FlyBase Allele Report: Dmel\Smg5[C391]

General Information

Symbol

Dmel\Smg5^C391

Species

D. melanogaster

Name

FlyBase ID

FBal0342123

Feature type

allele

Associated gene

Dmel\Smg5

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Nelson et al., 2018)

Mutagen

ethyl methanesulfonate

(Nelson et al., 2018)

Progenitor genotype

Cytology

Description

Mutation in splice acceptor site.

(Nelson et al., 2018)

Nucleotide substitution: G2227A.

(Nelson et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:13,901,982..13,901,982 [-]

Nucleotide change:

G13901982A

Reported nucleotide change:

G2227A

Comment:

Nucleotide substitution: AG changed to AA in the splice acceptor.

(Nelson et al., 2018)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage (with Smg5^G115)

(Nelson et al., 2018)

lethal (with Df(2L)b80c1)

(Nelson et al., 2018)

lethal (with Df(2L)b82a2)

(Nelson et al., 2018)

lethal (with Df(2L)BSC345)

(Nelson et al., 2018)

lethal (with Smg5^34Eb-2)

(Cook, 2022.7.7)

lethal (with Smg5^G115)

(Nelson et al., 2018)

lethal - all die before end of P-stage (with Smg5^G115)

(Nelson et al., 2018)

majority die during pupal stage (with Smg5^G115)

(Nelson et al., 2018)

Phenotype Manifest In

Detailed Description

Statement

Reference

Smg5^C391/Smg5^G115 mutants have developmental delays, spending almost twice as long in larval stages as control animals.

(Nelson et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Smg5^G115/Smg5^C391 has majority die during pupal stage phenotype, non-enhanceable by nonC^32AP/nonC^32AP

(Nelson et al., 2018)

Smg5^G115/Smg5^C391 has lethal phenotype, non-enhanceable by nonC^32AP/nonC^32AP

(Nelson et al., 2018)

Suppressed by

Statement

Reference

Smg5^G115/Smg5^C391 has lethal phenotype, suppressible by Gadd45^F17/Gadd45^F17

(Nelson et al., 2018)

NOT suppressed by

Statement

Reference

Smg5^G115/Smg5^C391 has abnormal developmental rate | larval stage phenotype, non-suppressible by nonC^32AP/nonC^32AP

(Nelson et al., 2018)

Smg5^G115/Smg5^C391 has majority die during pupal stage phenotype, non-suppressible by nonC^32AP/nonC^32AP

(Nelson et al., 2018)

Smg5^G115/Smg5^C391 has lethal phenotype, non-suppressible by nonC^32AP/nonC^32AP

(Nelson et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Smg5^C391/Df(2L)b80c1 is rescued by Smg5^+tGR

(Nelson et al., 2018)

Partially rescued by

Smg5^G115/Smg5^C391 is partially rescued by Smg5^+tGR

(Nelson et al., 2018)

Smg5^C391/Df(2L)b82a2 is partially rescued by Smg5^+tGR

(Nelson et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

81033

w^*; Smg5^C391 P{neoFRT}40A/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Smg5^C391

(Cook, 2022.7.7, Nelson et al., 2018, Nelson et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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