FB2024_03 , released June 25, 2024
Allele: Dmel\Bxhdp58-1
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General Information
Symbol
Dmel\Bxhdp58-1
Species
D. melanogaster
Name
FlyBase ID
FBal0282711
Feature type
allele
Associated gene
Dmel\Bx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zenvirt et al., 2008)
Mutagen
Delta2-3 transposase
(Zenvirt et al., 2008)
Progenitor genotype
P{GawB}BxMS1096
(Zenvirt et al., 2008)
Cytology
Description

Excision of P{GawB}BxMS1096 has resulted in a deletion that extends into exon 2 of Bx, removing 128bp from the 5'UTR. Part of the P{GawB} element is retained.

(Zenvirt et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies homozygous or hemizygous for Bxhdp58-1 have held-up wings, with occasional defects in the cross-veins. The wings are small compared to wild type. Between 10 and 20% of flies are missing one or two bristles from the anterior pair of the four thoracic dorsocentral bristles. This is increased to >85% in Bxhdp58-1/Df(1)N19 females. Flies also show locomotor defects, having difficulty in standing and walking.

      One copy of Bxhdp58-1 partially rescues the wing scalloping phenotype seen in Bx5-1/+ flies.

      One copy of Bxhdp58-1 partially rescues the wing scalloping phenotype seen in Bx2/+ flies.

      (Zenvirt et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Bxhdp58-1 has visible | adult stage phenotype, enhanceable by pnr[+]/pnrVX6

      (Zenvirt et al., 2008)

      Bxhdp58-1 has visible | adult stage phenotype, enhanceable by pnrMD237/pnr[+]

      (Zenvirt et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      Bxhdp58-1 is a non-suppressor of visible | adult stage phenotype of ChiE

      (Zenvirt et al., 2008)
      Other
      Statement
      Reference

      Bxhdp58-1/Bx[+], ac1 has visible | adult stage phenotype

      (Zenvirt et al., 2008)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Bxhdp58-1 has anterior dorsocentral bristle phenotype, enhanceable by pnr[+]/pnrVX6

      (Zenvirt et al., 2008)

      Bxhdp58-1 has anterior dorsocentral bristle phenotype, enhanceable by pnrMD237/pnr[+]

      (Zenvirt et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      Bxhdp58-1 is a non-suppressor of anterior dorsocentral bristle phenotype of ChiE

      (Zenvirt et al., 2008)
      Other
      Statement
      Reference

      Bxhdp58-1/Bx[+], ac1 has anterior dorsocentral bristle phenotype

      (Zenvirt et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of pnrVX6 enhances the dorsocentral bristle loss seen in hemizygous Bxhdp58-1 mutant males. 90% of flies lack the anterior pair of bristles.

      One copy of pnrMD237 enhances the dorsocentral bristle loss seen in hemizygous Bxhdp58-1 mutant males. 90% of flies lack the anterior pair of bristles.

      Flies carrying one copy of ac1 and one copy of Bxhdp58-1 lack the anterior dorsocentral bristles. No phenotypes are observed in either heterozygote alone.

      Flies carrying one copy of Chie5.5 and one copy of Bxhdp58-1 have a wild type number of dorsocentral bristles.

      Bxhdp58-1 does not suppress the anterior dorsocentral bristle loss seen in ChiE/+ mutant flies.

      (Zenvirt et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bxhdp58-1
      dlmohdp58-1
      (Zenvirt et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)