FB2024_03 , released June 25, 2024
Allele: Dmel\Atg1UAS.cTa
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General Information
Symbol
Dmel\Atg1UAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0287781
Feature type
allele
Associated gene
Dmel\Atg1
Associated Insertion(s)
Carried in Construct
P{UAS-unc-51.WT}
Also Known As
UAS-unc-51WT
Key Links
Transgenic product class
cDNA
(Wairkar et al., 2009)
wild_type
(Wairkar et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wairkar et al., 2009)
wild_type
(Wairkar et al., 2009)
Mutagen
in vitro construct
(Wairkar et al., 2009, Toda et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-unc-51.WT}
Cytology
Description

Expression of Atg1 cDNA (LD18893) is under the control of UAS sequences.

(Wairkar et al., 2009)

UAS regulatory sequences drive expression of wild-type Atg1.

(Toda et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Atg1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Evoked excitatory junction potentials at the neuromuscular junctions of Atg1Scer\UAS.cWa; Scer\GAL4elav.PLu larvae are significantly decreased compared to wild-type.

      (Wairkar et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Atg1UAS.cTa, Scer\GAL4bbg-C96 is an enhancer of visible phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Atg1UAS.cTa, Scer\GAL4bbg-C96 is an enhancer of wing margin phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing nicking phenotype caused by expression of domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also co-expressing Atg1Scer\UAS.cTa.

      (Kwon et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/Atg1UAS.cTa rescues Atg125/Atg13

      (Toda et al., 2008)
      Partially rescues

      Atg1UAS.cTa partially rescues Atg125

      (Mochizuki et al., 2011)

      Atg1UAS.cTa/Scer\GAL4elav.PLu partially rescues Atg13

      (Wairkar et al., 2009)
      Fails to rescue

      Atg1UAS.cTa/Scer\GAL4G7 fails to rescue Atg13

      (Wairkar et al., 2009)
      Comments

      Atg1Scer\UAS.cWa; Scer\GAL4elav.PLu rescues the structural phenotypes seen in the neuromuscular junctions (NMJ) of Atg13 homozygous larvae: NMJ size, puncta density and apposition of pre and post-synaptic components are all restored. However, neurophysiological defects in these NMJs are not rescued. Neither neurophysiological nor structural defects in these NMJs are rescued when a post-synaptic driver, Scer\GAL4G7, is used in place of Atg1Scer\UAS.cWa.

      (Wairkar et al., 2009)

      The axonal transport defect seen in Atg13/Atg125 larvae is rescued by expression of Atg1Scer\UAS.cTa under the control of Scer\GAL4elav-C155.

      (Toda et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      Atg1Scer\UAS.cTa
      Atg1Scer\UAS.cWa
      Atg1UAS.cTa
      unc-513-rescue
      (Wairkar et al., 2009)
      unc-51WT
      (Mochizuki et al., 2011)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Toda
      Saccharomyces cerevisiae UAS construct of Wairkar
      Secondary FlyBase IDs
      • FBal0221026
      • FBal0220539
      References (6)