FB2024_03 , released June 25, 2024
Allele: Dmel\sds22UAS.cJa
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General Information
Symbol
Dmel\sds22UAS.cJa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Jiang
FlyBase ID
FBal0263482
Feature type
allele
Associated gene
Dmel\sds22
Associated Insertion(s)
Carried in Construct
P{UAS-sds22.J}
Key Links
Transgenic product class
cDNA
(Jiang et al., 2011)
wild_type
(Jiang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Jiang et al., 2011)
wild_type
(Jiang et al., 2011)
Mutagen
in vitro construct
(Jiang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-sds22.J}
Cytology
Description

UAS regulatory sequences drive expression of a full-length sds22 cDNA.

(Jiang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sds22
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sds22Scer\UAS.cJa under the control of Scer\GAL4ey.PU does not cause external eye defects.

      (Jiang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      sds22UAS.cJa, Scer\GAL4ey.PU is a non-suppressor of visible phenotype of Ras85DV12.UAS, Scer\GAL4ey.PU

      (Jiang et al., 2011)
      Other
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      sds22UAS.cJa, Scer\GAL4ey.PU is a non-suppressor of eye phenotype of Ras85DV12.UAS, Scer\GAL4ey.PU

      (Jiang et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU in clones in the eye-antennal disc (where the clones are also homozygous for scrib673) results in strong tumour growth at 7 days AEL. These animals grow as larvae until 13 days AEL and die before pupation. Co-expression of sds22Scer\UAS.cJa in these clones strongly suppresses the tumour growth phenotype in all clones observed at 7 days AEL and most of these animals can pupate, but die as early pupae.

      The eye-antennal disc defects seen in larvae carrying homozygous scrib673 clones and the eye defects seen in adult escapers carrying homozygous scrib673 clones are suppressed by expression of sds22Scer\UAS.cJa under the control of Scer\GAL4Act.PU in the clones.

      Eye overgrowth caused by expression of Ras85DV12.Scer\UAS under the control of Scer\GAL4ey.PU is not suppressed by co-expression of sds22Scer\UAS.cJa.

      (Jiang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      sds22Scer\UAS.cJa
      sds22UAS.cJa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Jiang
      Secondary FlyBase IDs
        References (2)