FB2024_03 , released June 25, 2024
Allele: Dmel\numbΔN.UAS.Tag:MYC
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General Information
Symbol
Dmel\numbΔN.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0083780
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
P{UAS-numb.ΔN.Myc}
Key Links
Transgenic product class
inframe_deletion
(Knoblich et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Knoblich et al., 1997)
Mutagen
in vitro construct
(Knoblich et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-numb.ΔN.Myc}
Cytology
Description

UASt regulatory sequences drive expression of a numb lacking the N-terminal 41 amino acid residues. The protein is tagged with the Tag:MYC epitope.

(Knoblich et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
numb
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4sca-109-68-mediated expression in SOP cells causes duplicated microchaete bristles without sockets, caused by a cell fate transformation between the daughter cells of the IIA cell.

      (Knoblich et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The formation of supernumerary type I neuroblasts which is seen in l(2)gl334/l(2)gl3644 larval brains is suppressed by expression of numbΔN.Scer\UAS.hs.T:Hsap\MYC under the control of Scer\GAL4ase.neuro.

      (Haenfler et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid, transfected into Schneider S2 cells, and used to study the domains of numb protein required to inhibit Dl-dependent.

      (Knoblich et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      numbΔN.Scer\UAS.hs.T:Hsap\MYC
      numbΔN.UAS.Tag:MYC
      numbΔN.UAS.hs.T:Myc
      Name Synonyms
      Secondary FlyBase IDs
        References (2)