FB2024_03 , released June 25, 2024
Allele: Dmel\l(2)gl3644
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General Information
Symbol
Dmel\l(2)gl3644
Species
D. melanogaster
Name
FlyBase ID
FBal0276711
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Haenfler et al., 2012)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 24 hours after clone induction, type I and II neuroblast clones in l(2)gl334/l(2)gl3644 larval brains contain a single neuroblast, as occurs in wild type. However, at 48 hours after clone induction, the mutant type I and II neuroblast clones contain supernumerary neuroblasts.

      Intermediate neural progenitor cell derived clones in l(2)gl334/l(2)gl3644 larval brains contain multiple supernumerary type II neuroblasts.

      l(2)gl334/l(2)gl3644 larval brains contain an increased number of type II neuroblasts and intermediate neural progenitor cells compared to wild type.

      (Haenfler et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      aPKCk06403/+ suppresses the increased number of type II neuroblasts and intermediate neural progenitor cells seen in l(2)gl334/l(2)gl3644 larval brains.

      The formation of supernumerary type I neuroblasts which is seen in l(2)gl334/l(2)gl3644 larval brains is suppressed by expression of either numbScer\UAS.T:Ivir\HA1, numbΔN.Scer\UAS.hs.T:Hsap\MYC, numbS2A.Scer\UAS.T:Ivir\HA1, numbS2D.Scer\UAS.T:Ivir\HA1 or numbΔC.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ase.neuro, but is not suppressed by expression of either numbΔPTB.Scer\UAS.T:Ivir\HA1 or numbΔAB.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ase.neuro.

      The formation of supernumerary type I neuroblasts which is seen in l(2)gl334/l(2)gl3644 larval brains is suppressed by co-expression of numbΔC.Scer\UAS.T:Ivir\HA1, but is not suppressed by co-expression of either numbΔAB.Scer\UAS.T:Ivir\HA1 or numbΔPTB.Scer\UAS.T:Ivir\HA1.

      (Haenfler et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)gl3644
      lgl3644
      (Haenfler et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)