FlyBase Allele Report: Dmel\Sulf1[Δ1]

General Information

Symbol

Dmel\Sulf1^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0280244

Feature type

allele

Associated gene

Dmel\Sulf1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(You et al., 2011)

Progenitor genotype

Sulf1^GT-000656

(You et al., 2011)

Cytology

Description

Imprecise excision of P{GT1}Sulf1^GT-000656 results in a 267bp deletion starting from position 480bp in the first exon and continuing into the first intron of Sulf1, causing a frame shift.

(You et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:16,314,222..16,314,489 [-]

Comment:

276 bp deletion resulting from the imprecise excision of P{GT1}Sulf1^GT-000656, which is reported as starting from position 480bp in the first exon and continuing into the first intron of Sulf1, causing a frame shift. Infered deletion position was mapped from the insertion site.

(You et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(You et al., 2011)

viable

(You et al., 2011)

Phenotype Manifest In

eye

(You et al., 2011)

mechanosensory chaeta | increased number

(You et al., 2011)

taste bristle | increased number

(You et al., 2011)

wing margin

(You et al., 2011)

Detailed Description

Statement

Reference

Sulf1^Δ1 adult flies exhibit a rough eye phenotype and an increased number of chemosensory bristles and ectopic mechanosensory bristles on the wing margin.

(You et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Notum^I6, Sulf1^Δ1 has partially lethal - majority die phenotype

(You et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Sulf1^Δ1 has mechanosensory chaeta | increased number phenotype, enhanceable by Notum^I6

(You et al., 2011)

Suppressed by

Statement

Reference

Sulf1^Δ1 has taste bristle | increased number phenotype, suppressible by dally⁸⁰

(You et al., 2011)

Sulf1^Δ1 has mechanosensory chaeta | increased number phenotype, suppressible by dally⁸⁰

(You et al., 2011)

NOT suppressed by

Statement

Reference

Sulf1^Δ1 has taste bristle | increased number phenotype, non-suppressible by dlp^MH20

(You et al., 2011)

Sulf1^Δ1 has mechanosensory chaeta | increased number phenotype, non-suppressible by dlp^MH20

(You et al., 2011)

Enhancer of

Statement

Reference

Sulf1^Δ1 is an enhancer of mechanosensory chaeta | increased number phenotype of dlp^MH20

(You et al., 2011)

NOT Enhancer of

Statement

Reference

Sulf1^Δ1 is a non-enhancer of mechanosensory chaeta phenotype of dally⁸⁰

(You et al., 2011)

Sulf1^Δ1 is a non-enhancer of taste bristle phenotype of dally⁸⁰

(You et al., 2011)

NOT Suppressor of

Statement

Reference

Sulf1^Δ1 is a non-suppressor of mechanosensory chaeta phenotype of dally⁸⁰

(You et al., 2011)

Sulf1^Δ1 is a non-suppressor of taste bristle phenotype of dally⁸⁰

(You et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Notum^I6 Sulf1^Δ1 double mutants exhibit 90% lethality. The surviving 10% display an increase in chemosensory bristles and ectopic mechanosensory bristles on the wing margin, compared to Notum^I6 single mutants.

dally⁸⁰ Sulf1^Δ1 double mutants exhibit a phenotype similar to dally⁸⁰ single mutants (a reduced number of bristles on the wing margin), implying dally may act downstream of Sulf1.

In dlp^MH20 Sulf1^Δ1 double mutants the number of ectopic mechanosensory bristles is increased.

(You et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sulf1^Δ1

sulf1^Δ1

(You et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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