FlyBase Allele Report: Dmel\cv-2[KO1]

General Information

Symbol

Dmel\cv-2^KO1

Species

D. melanogaster

Name

FlyBase ID

FBal0283093

Feature type

allele

Associated gene

Dmel\cv-2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-in gene targeting

(Serpe et al., 2008)

FLPase

(Serpe et al., 2008)

I-SceI

(Serpe et al., 2008)

I-CreI

(Serpe et al., 2008)

Progenitor genotype

cv-2^F1-42

(Serpe et al., 2008)

Cytology

Description

A stop codon has been introduced at residue P142 in the CR3 domain of cv-2 exon four.

(Serpe et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die | cold sensitive

(Serpe et al., 2008)

viable

(Serpe et al., 2008)

visible | adult stage

(Serpe et al., 2008)

Phenotype Manifest In

anterior crossvein

(Serpe et al., 2008)

posterior crossvein

(Serpe et al., 2008)

wing

(Serpe et al., 2008)

wing vein

(Serpe et al., 2008)

Detailed Description

Statement

Reference

cv-2^KO1 mutant flies are homozygous viable but significant lethality is seen at 18[o]C. Adult wings lack the posterior cross vein and sometimes the anterior cross vein and the tips of some longitudinal veins.

(Serpe et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

cv-2^KO1 is rescued by Scer\GAL4^A9/cv-2^UAS.cSa

(Serpe et al., 2008)

Not rescued by

cv-2^KO1 is not rescued by Scer\GAL4^A9/cv-2^N.UAS

(Serpe et al., 2008)

Comments

Expression of one copy of cv-2^Scer\UAS.cSa under the control of Scer\GAL4^A9 rescues the posterior crossvein defects seen in homozygous cv-2^KO1 mutants.

Expression of cv-2^Un.Scer\UAS under the control of Scer\GAL4^A9 rescues the posterior crossvein defects seen in homozygous cv-2^KO1 mutants.

Expression of one copy of cv-2^N.Scer\UAS under the control of Scer\GAL4^A9 fails to rescue the posterior crossvein defects seen in homozygous cv-2^KO1 mutants.

(Serpe et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cv-2^KO1

(Matsuda and Shimmi, 2012)

cv2^KO1

(Matsuda et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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