FlyBase Allele Report: Dmel\egg[null]

General Information

Symbol

Dmel\egg^null

Species

D. melanogaster

Name

FlyBase ID

FBal0263557

Feature type

allele

Associated gene

Dmel\egg

Associated Insertion(s)

P+PBac{XP5.WH5}egg^null

Carried in Construct

Also Known As

dSETDB1^null

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Tzeng et al., 2007)

Mutagen

FLPase

(Tzeng et al., 2007)

Progenitor genotype

PBac{WH}f07054

(Tzeng et al., 2007)

P{XP}d11187

(Tzeng et al., 2007)

Associated Insertion(s)

P+PBac{XP5.WH5}egg^null

Cytology

Description

Deletion of the entire egg genomic region.

(Tzeng et al., 2007)

Allele components

Component

Use(s)

Inserted element

P+PBac{XP5.WH5}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage (with Df(2R)Dll-MP)

(Clough et al., 2014)

abnormal locomotor behavior | adult stage (with Df(2R)ED4065)

(Clough et al., 2014)

increased cell death | oogenesis (with Df(2R)Dll-MP), with Scer\GAL4^NP1624, egg^UAS.cTa

(Clough et al., 2014)

lethal | male (with Df(2R)ED4065)

(Clough et al., 2014)

partially lethal - majority die (with Df(2R)Dll-MP)

(Clough et al., 2014)

partially lethal - majority die (with Df(2R)ED4065)

(Clough et al., 2014)

partially lethal - majority die (with egg^GS7132)

(Tzeng et al., 2007)

partially lethal - majority die | recessive

(Tzeng et al., 2007)

short lived | male (with Df(2R)Dll-MP)

(Clough et al., 2014)

visible | adult stage (with Df(2R)Dll-MP)

(Clough et al., 2014)

visible | adult stage (with Df(2R)ED4065)

(Clough et al., 2014)

Phenotype Manifest In

wing

(Tzeng et al., 2007)

wing (with Df(2R)Dll-MP)

(Clough et al., 2014)

wing (with Df(2R)ED4065)

(Clough et al., 2014)

wing (with egg^GS7132)

(Tzeng et al., 2007)

Detailed Description

Statement

Reference

egg^null/Df(2R)Dll-MP transheterozygotes are semi-lethal, display a low male:female ratio, and the few males die within 2-3 days; egg^null/Df(2R)ED4065 transheterozygotes are near lethal and no adult males eclose. egg^null/Df(2R)Dll-MP and egg^null/Df(2R)ED4065 transheterozygous adults exhibit shaky, uncoordinated movements and held-out wings that are incompletely expanded, as compared to controls; the locomotor and wing phenotypes of egg^null/Df(2R)Dll-MP transheterozygotes are more pronounced in males than in females.

The ovaries of egg^null/Df(2R)Dll-MP transheterozygous females that also express egg^Scer\UAS.cTa under the control of Scer\GAL4^tj-NP1624 do not display any obvious early oogenesis defects, namely in germline stem cells differentiation, in germline cyst formation and encapsulation, in egg chamber budding from the germarium and in early oogenesis progression, but egg chambers arrest and undergo apoptosis at stage 5 of oogenesis, as compared to controls.

(Clough et al., 2014)

egg^null homozygotes and egg^null/egg^GS7132 trans-heterozygous escapers have spread-out wings.

(Tzeng et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

egg^GS7132

(Tzeng et al., 2007)

Rescued by

egg^GS7132/egg^null is rescued by egg^UAS.cTa/Scer\GAL4^arm.PS

(Tzeng et al., 2007)

Comments

Scer\GAL4^arm.PS-mediated expression of egg^Scer\UAS.cTa rescues the egg^GS7132 and egg^GS7132/egg^null phenotypes.

(Tzeng et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dSETDB1^null

(Clough et al., 2014, Tzeng et al., 2007)

egg^null

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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