FB2024_03 , released June 25, 2024
Allele: Dmel\DCTN1-p150UAS.cLa
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General Information
Symbol
Dmel\DCTN1-p150UAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lloyd
FlyBase ID
FBal0277613
Feature type
allele
Associated gene
Dmel\DCTN1-p150
Associated Insertion(s)
Carried in Construct
P{UAS-DCTN1-p150.WT}
Key Links
Transgenic product class
wild_type
(Lloyd et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Lloyd et al., 2012)
Mutagen
in vitro construct
(Lloyd et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-DCTN1-p150.WT}
Cytology
Description

UAS regulatory sequences drive expression of wild-type DCTN1-p150.

(Lloyd et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
DCTN1-p150
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of GlScer\UAS.cLa under the control of Scer\GAL4elav-C155 results in either a moderate to severe rough eye phenotype, or pupal lethality, depending on the GlScer\UAS.cLa line used.

      Expression of GlScer\UAS.cLa under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

      (Lloyd et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      DCTN1-p150UAS.cLa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Khc[+]/Khc8

      (Lloyd et al., 2012)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      DCTN1-p150UAS.cLa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Khc[+]/Khc8

      (Lloyd et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Khc8/+ strongly suppresses the rough eye phenotype caused by expression of GlScer\UAS.cLa under the control of Scer\GAL4GMR.PF.

      (Lloyd et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      DCTN1-p150UAS.cLa/Scer\GAL4VGlut-OK371 rescues DCTN1-p150G38S

      (Lloyd et al., 2012)
      Partially rescues

      DCTN1-p150UAS.cLa/Scer\GAL4T80 partially rescues DCTN1-p150Δ22/DCTN1-p150l1

      (Lloyd et al., 2012)

      DCTN1-p150UAS.cLa/Scer\GAL4T80 partially rescues DCTN1-p150G38S/DCTN1-p150l1

      (Lloyd et al., 2012)
      Comments

      Expression of GlScer\UAS.cLa under the control of Scer\GAL4T80 rescues the lethality of Gll1/GlΔ22 and Gll1/GlG38S animals, although the rescued animals are sterile.

      Expression of GlScer\UAS.cLa under the control of Scer\GAL4VGlut-OK371 rescues the electrophysiological defects seen at the neuromuscular junction in GlG38S larvae.

      (Lloyd et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      DCTN1-p150Scer\UAS.cLa
      DCTN1-p150UAS.cLa
      GlScer\UAS.cLa
      p150WT
      (Lloyd et al., 2012)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lloyd
      Secondary FlyBase IDs
        References (1)