in vitro construct
(Pons et al., 2017)
Progenitor genotype
Carried in construct
M{UAS-hTARDBP.TDPBR}
Cytology
Description

UASt regulatory sequences drive expression of the wild-type Hsap\TARDBP coding sequence. The TDPBR (TDP-43 binding region) regulatory sequence from the Hsap\TARDBP 3' UTR has been inserted downstream of the coding sequence.

(Pons et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\TARDBP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  amyotrophic lateral sclerosis type 10
      is ameliorated by CG42724HMC04044
      (Pons et al., 2018)
      is ameliorated by CG42724HMS00621
      (Pons et al., 2018)
      is exacerbated by CG42724UY5237
      (Pons et al., 2018)
      is exacerbated by Hsap\SRSF1UAS.cAa
      (Pons et al., 2017)
      is exacerbated by Rbp1GD9289
      (Pons et al., 2017)
      is ameliorated by SF2GD12097
      (Pons et al., 2017)
      is exacerbated by SF2UAS.GFP
      (Pons et al., 2017)
      is exacerbated by Sf3b1GD8837
      (Pons et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU does not cause a discernible eye phenotypes.

      (Miguel et al., 2018)

      The expression of Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU results in no eye phenotype.

      The expression of Hsap\TARDBPUAS.TDPBR / Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU / Scer\GAL4GMR.PU results in no eye phenotype.

      (Pons et al., 2018)

      Flies expressing Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU have structurally normal eyes.

      (Pons et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Coexpression of CG42724UY5237 and Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU results in no eye phenotype with only one copy for each transgene and driver.

      Coexpression of Hsap\TARDBPUAS.TDPBR / Hsap\TARDBPUAS.TDPBR enhances the rough eye phenotype induced by expression of CG42724UY5237 under the control of Scer\GAL4GMR.PU / Scer\GAL4GMR.PU.

      (Pons et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\TARDBPUAS.TDPBR
      Name Synonyms
      Secondary FlyBase IDs
        References (4)