FB2024_03 , released June 25, 2024
Allele: Dmel\LarMI03443-TG4.1
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General Information
Symbol
Dmel\LarMI03443-TG4.1
Species
D. melanogaster
Name
FlyBase ID
FBal0336323
Feature type
allele
Associated gene
Dmel\Lar
Associated Insertion(s)
Mi{Trojan-GAL4.1}LarMI03443-TG4.1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Poe et al., 2017)
Progenitor genotype
Mi{MIC}LarMI03443
(Poe et al., 2017)
Associated Insertion(s)
Mi{Trojan-GAL4.1}LarMI03443-TG4.1
Cytology
Description

The RMCE cassette of the Mi{MIC}LarMI03443 insertion has been replaced with a Trojan-Gal4 cassette.

(Poe et al., 2017)
Allele components
Component
Use(s)
Inserted element
Mi{Trojan-GAL4.1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      LarMI03443-TG4.1 heterozygous third instar larvae do not display any defects in the dendritic arbor of class IV dendritic arborizing neurons but LarCRISPR.3/LarMI03443-TG4.1 transheterozygotes show very mild decrease in total dendrite density (but not in terminal dendrite density or numbers).

      (Poe et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Third instar larvae heterozygous for LarMI03443-TG4.1 and also expressing Ptp69DJF03399 under the Scer\GAL4Lar-MI03443-TG4.1 driver (which is inherent to the LarMI03443-TG4.1 allele) display strong reduction in the total and terminal dendrite density as well as terminal dendrite numbers in class IV dendritic arborizing neurons relative to controls, this phenotype is not further worsened by combination with LarCRISPR.3.

      (Poe et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LarMI03443-TG4.1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)