FB2024_03 , released June 25, 2024
Allele: Dmel\sds22Δ2.8
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General Information
Symbol
Dmel\sds22Δ2.8
Species
D. melanogaster
Name
FlyBase ID
FBal0263480
Feature type
allele
Associated gene
Dmel\sds22
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Jiang et al., 2011)
Progenitor genotype
P{EPgy2}EY06161
(Jiang et al., 2011)
Caused by aberration
Df(3R)sds22Δ2.8
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a 2.8kb deletion that completely removes the CREG gene and removes part of sds22 (the entire coding region is deleted).

(Jiang et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye morphogenesis is disrupted and eye size is reduced in animals containing eyes that are almost completely homozygous for sds22Δ2.8. In addition, mutant photoreceptor cells, cone cells and undifferentiated cells are mislocalised in the optic stalk of these animals.

      (Jiang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      sds22Δ2.8 has eye disc | somatic clone phenotype, suppressible | somatic clone by Scer\GAL4Act.PU/zipGD1566

      (Jiang et al., 2011)
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU in clones in the eye-antennal disc (where the clones are also homozygous for sds22Δ2.8) results in extensive hyperproliferation of the clones in the eye-antennal disc at 7 days after egg laying (AEL), but in addition, clonal cells are also seen in the ventral nerve cord at low frequency. At 15 days AEL, significant numbers of clonal cells are seen spreading from a primary tumour in the brain into the ventral nerve cord. In addition, as the tumours grow, the two eye-antennal discs appear to fuse into one large mass. These animals can grow as larvae for up to 15 days AEL and die before pupation or as early pupae.

      The cell invasion phenotype (mislocalisation to the optic stalk) shown by sds22Δ2.8 eye disc cells is suppressed if the cells are also expressing zipGD1566 under the control of Scer\GAL4Act.PU.

      (Jiang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      sds22Δ2.8 is rescued by sds22UAS.cJa/Scer\GAL4ey.PU

      (Jiang et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sds22Δ2.8
      (Jiang et al., 2011)
      Δ2.8
      (Jiang et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)