Deletion that encompasses exon 1 through part of exon 2 of Marcal1 (deletion of 2L:4955554..4956729 release 6 genome).
1176 bp deletion which removes exon 1 and part of exon 2 of Marcal1.
Marcal1del/Marcal1kh1 transheterozygous mutants show defects in the DNA double-strand break repair as assessed by the P{hswa} and P{wIw.FRT} male germline assay: the mutants display significantly reduced synthesis-dependent strand annealing (SDSA) repair (both in percentage of total progeny scored and in number of males with observable SDSA events in the progeny) as well as reduced single-strand annealing (SSA) capacity relative to wild-type controls.
Marcal1del/Marcal1kh1 is a non-enhancer of abnormal DNA repair | adult stage phenotype of Brca247
Marcal1del/Marcal1kh1 is a non-suppressor of abnormal DNA repair | adult stage phenotype of Brca247
The defects in the DNA double-strand break repair (no synthesis-dependent strand annealing repair events and a compensatory increase in the percentage of end joining repair events) as assessed by the P{hswa} male germline assay characteristic for Brca247 are not modified by combination with Marcal1del/Marcal1kh1 alleles.