FlyBase Allele Report: Dmel\Tollo[59]

General Information

Symbol

Dmel\Tollo⁵⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0267038

Feature type

allele

Associated gene

Dmel\Tollo

Associated Insertion(s)

Carried in Construct

Also Known As

Toll-8⁵⁹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Yagi et al., 2010)

Progenitor genotype

Tollo^EY01776

(Yagi et al., 2010)

Cytology

Description

Imprecise excision of P{EPgy2}Tollo^EY01776 generates a deletion that uncovers the Tollo coding region plus at least 5kb of upstream and downstream region but the nearby ORFs CG6888 and Best4 are intact.

(Yagi et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Yagi et al., 2010)

partially lethal - majority live (with Df(3L)Brd15)

(Yagi et al., 2010)

viable

(Yagi et al., 2010)

Phenotype Manifest In

femur

(Yagi et al., 2010)

femur (with Df(3L)Brd6)

(Yagi et al., 2010)

femur (with Df(3L)ED218)

(Yagi et al., 2010)

femur (with Tollo⁵⁸)

(Yagi et al., 2010)

leg

(Yagi et al., 2010)

leg (with Df(3L)Brd6)

(Yagi et al., 2010)

leg (with Df(3L)ED218)

(Yagi et al., 2010)

leg (with Tollo⁵⁸)

(Yagi et al., 2010)

tarsal segment

(Yagi et al., 2010)

tarsal segment (with Df(3L)Brd6)

(Yagi et al., 2010)

tarsal segment (with Df(3L)ED218)

(Yagi et al., 2010)

tarsal segment (with Tollo⁵⁸)

(Yagi et al., 2010)

tibia

(Yagi et al., 2010)

tibia (with Df(3L)Brd6)

(Yagi et al., 2010)

tibia (with Df(3L)ED218)

(Yagi et al., 2010)

tibia (with Tollo⁵⁸)

(Yagi et al., 2010)

Detailed Description

Statement

Reference

Tollo⁵⁹ mutant embryos do not display defects in cell intercalation.

(Paré et al., 2014)

Septic injury of Tollo⁵⁹ mutant flies results in activation of the innate immune response.

Tollo⁵⁹ mutant flies exhibit a slight defect in adult leg formation. They have a normal number of segments but the legs are bent between the tibia and tarsus and thus twisted towards other directions. Flies with a stronger phenotype exhibit malformed femurs and double bending in both tibia and tarsus. The penetrance of this leg phenotype is approximately 20% in Tollo⁵⁸/Tollo⁵⁹ mutants, 13% in Tollo⁵⁹/Df(3L)Brd6 mutants and 44% in Tollo⁵⁹/Df(3L)ED218 mutants.

(Yagi et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

18w^Δ76, Toll-6^5A, Tollo⁵⁹ has abnormal cell adhesion phenotype

(Paré et al., 2014)

18w^Δ76, Toll-6^5A, Tollo⁵⁹ has abnormal planar polarity phenotype

(Paré et al., 2014)

Toll-6^5A, Tollo⁵⁹ has abnormal cell adhesion phenotype

(Paré et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Toll-6^5A, Tollo⁵⁹ has embryo | maternal effect phenotype, suppressible by 18w^KI.WT

(Tamada et al., 2021)

NOT suppressed by

Statement

Reference

Toll-6^5A, Tollo⁵⁹ has embryo | maternal effect phenotype, non-suppressible by 18w^C2YF

(Tamada et al., 2021)

Other

Statement

Reference

18w^attP, Toll-6^5A, Tollo⁵⁹ has embryo | maternal effect phenotype

(Tamada et al., 2021)

18w^Δ76, Toll-6[+]/Toll-6^5A, Tollo[+]/Tollo⁵⁹ has embryo phenotype

(Paré et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

18w^Δ76/+; Tollo⁵⁹/+; Toll-6^5A/+ triple mutants display a significant reduction in axis elongation.

(Paré et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Toll-8⁵⁹

(Tamada et al., 2021, Paré et al., 2019)

Tollo⁵⁹

(Villedieu et al., 2023, Yagi et al., 2010)

Name Synonyms

Toll-859

(Paré et al., 2014)

Secondary FlyBase IDs

References (5)

Report Sections

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