FB2024_03 , released June 25, 2024
Allele: Dmel\POSHp92
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General Information
Symbol
Dmel\POSHp92
Species
D. melanogaster
Name
FlyBase ID
FBal0284329
Feature type
allele
Associated gene
Dmel\POSH
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Zhang et al., 2010)
Mutagen
P-element activity
(Zhang et al., 2010)
Progenitor genotype
P{EP}POSHEP1206
(Zhang et al., 2010)
Cytology
Description

Imprecise excision of P{EP}POSHEP1206.

(Zhang et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:17,568,803..17,569,227 [+]
Comment:

A 425 bp deletion resulting from the imprecise excision of P{EP}POSHEP1206, removes the ATG and N-terminal coding sequences of POSH. The flanking sequences to the deletion are : 5′-GCCACGAG-3′ & 3′-TTCATCAT-5′.

(Zhang et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 5% of the homozygous POSHp92 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure.

      Approximately 6% of POSHk15815/POSHp92 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure.

      Approximately 10% of POSHp92/Df(2R)BSC45 embryos show a dorsal hole in the epidermis indicating the disruption of dorsal closure.

      Approximately 9% of the homozygous POSHp92 embryos display head involution defects.

      Approximately 16% of the homozygous POSHp92 embryos display germ-band retraction defects.

      Approximately 70% of the homozygous POSHp92 embryos fail to hatch.

      Approximately 9% of the POSHk15815/POSHp92 embryos display head involution defects.

      Approximately 10% of the POSHk15815/POSHp92 embryos display germ-band retraction defects.

      Only 12.5% of the POSHk15815/POSHp92 embryos hatch to the first instar larval stage.

      Approximately 4% of the POSHp92/Df(2R)BSC45 embryos display head involution defects.

      Approximately 7% of the POSHp92/Df(2R)BSC45 embryos display germ-band retraction defects.

      62% of the POSHp92/Df(2R)BSC45 embryos hatch to the first instar larval stage.

      (Zhang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      POSHk15815

      (Zhang et al., 2010)
      Not rescued by

      POSHp92 is not rescued by Scer\GAL4unspecified/POSHUAS.cSa

      (Zhang et al., 2010)
      Comments

      Over-expression of POSHScer\UAS.cSa under the control of Scer\GAL4pnr-MD237 fails to rescue the lethality and morphological defects in POSHk15815 and POSHp92 mutants.

      (Zhang et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      POSHp92
      posh p92
      (Zhang et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)