FlyBase Allele Report: Dmel\Sarm[ΔARM.UAS.Tag:MYC]

General Information

Symbol

Dmel\Sarm^{ΔARM.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0327550

Feature type

allele

Associated gene

Dmel\Sarm

Associated Insertion(s)

Carried in Construct

P{UAS-Sarm.ΔARM.MYC}

Also Known As

dsarm^ΔARM

Key Links

Transgenic product class

inframe_deletion

(Neukomm et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Neukomm et al., 2017)

Mutagen

in vitro construct

(Neukomm et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-Sarm.ΔARM.MYC}

Cytology

Description

UAS regulatory sequences drive expression of Ect4 with deletion (aa697-812) of the ARM domain. Tagged with Tag:MYC.

(Neukomm et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sarm

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4^VGlut-OK371

(Neukomm et al., 2017)

abnormal neuroanatomy | larval stage | progressive, with Scer\GAL4^ppk.PH

(Ji et al., 2022)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Somatic neural clones expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^VGlut-OK371 undergo spontaneous cell body and axon degeneration. Similarly, expression of Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} (with the Scer\GAL4^ppk.PG driver) leads to neurodegeneration and loss of the multidendritic ddaC neurons in third instar larvae as well as Pdf-positive neurons (under the Scer\GAL4^P2.4.Pdf driver combined with tub-Gal80[ts] to restrict the time of expression until adulthood) in adult flies.

(Neukomm et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has abnormal neuroanatomy | first instar larval stage | progressive phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has abnormal neuroanatomy | second instar larval stage | progressive phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by Df(3L)BSC411

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

NOT suppressed by

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has abnormal neuroanatomy | third instar larval stage | progressive phenotype, non-suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by hiw^ΔN

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul1^k01207

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul3^gft2

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul3⁰⁶⁴³⁰

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul3^EY11031

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul4^11L

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Cul4^KG02900

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6211

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3R)3450

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC413

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3L)ED4486

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Uba1^s3484

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Uba1^LL03617

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(1)G1

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Roc1b^dc3

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC247

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Nedd8^KG03071

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by bsk²

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(2L)flp170B

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Mkk4^e01485

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6149

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by hep^r75

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has abnormal neuroanatomy | adult stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of abnormal wound healing | adult stage phenotype of Nmnat^Δ4790-1, axed⁰⁰¹¹

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of abnormal wound healing | adult stage phenotype of Nmnat^Δ4790-1, axed²⁰⁹⁴

(Neukomm et al., 2017)

Other

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Sarm⁸⁹⁶, Scer\GAL4^VGlut-OK371 has abnormal neuroanatomy | adult stage phenotype

(Neukomm et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has dendrite | second instar larval stage phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has larval dorsal multidendritic neuron ddaC | second instar larval stage phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has dendrite | first instar larval stage phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has larval dorsal multidendritic neuron ddaC | first instar larval stage phenotype, suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, suppressible by axed²⁰⁹⁴

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, suppressible by Df(3L)BSC411

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, suppressible by Df(3L)BSC411

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, suppressible by axed⁰⁰¹¹

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | third instar larval stage phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has axon | third instar larval stage phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has adult Pdf neuron phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has neurite | adult stage phenotype, suppressible | partially by Mmus\Wld^S.UAS, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

NOT suppressed by

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has dendrite | third instar larval stage phenotype, non-suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PH has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype, non-suppressible by drpr^indel/drpr^indel

(Ji et al., 2022)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by hiw^ΔN

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by hiw^ΔN

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul4^11L

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul4^11L

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul4^KG02900

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul4^KG02900

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6211

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6211

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3R)3450

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3R)3450

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC413

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC413

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul1^k01207

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3L)ED4486

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3L)ED4486

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Uba1^s3484

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Uba1^s3484

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Uba1^LL03617

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Uba1^LL03617

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(1)G1

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(1)G1

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Roc1b^dc3

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Roc1b^dc3

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul1^k01207

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC247

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3L)BSC247

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Nedd8^KG03071

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Nedd8^KG03071

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by bsk²

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has axon | somatic clone | adult stage phenotype, non-suppressible by bsk²

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(2L)flp170B

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has axon | somatic clone | adult stage phenotype, non-suppressible by Df(2L)flp170B

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Mkk4^e01485

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has axon | somatic clone | adult stage phenotype, non-suppressible by Mkk4^e01485

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul3^gft2

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6149

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has axon | somatic clone | adult stage phenotype, non-suppressible by Df(3R)Exel6149

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by hep^r75

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^nSyb.PS has axon | somatic clone | adult stage phenotype, non-suppressible by hep^r75

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^ppk.PG has axon | third instar larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ppk.PG

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has adult Pdf neuron phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^P2.4.Pdf has neurite | adult stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^P2.4.Pdf

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul3^gft2

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul3⁰⁶⁴³⁰

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul3⁰⁶⁴³⁰

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has sensory neuron | somatic clone | adult stage phenotype, non-suppressible by Cul3^EY11031

(Neukomm et al., 2017)

Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371 has axon | somatic clone | adult stage phenotype, non-suppressible by Cul3^EY11031

(Neukomm et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed⁰⁰¹¹

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of axon | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed⁰⁰¹¹

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of neuronal cell body | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed⁰⁰¹¹

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed²⁰⁹⁴

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of axon | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed²⁰⁹⁴

(Neukomm et al., 2017)

Scer\GAL4^VGlut-OK371/Sarm^{ΔARM.UAS.Tag:MYC} is a non-suppressor of neuronal cell body | somatic clone | adult stage phenotype of Nmnat^Δ4790-1, axed²⁰⁹⁴

(Neukomm et al., 2017)

Other

Statement

Reference

Sarm^{ΔARM.UAS.Tag:MYC}, Sarm⁸⁹⁶, Scer\GAL4^VGlut-OK371 has axon | adult stage phenotype

(Neukomm et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Ect4⁸⁹⁶ mutant MARCM clones in sensory neurons in the adult wing expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^VGlut-OK371 undergo spontaneous cell body and axon degeneration, as do clones expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} alone (using either the Scer\GAL4^VGlut-OK371 or the Scer\GAL4^nSyb.PS driver). The axon degeneration in these clones can be suppressed by combination with axed²⁰⁹⁴, axed⁰⁰¹¹ or Df(3L)BSC411 but not by combination with hiw^ΔN or any of the following: Cul1^k01207, Cul3^gft2, Cul3⁰⁶⁴³⁰, Cul3^EY11031, Cul4^11L, Cul4^KG02900, Df(3R)Exel6211, Df(3R)3450, Df(3L)BSC413, Df(3L)ED4486, Uba1^s3484, Uba1^LL03617, Df(1)G1, Roc1b^dc3, Df(3L)BSC247, Nedd8^KG03071, bsk², Df(2L)flp170B, Mkk4^e01485, Df(3R)Exel6149 or hep^r75.

The Nmnat^Δ4790-1,axed⁰⁰¹¹ as well as Nmnat^Δ4790-1,axed²⁰⁹⁴ double mutant clones display defective injury-induced axon degeneration (severed axons remain intact following an axotomy, instead of being cleared away) which cannot be overcome by expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the Scer\GAL4^VGlut-OK371 driver in the mutant clones.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

The loss of multidendritic ddaC neurons in third instar larvae induced by Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} expression (with the Scer\GAL4^ppk.PG driver) in third instar larvae as well as neurite degeneration in Pdf-positive neurons in adult flies (under the Scer\GAL4^P2.4.Pdf driver combined with tub-Gal80[ts] to restrict the expression to adulthood) cannot be rescued by co-expression of BacA\p35^Scer\UAS.cHa and can be only partially improved by co-expression of Mmus\Wld^S.Scer\UAS.

(Neukomm et al., 2017)

Complementation and Rescue Data

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Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC}

Ect4^{ΔARM.UAS.Tag:MYC}

Sarm^{ΔARM.UAS.Tag:MYC}

dsarm^ΔARM

(Neukomm et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (3)

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