FB2024_03 , released June 25, 2024
Allele: Dmel\MED191
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General Information
Symbol
Dmel\MED191
Species
D. melanogaster
Name
FlyBase ID
FBal0296245
Feature type
allele
Associated gene
Dmel\MED19
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Boube et al., 2014)
Mutagen
P-element activity
(Boube et al., 2014)
Progenitor genotype
P{EPgy2}EY16159
(Boube et al., 2014)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 14bp deletion 5' to the MED19 transcription start site.

(Boube et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:17,846,542..17,846,559 [-]
Comment:

Inferred location of 14 bp deletion resulting from the imprecise excision of P{EPgy2}EY16159, which removes 14 bp upstream of the insertion (relative to MED19 transcription.

(Boube et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MED191/MED192 pupae show a fully penetrant loss of anterior spiracles.

      (Boube et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      MED192/MED191 is rescued by Scer\GAL4arm.PU/MED19UAS.C-Venus

      (Boube et al., 2014)

      MED192/MED191 is rescued by MED19Ubi.PB

      (Boube et al., 2014)
      Not rescued by

      MED192/MED191 is not rescued by MED19ΔHIM.UAS.C-Venus/Scer\GAL4arm.PU

      (Boube et al., 2014)
      Comments

      Expression of MED19Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4arm.PU rescues the lethality of MED191/MED192 animals.

      Expression of MED19ΔHIM.Scer\UAS.T:Avic\GFP-VC under the control of Scer\GAL4arm.PU fails to rescue the lethality of MED191/MED192 animals.

      (Boube et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MED191
      Med191
      (Boube et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)