FB2024_03 , released June 25, 2024
Allele: Dmel\Uba1H42
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General Information
Symbol
Dmel\Uba1H42
Species
D. melanogaster
Name
FlyBase ID
FBal0265022
Feature type
allele
Associated gene
Dmel\Uba1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lee et al., 2008)
Progenitor genotype
Cytology
Description

Mutation producing in a new splicing donor site. This results in inappropriate splicing and causes an in-frame internal deletion of amino acid residues 162-255.

(Lee et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:9,691,698..9,692,557 [-]
Comment:

Reported as an in frame deletion from amino acid residue 162 to 255 of Uba1.

(Lee et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones survive well and are recovered in the adult eye at both 25 and 29[o]C.

      (Lee et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Uba1H42/Uba1H42 is a suppressor of visible phenotype of hidGMR.PG

      (Lee et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Uba1H42 is a suppressor of eye phenotype of hidGMR.PG

      (Christiansen et al., 2013)

      Uba1H42/Uba1H42 is a suppressor of eye phenotype of hidGMR.PG

      (Lee et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Eyes mosaic for Uba1H42 (generated using the ey-FLP/FRT system) suppress the WGMR.PG eye phenotype. This suppression is cell autonomous.

      (Christiansen et al., 2013)

      The small eye phenotype caused by WGMR.PG is moderately strongly suppressed by inducing homozygous Uba1H42 clones in the eye. The rescued eye tissue is homozygous for Uba1H42, indicating that the suppression is cell autonomous.

      (Lee et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Uba1H42
      (Christiansen et al., 2013, Lee et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)