FlyBase Allele Report: Dmel\Sarm[4621]

General Information

Symbol

Dmel\Sarm⁴⁶²¹

Species

D. melanogaster

Name

FlyBase ID

FBal0277679

Feature type

allele

Associated gene

Dmel\Sarm

Associated Insertion(s)

Carried in Construct

Also Known As

dsarm⁴⁶²¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: W949term.

(Osterloh et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,104,337..8,104,337 [+]

Nucleotide change:

G8104337A

Amino acid change:

Reported amino acid change:

W949term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Osterloh et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | embryonic stage (with Sarm⁴⁷⁰⁵)

(Foldi et al., 2017)

lethal (with Sarm⁸⁹⁶)

(Osterloh et al., 2012)

Phenotype Manifest In

embryonic/larval central nervous system | embryonic stage (with Sarm⁴⁷⁰⁵)

(Foldi et al., 2017)

neuron | embryonic stage | increased number (with Sarm⁴⁷⁰⁵)

(Foldi et al., 2017)

Detailed Description

Statement

Reference

Ect4⁴⁷⁰⁵/Ect4⁴⁶²¹ mutant embryos have more eve-positive neurons in the central nervous system compared to wild-type controls.

(Foldi et al., 2017)

The axons of homozygous olfactory receptor neurons remain intact 1 week after axon severing (in contrast to wild type).

dMP2 neurons are generated normally and the appropriate subset undergo apoptosis in homozygous animals.

(Osterloh et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of abnormal neuroanatomy | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of decreased size | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

NOT Suppressor of

Statement

Reference

Sarm⁴⁶²¹ is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Nmnat^Δ4790-1

(Neukomm et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of dendrite | larval stage phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

Sarm⁴⁶²¹/Sarm⁴⁷⁰⁵ is a suppressor of larval dorsal multidendritic neuron ddaC phenotype of Nmnat^U6:3.gRNA, Spyo\Cas9^ppk.PP

(Ji et al., 2022)

NOT Suppressor of

Statement

Reference

Sarm⁴⁶²¹ is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Nmnat^Δ4790-1

(Neukomm et al., 2017)

Sarm⁴⁶²¹ is a non-suppressor of axon | somatic clone | adult stage phenotype of Nmnat^Δ4790-1

(Neukomm et al., 2017)

Sarm⁴⁶²¹ is a non-suppressor of neuronal cell body | somatic clone | adult stage phenotype of Nmnat^Δ4790-1

(Neukomm et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The axon and cell body degeneration in Nmnat^Δ4790-1 sensory neuron clones in the adult wing cannot be rescued by combination with Ect4⁴⁶²¹.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sarm⁴⁶²¹/Sarm⁸⁹⁶ is rescued by Sarm^+tOa

(Osterloh et al., 2012)

Comments

Ect4^+tOa rescues the lethality and reverts the suppression of axonal degeneration after axon severing which is seen in Ect4⁸⁹⁶/Ect4⁴⁶²¹ animals.

(Osterloh et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Ect4⁴⁶²¹

Sarm⁴⁶²¹

(Ji et al., 2022)

dsarm⁴⁶²¹

(Foldi et al., 2017, Neukomm et al., 2017)

l(3)4621

(Osterloh et al., 2012)

sarm⁴⁶²¹

(Brace et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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