A 3,479 bp deletion resulting from Scer\FLP1-mediated recombination between Scer\FLP1 recognition target (Scer\FRT) sites in PBac{RB}CG10158e02576 and PBac{RB}ihoge02142 that completely removes the ihog coding sequence and part of the 5' untranslated region of the adjacent gene CG10158.
boiC1, ihogDC1 has abnormal cell shape | embryonic stage phenotype
boiC1, ihogDC1 has embryonic/larval muscle cell | embryonic stage phenotype
boiC1, ihogDC1 has photoreceptor neuron phenotype
boiC1, ihogDC1 has wing disc | third instar larval stage phenotype
Larvae that are double mutant for ihogDC1 and boiC1 die 24 to 48 hours after hatching and never reach third instar (L3).
The viability of boiC1; ihogDC1 double mutants is rescued by the basal level of expression of ihogScer\UAS.T:Hsap\MYC in the absence of any Scer\GAL4 driver.
In boiC1 hemizygotes, eye development is severely compromised in the presence of mitotic clones of cells mutant for ihogDC1/ihogDC1 leading to structural defects. Photoreceptor cell differentiation is impaired in the mutant cells.
The eye morphology in ihogDC1 mosaics in boiC1 hemizygotes is rescued by the basal level of expression of ihogScer\UAS.T:Hsap\MYC in the absence of any Scer\GAL4 driver.
In contrast to control clones, double mutant clones (homozygous ihogDC1 clones in boiC1 hemizygotes) in third instar wing imaginal discs often straddle the anterior-posterior boundary and form tight borders with both anterior and posterior cells. This modified segregation behaviour indicates that anterior cells lacking both ihog and boi sort out from the anterior compartment into posterior territory. However, similarly to wild-type cells, double mutant posterior clones of homozygous ihogDC1 mutant cells in boiC1 hemizygotes do respect the compartment boundary and do not sort into anterior territory.
ihogDC1 is rescued by ihogUAS.Tag:MYC
