FB2024_03 , released June 25, 2024
Allele: Dmel\rheaC110
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General Information
Symbol
Dmel\rheaC110
Species
D. melanogaster
Name
FlyBase ID
FBal0304190
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Also Known As
talin2509
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Brown, 2023.8.21, Klapholz et al., 2015)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Klapholz et al., 2015)

Amino acid replacement: R2510term.

(Klapholz et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,572,528..8,572,528 [+]
Nucleotide change:

C8572528T

Reported nucleotide change:

C?T

Amino acid change:

R2510term | rhea-PB; R2510term | rhea-PE; R2510term | rhea-PF; R2489term | rhea-PG; R2510term | rhea-PH

Reported amino acid change:

R2510term

(Klapholz et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing result in a moderate wing blister phenotype (blisters in more than 50% of wings).

      Homozygous embryos have a mild (hypomorphic) muscle detachment phenotype.

      More than 25% of homozygotes fail to undergo germband retraction (this phenotype is indistinguishable from that of a null mutation).

      (Klapholz et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rheaC110 homozygosity leads to a strong reduction in the number of ectopic VincCO.Scer\UAS.P\T.T:Equa\eqFP578-TagRFP-positive cytoplasmic protein aggregates formed in follicle cell clones and embryonic muscles, upon expression under the control of Scer\GAL4Act5C.PU and Scer\GAL4Mef2.PU, respectively.

      (Maartens et al., 2016)

      Df(1)Vinc2 rheaC110 double mutant embryos show complete muscle detachment, a stronger muscle detachment phenotype phenotype than seen in rheaA109 single mutant embryos (this is a non-specific additive effect).

      (Klapholz et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rheaC110
      (Brown, 2023.8.21)
      talin2509
      (Maartens et al., 2016, Klapholz et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)