Nonsense mutation: W205Stop in the short isoform, W336Stop in the long isoform.
G10406975A
W336term | flw-PA; W205term | flw-PB; W205term | flw-PC; W205term | flw-PD
W336term
G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The amino acid change was reported as W205Stop in the short isoform and W336Stop in the long isoform.
Homozygous female germline clones result in small actin ring canals.
flwXE55D is rescued by Scer\GAL4Act5C.PI/flwUAS.cRa
flwXE55D is not rescued by Scer\GAL4Tub.PU/flwUAS.cRa
flwXE55D is not rescued by Scer\GAL4VP16.mat.αTub67C/flwUAS.cRa
Expression of flwScer\UAS.cRa under the control of Scer\GAL4Act5C.PI rescues the lethality of flwXE55D.
Expression of flwScer\UAS.cRa under the control of either Scer\GAL4tub.PU or Scer\GAL4mat.αTub67C.T:Hsim\VP16 does not rescue the lethality of flwXE55D.