FB2024_03 , released June 25, 2024
Allele: Dmel\Lsm12aΔ6
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General Information
Symbol
Dmel\Lsm12aΔ6
Species
D. melanogaster
Name
FlyBase ID
FBal0326141
Feature type
allele
Associated gene
Dmel\Lsm12a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Lee et al., 2017)
Mutagen
P-element activity
(Lee et al., 2017)
Progenitor genotype
P{EPgy2}Lsm12aEY01098
(Lee et al., 2017)
Caused by aberration
Df(1)Lsm12aΔ6
Cytology
Description

Imprecise excision of P{EPgy2}Lsm12EY01098 results in deletion of parts of Lsm12 and Chrac-16.

(Lee et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lsm12Δ6 hemizygous as well as Lsm12Δ6/Df(1)ED7153 transheterozygous adults display aberrant long-period circadian locomotor rhythm under free-running constant dark conditions. Lsm12Δ6 mutants show normal morphology of Pdf-positive pacemaker neurons in the adult brain but the oscillation pattern of the circadian proteins per and tim in various clusters of pacemaker neurons is disrupted.

      (Lee et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The aberrant long-period circadian locomotor rhythm under free-running constant dark conditions characteristic for Lsm12Δ6 mutant adults is partially rescued by combination with a single copy of perT:Ivir\HA1,T:Zzzz\His6 or by Scer\GAL4cry.PE-driven expression of perScer\UAS.cBa (but not Atx2Scer\UAS.T:Zzzz\FLAG or tyfScer\UAS.T:Zzzz\FLAG).

      (Lee et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Lsm12aΔ6 is rescued by Scer\GAL4elav.Switch.PO/Lsm12aUAS.Tag:FLAG

      (Lee et al., 2017)
      Comments

      The long-period circadian locomotor rhythm under free-running constant dark conditions observed in Lsm12Δ6 mutant adults is rescued by expression of Lsm12Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4cry.PE or the inducible Scer\GAL4elav.Switch.PO driver (using RU486 food supplementation to limit the expression to adulthood).

      (Lee et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lsm12Δ6
      (Lee et al., 2017)
      Lsm12aΔ6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)