FlyBase Allele Report: Dmel\Caf1-55[HMS00051]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\Caf1-55^HMS00051

General Information

Symbol

Dmel\Caf1-55^HMS00051

Species

D. melanogaster

Name

FlyBase ID

FBal0263080

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00051}

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00051}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of azoospermia

CEA

(Li et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of azoospermia

is ameliorated by Hsap\RBBP7^UAS.cLa

(Li et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | spermatogenesis, with Scer\GAL4^nanos.PU

(Li et al., 2023)

abnormal size | larval stage, with Scer\GAL4^ppl.PU

(Yao et al., 2018)

decreased size | adult stage, with Scer\GAL4^nanos.PU

(Li et al., 2023)

decreased size | adult stage, with Scer\GAL4^tj.PU

(Li et al., 2023)

decreased size | larval stage, with Scer\GAL4^nanos.PU

(Li et al., 2023)

decreased size | larval stage, with Scer\GAL4^tj.PU

(Li et al., 2023)

increased cell number | spermatogenesis, with Scer\GAL4^tj.PU

(Li et al., 2023)

increased occurrence of cell division | spermatogenesis, with Scer\GAL4^nanos.PU

(Li et al., 2023)

increased occurrence of cell division | spermatogenesis, with Scer\GAL4^tj.PU

(Li et al., 2023)

lethal - all die during embryonic stage | paternal effect, with Scer\GAL4^nanos.PU

(Li et al., 2023)

majority die during embryonic stage | paternal effect, with Scer\GAL4^tj.PU

(Li et al., 2023)

visible, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

Phenotype Manifest In

cyst cell of testis | increased number, with Scer\GAL4^nanos.PU

(Li et al., 2023)

cyst cell of testis | increased number, with Scer\GAL4^tj.PU

(Li et al., 2023)

embryonic/larval fat body | larval stage, with Scer\GAL4^ppl.PU

(Yao et al., 2018)

larval testis, with Scer\GAL4^nanos.PU

(Li et al., 2023)

larval testis, with Scer\GAL4^tj.PU

(Li et al., 2023)

lipid droplet | larval stage, with Scer\GAL4^ppl.PU

(Yao et al., 2018)

male fusome, with Scer\GAL4^tj.PU

(Li et al., 2023)

male fusome | absent, with Scer\GAL4^nanos.PU

(Li et al., 2023)

male germline cell | absent, with Scer\GAL4^nanos.PU

(Li et al., 2023)

male germline cell | increased number, with Scer\GAL4^tj.PU

(Li et al., 2023)

spermatozoon | absent, with Scer\GAL4^nanos.PU

(Li et al., 2023)

spermatozoon | decreased number, with Scer\GAL4^tj.PU

(Li et al., 2023)

testis, with Scer\GAL4^nanos.PU

(Li et al., 2023)

testis, with Scer\GAL4^tj.PU

(Li et al., 2023)

wing, with Scer\GAL4^bbg-C96

(Ellis et al., 2015)

Detailed Description

Statement

Reference

Expressing Caf1-55^HMS00051 under the control of Scer\GAL4^ppl.PU induces significantly smaller lipid droplets in the larval fat body, as compared to controls.

(Yao et al., 2018)

Expression of Caf1-55^HMS00051 under the control of Scer\GAL4^bbg-C96 results in a fraction of individuals exhibiting wing nicking.

(Ellis et al., 2015)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^tj.PU has increased mortality during development | paternal effect phenotype, suppressible by Hsap\RBBP7^UAS.cLa, Scer\GAL4^tj.PU

(Li et al., 2023)

NOT suppressed by

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^tj.PU has majority die during embryonic stage | paternal effect phenotype, non-suppressible by Hsap\RBBP7^Δ.UAS, Scer\GAL4^tj.PU

(Li et al., 2023)

Enhancer of

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^bbg-C96 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Caf1-55^HMS00051, Scer\GAL4^bbg-C96 is an enhancer of increased cell death phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Suppressor of

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^ppl.PU is a suppressor of abnormal size | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^bbg-C96 is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Caf1-55^HMS00051, Scer\GAL4^bbg-C96 is an enhancer of wing disc phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Suppressor of

Statement

Reference

Caf1-55^HMS00051, Scer\GAL4^ppl.PU is a suppressor of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Caf1-55^HMS00051, Scer\GAL4^ppl.PU is a suppressor | partially of lipid droplet | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Caf1-55^HMS00051 enhances the wing nicking phenotype, and enhances the wing disc increased cell death along the dorsal-ventral wing margin of flies expressing dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96.

(Ellis et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Caf1-55^HMS00051 is rescued by Caf1-55^UAS.cHa/Scer\GAL4^tj.PU

(Li et al., 2023)

Not rescued by

Caf1-55^HMS00051 is not rescued by Scer\GAL4^tj.PU/Caf1-55^Δ.UAS

(Li et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

34069

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00051}attP2

HMS00051

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00051}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Caf1-55^HMS00051

Caf1^HMS00051

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections