FB2024_03 , released June 25, 2024
Allele: Dmel\Sec6Ex15
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General Information
Symbol
Dmel\Sec6Ex15
Species
D. melanogaster
Name
FlyBase ID
FBal0264707
Feature type
allele
Associated gene
Dmel\Sec6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Murthy et al., 2005)
Mutagen
Delta2-3 transposase
(Murthy et al., 2005)
Progenitor genotype
P{EP}CthEP2021
(Murthy et al., 2005)
Caused by aberration
Df(2R)Sec6Ex15
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a deletion that extends from the codon encoding amino acid residue 397 of sec6 through the end of the transcription unit and continues to the 21st base pair of the 5' untranslated region of the neighbouring Eip55E gene.

(Murthy et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:18,626,596..18,627,927 [+]
Comment:

Deletion of part of Sec6 resulting from imprecise excsion of P{EP}Eip55EEP2021. The deletion location was estimated from the report that the Eip55EEx15 deletion extends from amino acid 397 of Sec6 to the 21st base pair of the 5' untranslated region of Eip55E. The deletion was mapped from the first base of Sec6 codon 397 to the insertion site of P{EP}Eip55EEP2021 in the 5' UTR of Eip55E.

(Murthy et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  muscular dystrophy
      modeled by DgO86
      (Yatsenko et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sec6Ex15/Sec6Ex15 class IV da neurons in larval somatic clones manifest defects in dendritic growth (thinning of terminal dendrites, reduced total dendrite length and number of terminal branches, decreased number of dendritic intersections, varicosities).

      (Peng et al., 2015)

      Homozygous, sec6Ex15/Df(2R)PC4 and sec6Ex15/Df(2R)Ex212 larvae die from growth arrest at 96 hours after egg laying (AEL). The larvae are much smaller than normal, never being larger than wild-type larvae at 24 hours AEL.

      Females containing homozygous germline clones do not lay eggs. Egg chambers form and exit the germarium in these females, but after stage 3, cell membranes are frequently absent between the germ line cells and ring canals are clumped together in the middle of a large, multinucleate cell. When individual cells can be distinguished in the mutant egg chamber, the oocyte is often mispositioned anteriorly.

      (Murthy et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sec6Ex15/RopG27 transheterozygous third instar larvae show decreased number of terminal dendritic branches in the class IV dendritic arborizing neurons compared to either Sec6Ex15/+ or RopG27/+ single heterozygotes.

      (Peng et al., 2015)

      The fraction of oocytes showing endocytic activity is reduced compared to wild type in EndoB54/Sec6Ex15 double heterozygotes.

      (Tsai et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sec6Ex15
      (Yatsenko et al., 2021, Peng et al., 2015)
      sec6Ex15
      (Woichansky et al., 2016, Tsai et al., 2014, Murthy et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)