FB2024_03 , released June 25, 2024
Allele: Dmel\hepCA.sev.Tag:MYC
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General Information
Symbol
Dmel\hepCA.sev.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0288398
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Two sev enhancer sequences upstream of a 'hsp70' promoter regulate expression of the hepCA cDNA containing the hep-RC cDNA with Ser-346, Thr-350 and Ser-352 changed to Asp residues, rendering the kinase constitutively active. There is a Tag:MYC tag at the N-terminus.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hepCA.sev.T:Hsap\MYC animals display a rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

hepCA.sev.Tag:MYC has eye phenotype, enhanceable by pucA251.1F3/puc[+]

NOT Enhanced by
Statement
Reference

hepCA.sev.Tag:MYC has eye phenotype, non-enhanceable by slpr921/slpr[+]

hepCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphS-331/alph[+]

hepCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphGMR

hepCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphS-331.GMR/alph[+]

Suppressed by
Statement
Reference

hepCA.sev.Tag:MYC has eye phenotype, suppressible by bsk1/bsk[+]

NOT suppressed by
Statement
Reference

hepCA.sev.Tag:MYC has eye phenotype, non-suppressible by slpr921/slpr[+]

hepCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphS-331/alph[+]

hepCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphGMR

hepCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphS-331.GMR/alph[+]

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
hepCA.sev.T:Hsap\MYC
hepCA.sev.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (1)