FlyBase Allele Report: Dmel\Nurf-38[GL00369]

General Information

Symbol

Dmel\Nurf-38^GL00369

Species

D. melanogaster

Name

FlyBase ID

FBal0262835

Feature type

allele

Associated gene

Dmel\Nurf-38

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00369}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00369}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00369

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

some die during pupal stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

Phenotype Manifest In

embryonic/larval dorsal tracheal branch | larval stage, with Scer\GAL4^btl.PS

(Hudson et al., 2023)

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

posterior wing margin, with Scer\GAL4^en.PU

(Dietz et al., 2015)

terminal tracheal cell | larval stage, with Scer\GAL4^btl.PS

(Hudson et al., 2023)

wing blade, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing vein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expressing Nurf-38^GL00369 under the control of Scer\GAL4^ppl.PU does not significantly affect lipid droplet size in the larval fat body, as compared to controls.

(Yao et al., 2018)

Expression of Nurf-38^GL00369 results in: ectopic veins, disrupted posterior wing edge and blisters (with Scer\GAL4^en.PU, no phenotype at 18[o]C), increased pupal lethality or strong eye phenotype (with Scer\GAL4^ey.PH). Expression driven by Scer\GAL4^Act5C.PI is lethal; no overt adult phenotype is observed with either Scer\GAL4^GMR.PF or Scer\GAL4^nub.PK.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Nurf-38^GL00369, Scer\GAL4^ppl.PU is a non-suppressor of abnormal size | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Other

Statement

Reference

Nurf-38^GL00369, Scer\GAL4^fkh.PH, p53^{UAS.A.Tag:MYC} has increased cell death phenotype

(Zhang et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nurf-38^GL00369, Scer\GAL4^drm.7.1 is an enhancer of terminal tracheal cell | larval stage phenotype of Scer\GAL4^drm.7.1, trc^GL01127

(Hudson et al., 2023)

NOT Suppressor of

Statement

Reference

Nurf-38^GL00369, Scer\GAL4^ppl.PU is a non-suppressor of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Nurf-38^GL00369, Scer\GAL4^ppl.PU is a non-suppressor of lipid droplet | larval stage phenotype of Scer\GAL4^ppl.PU, mrt^F931

(Yao et al., 2018)

Other

Statement

Reference

Nurf-38^GL00369, Scer\GAL4^drm.7.1, trc^GL01127 has embryonic/larval dorsal tracheal branch | larval stage phenotype

(Hudson et al., 2023)

Nurf-38^GL00369, Scer\GAL4^fkh.PH, p53^{UAS.A.Tag:MYC} has salivary gland phenotype

(Zhang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Nurf-38^GL00369 and p53^{Scer\UAS.A.T:Hsap\MYC} under the control of Scer\GAL4^fkh.PH results in small salivary glands and high levels of apoptotic cell death.

(Zhang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35444