FlyBase Allele Report: Hsap\TPT1[UAS.cHa]

General Information

Symbol

Hsap\TPT1^UAS.cHa

Species

H. sapiens

Name

FlyBase ID

FBal0318882

Feature type

allele

Associated gene

Hsap\TPT1

Associated Insertion(s)

Carried in Construct

P{UAS-hTCTP.H}

Also Known As

UAS-hTCTP

Key Links

Transgenic product class

cDNA

(Hsu et al., 2007)

wild_type

(Hsu et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hsu et al., 2007)

wild_type

(Hsu et al., 2007)

Mutagen

in vitro construct

(Hsu et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-hTCTP.H}

Cytology

Description

UAS regulatory sequences drive expression of a full-length Hsap\TPT1 cDNA.

(Hsu et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\TPT1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/Hsap\TPT1^UAS.cHa is a suppressor | partially of lethal phenotype of Tctp^h59

(Hsu et al., 2007)

Scer\GAL4^ey.PH/Hsap\TPT1^UAS.cHa is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, Tctp^RNAi.UAS

(Hsu et al., 2007)

Hsap\TPT1^UAS.cHa, Scer\GAL4^ey.PH is a suppressor of visible phenotype of Scer\GAL4^ey.PH, Tctp^RNAi.UAS

(Hsu et al., 2007)

NOT Suppressor of

Statement

Reference

Hsap\TPT1^UAS.cHa, Scer\GAL4^AB1 is a non-suppressor of decreased cell size | third instar larval stage phenotype of Scer\GAL4^AB1, foxo^{UAS.ORF.GW.Tag:HA}

(Nam et al., 2022)

Hsap\TPT1^UAS.cHa, Scer\GAL4^AB1 is a non-suppressor of decreased size | third instar larval stage phenotype of Scer\GAL4^AB1, foxo^{UAS.ORF.GW.Tag:HA}

(Nam et al., 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^ey.PH/Hsap\TPT1^UAS.cHa is a suppressor of 1st posterior cell phenotype of Scer\GAL4^ptc-559.1, Tctp^RNAi.UAS

(Hsu et al., 2007)

Hsap\TPT1^UAS.cHa, Scer\GAL4^ey.PH is a suppressor of eye phenotype of Scer\GAL4^ey.PH, Tctp^RNAi.UAS

(Hsu et al., 2007)

NOT Suppressor of

Statement

Reference

Hsap\TPT1^UAS.cHa, Scer\GAL4^AB1 is a non-suppressor of embryonic/larval salivary gland | third instar larval stage phenotype of Scer\GAL4^AB1, foxo^{UAS.ORF.GW.Tag:HA}

(Nam et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\TPT1^Scer\UAS.cHa under the control of Scer\GAL4^Act.PU rescues Tctp^h59 homozygotes to the pupal or adult stage.

Co-expression of Hsap\TPT1^Scer\UAS.cHa suppresses the reduction in eye size seen in animals expressing Tctp^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ey.PH.

Co-expression of Hsap\TPT1^Scer\UAS.cHa suppresses the phenotype of a reduced distance between wing veins L3 and L4 which is seen in animals expressing Tctp^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ptc-559.1.

(Hsu et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\TPT1^Scer\UAS.cHa

Hsap\TPT1^UAS.cHa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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